A side effect I noticed from adex is that regardless of E2 the adex itself causes dry skin and joint pain in my hands - or as I lovingly call it 'adex ache'. It's true that these are signs of low E2, but I get these whenever I take adex even with elevated E2. So it's true that what you are feeling may be caused by low E2, but the AI's themselves are drugs which do have side effects in some.