I have a small lump under my right nipple. I have had it for years but it was never tender until I began TRT about nine months ago. I initially used 100mg of Formestane twice daily for control. On a scale of 1-10 it reduced the tenderness down to about a two. I added Novadex to the mix to see what affect it would have. As far as I can tell it has had none. About a week ago I started using letro. The tenderness is completely gone and my 5 years old gyno is getting smaller.