Timing of Anastrozole/Arimidex? Does it have a half life?

[totalburnout]

Question that popped into my head the other day after reading a thread on here...

Does anastrozole have a half life?
When do you take anastrozole?

After researching anastrozole initially I came to the conclusion that the drug works by preventing aromatization. Now I understand that's basic knowledge but when applied, that would seem to mean that once you've already converted T to E2, anastrozole will not help you regulate/control your estrogen.

It would appear the drug would not be effective catching the upswing in T before any conversion can be made. So how do you time the anastrozole? Peak for T would be 2-3days post injection. So are you taking anastrozole with the injection and then 2 days later. Are you taking anastrozole only 2 days later?


Once that's covered, when do you take anastrozole in relation to hCG injections? I take the anastrozole with both of my weekly hCG doses (two consecutive days of 300iu hCG injections prior to T injection).

Is this the right line of thinking?
How are you handling the anastrozole with your injections.

*i understand that other Aromatase inhibitor (AI) drugs may work differently and not just prevent aromatization but also reduce estrogen as well?

 

[Mprtz]

FWIW my protocol calls for .5 mg anastrozole 24 hours after T injection. Human Chorionic Gonadotropin (HCG) comes another 24 hours after that.

 

[Megatron28]

The half life is 46.8 hours.

 

[totalburnout]

And what's your protocol for T? I would assume you're injecting every 3 days, which would mean the Aromatase inhibitor (AI) would be catching the T on the upswing. The hCG is probably timed a day before your next shot and is also being handled by the previous days Aromatase inhibitor (AI). Is that an accurate guess?

 

[totalburnout]

The half life is 46.8 hours.

/Can't tell if serious face.

Answer sounds very precise. Can't tell if its sarcasm or truly has been studied that precisely.

 

[Megatron28]

/Can't tell if serious face.

Answer sounds very precise. Can't tell if its sarcasm or truly has been studied that precisely.

That's what the Google says it is.

 

[totalburnout]

That's what the Google says it is.

Doh! I was on that wiki too, didn't see it on the right side.

Now two questions;
Has it been your experience that its still effective for you 2 days later?

Does anastrozole also breakdown estrogen that has already been converted? I.e., anastrozole inhibits conversion, but say you have X amount of estrogen already in your body - will it "break down" that estrogen? I.e., if you have super low E2 and then take anastrozole but no T or hCG, will that continue to lower your E2? or inversely, if you have super high E2 and then take anastrozole but no T or hCG, will that continue to lower your E2?

All my searches lead me to breast cancer info or posts on here by possibly uneducated users in the steroid forum.

 

[Mprtz]

And what's your protocol for T? I would assume you're injecting every 3 days, which would mean the Aromatase inhibitor (AI) would be catching the T on the upswing. The hCG is probably timed a day before your next shot and is also being handled by the previous days Aromatase inhibitor (AI). Is that an accurate guess?

T every 3.5 days, so hCG is 1.5 days before next shot. Before I switched to this the 7-day protocol was Aromatase inhibitor (AI) one day after T, hCG 2 and 4 days before T.

 

[1693]

I think aromasin is better. From what I read it won't crash the E2 down to nothing and make a guy suffer. Think it's suppose to knock it down like 85%, which is a good thing because a guy often takes too much of an Aromatase inhibitor (AI) because they are scared of growing moobs.

Aromasin is better for the lipid panel too than arimidex.

Sometimes .5mg per week of arimidex is too much.

Some guys don't feel good on any dose of arimidex.

 

[totalburnout]

I've read the opposite about Nolvadex/aromasin crashing E2 greater than Anastrozole/Arimidex since aromasin actually binds at the receptors where E2 would bind.

I have read that the anastrozole will more drastically effect cholesterol and I believe that to be my experience as well. My cholesterol was borderline high and I've always eaten an extremely healthy diet. Unfortunately I had no baseline cholesterol numbers to compare the post TRT/AI numbers against. I would hypothesize that pre Aromatase inhibitor (AI), my cholesterol was probably great. It's still within healthy limits at this point.

 

[1693]

I've read the opposite about Nolvadex/aromasin crashing E2 greater than Anastrozole/Arimidex since aromasin actually binds at the receptors where E2 would bind.

I have read that the anastrozole will more drastically effect cholesterol and I believe that to be my experience as well. My cholesterol was borderline high and I've always eaten an extremely healthy diet. Unfortunately I had no baseline cholesterol numbers to compare the post TRT/AI numbers against. I would hypothesize that pre Aromatase inhibitor (AI), my cholesterol was probably great. It's still within healthy limits at this point.

Is this what you meant to write because nolvadex and aromasin are not the same.

I was just reading a new thread on another forum about guys crushing their E2 using .5mg per week.

 

[Megatron28]

Doh! I was on that wiki too, didn't see it on the right side.

Now two questions;
Has it been your experience that its still effective for you 2 days later?

Does anastrozole also breakdown estrogen that has already been converted? I.e., anastrozole inhibits conversion, but say you have X amount of estrogen already in your body - will it "break down" that estrogen? I.e., if you have super low E2 and then take anastrozole but no T or hCG, will that continue to lower your E2? or inversely, if you have super high E2 and then take anastrozole but no T or hCG, will that continue to lower your E2?

All my searches lead me to breast cancer info or posts on here by possibly uneducated users in the steroid forum.

Sure it is effective two days later. Just not as effective. The half life means that after ~48 hours the drug is still in your system at half its potency. Just like testosterone with its ester. Test Cyp has a half life of ~5-7 days. There is still T is your system after 5-7 days -- just less of it unless you put in a new injection to top you off.

I am not an expert on all the AI's. My understanding though is that there are two types. One "ties up" the estrogen. The other "annihilates" it. Both methods are effective. There is some good info on AI's in the Steroid Profile section up top if I recall correctly.

Your question about what happens to E2 when you don't take anymore T or Human Chorionic Gonadotropin (HCG) seems purely academic. I can't see where that would ever happen in real life. You would either inject it or produce it on your own. Are you worried about the guy who is shut down AND not injecting T? Then yes, he would not want to keep taking an Aromatase inhibitor (AI) because it would totally crash his E2.

 

[bigben34]

I think aromasin is better. From what I read it won't crash the E2 down to nothing and make a guy suffer. Think it's suppose to knock it down like 85%, which is a good thing because a guy often takes too much of an Aromatase inhibitor (AI) because they are scared of growing moobs.

Aromasin is better for the lipid panel too than arimidex.

Sometimes .5mg per week of arimidex is too much.

Some guys don't feel good on any dose of arimidex.

I'm one of those guys that doesn't feel good on Adex at any dose....I even tried .1mg. I get hot flashes, fatigue, and loss of libido within 12 hours.
I let my E2 come back up for a couple weeks and now I've started Aromasin...So far, so good. I'm starting with 3mg ED for a couple weeks and then I'll get BW/see how i feel...

 

[totalburnout]

Is this what you meant to write because nolvadex and aromasin are not the same.

I was just reading a new thread on another forum about guys crushing their E2 using .5mg per week.

You're right, I was confusing aromasin with nolvadex. I'm not familiar with aromasin.

 

[IMT staff]

Sometimes it is best to split the dose but with lower dosages like .5 and .25mg it is better to take it the day after your shot.

 

[totalburnout]

After the T shy to get it as it peaks, correct?

When in relation to hCG? I feel that injecting 250iu's on hCG on back to back days while on my weekly protocol of T, makes the most impact on estrogen.

 

[i love lamp]

Onset of estradiol reduction: 70% reduction after 24 hours; 80% after 2 weeks therapy

Duration of estradiol reduction: 6 days

Absorption: Well absorbed; extent of absorption not affected by food

Half-life elimination: ~50 hours

Time to peak, plasma: ~2 hours without food; 5 hours with food