Experience with long esters? (Nebido)

[Vigilante]

Wassup guys,

As you may have read on other topics, I started Nebido 1000 mg injections this morning.

Does anyone have any experience of using this injection?

From what I understand my doctor is planning on checking levels at 10 weeks but he didnt say yet if he would inject again at 6 weeks like it says to do for the loading phase.

Im wondering if he wouldnt do the load due to switching from Testogel which had me at 18.2nmol?

also for anyone that has used what kind of levels did you have in weeks 10-11-12? before the next injection.

 

[cjw2021]

Most docs don't use Nebido here but I am curious how your estrogen levels are on it.

 

[Misc]

wow 6 weeks isnt good at all.

just like any test its best to try and keep frequent injections to keep the levels stable. with longer esters you can get away with spacing them out farther. since the halflife is around 21 days you could prob do every week injections and have very stable levels.

 

[TR2838]

wow 6 weeks isnt good at all.

just like any test its best to try and keep frequent injections to keep the levels stable. with longer esters you can get away with spacing them out farther. since the halflife is around 21 days you could prob do every week injections and have very stable levels.

I agree.. I would not go with this protocol.. You will experience extreme hormonal swings. I would say it's better to have constant low T than go through that roller coater ride. In my opinion: Dont do it unless you get ATLEAST once a month shots

 

[DoubleEdge]

wow 6 weeks isnt good at all.

just like any test its best to try and keep frequent injections to keep the levels stable. with longer esters you can get away with spacing them out farther. since the halflife is around 21 days you could prob do every week injections and have very stable levels.

You don't understand. Nebido is long lasting thereby providing more stable testosterone levels. It doesn't require you to take it weekly.

I've personally been on nebido very recently and felt very well on it for 2months.

If I needed it I would do it again.

Here is an article describing how it works.

Comparison of kinetics, efficacy and safety of the long-acting testosterone undecanoate formulation with standard testosterone enanthate

 

[Vigilante]

Out of interest why did you stop taking it double?

at the moment I said to my doc I wanted to do a trial on it, im seeing him today to discuss the finer details like when next shot will be and if he wants to do the loading phase with a 2nd shot after only 6 weeks.

I also want to try agree some range for the trough level with him, say he does blood work on 10 weeks I dont really want that level going too low or I will be getting symptoms yet again.

So yeah trail and error, if it dont workout I guess ill force him to go Enanthate but thats 2-3 weekly in his head too.

 

[cjw2021]

how much nebido did he give you?

 

[TR2838]

You don't understand. Nebido is long lasting thereby providing more stable testosterone levels. It doesn't require you to take it weekly.

I've personally been on nebido very recently and felt very well on it for 2months.

If I needed it I would do it again.

Here is an article describing how it works.

Comparison of kinetics, efficacy and safety of the
long-acting testosterone undecanoate
formulation with standard testosterone
enanthate

I'm pretty skeptical of studies paid for by the manufacturer. Also, the Grammar in this study is horrible! They can't have some one proof read their work before publishing the study?
Everything I have read on Nebido states that the halflife is approx 21days.. Injecting every six weeks will get your trough levels very low. IMO

 

[cjw2021]

nebido i think is just the undecanoate ester...

 

[Misc]

You don't understand. Nebido is long lasting thereby providing more stable testosterone levels. It doesn't require you to take it weekly.

I've personally been on nebido very recently and felt very well on it for 2months.

If I needed it I would do it again.

Here is an article describing how it works.

Comparison of kinetics, efficacy and safety of the long-acting testosterone undecanoate formulation with standard testosterone enanthate

I dont think you understand what i said. i stated the halflife is roughly 21 days. weekly injections would keep your test levels very stable. im not saying its necessary to do weekly injections im just saying its much better than taking it once every 6 weeks or 2 months in your case.

it doesnt matter what kind of ester your taking. frequent injections is the best way to keep your test levels stable. longer half life just = less frequent.

nebido i think is just the undecanoate ester...

Yup it is.

 

[Vigilante]

how much nebido did he give you?

1000mg - 4ml

As I thought he isnt gonna load after 6 weeks because of my already mid range level from the gels, so hes gonna retest me at 10 weeks. he plans on injecting again at 12 but assuming 10 or even 9 would be better.

 

[TR2838]

I guess you're ignoring the suggestions you get. I don't know why people start threads looking for info/suggestions just to ignore them when you get them???

Have fun w/ your rollercoaster ride

 

[Vigilante]

I guess you're ignoring the suggestions you get. I don't know why people start threads looking for info/suggestions just to ignore them when you get them???

Have fun w/ your rollercoaster ride

???

I get the feeling you are in USA? come to the UK and try get the NHS to do exactly as you request?

I consider this my 1st step on the ladder nothing more nothing less. Time will tell how it works or doesnt work, if it doesnt work then I can push my doctors that bit harder.

Not even sure where you drag this 6 weeks thing from either all the studies I have read were with 10-14 week injection periods other than an intital 6 week loading phase to bring levels up quicker and the 10-14 is a maintain. From what I have understood 10-14 weeks is when the trough levels will kick in but it will still be in the low-normal level isnt that what happens on all injections wether it be Nebido, Enanthate, Cyp, Prop. There is no way in hell my doctor would agree to weekly injections. I doubt I could even convince an Endo over here to take that route.

According to the Testosterone For Life book by Abraham Morgentaler Nebido injections provide good T levels for 10 weeks.

 

[TR2838]

Don't you guys have Hormone Replacement Therapy (HRT) clinics over there? I can not see a Legit clinic allowing you to go so long in between shots; at least I hope they wouldn't. The half-life is 3 weeks.. How would any doctor administer testosterone with a 21 day half life, every 12 weeks!?

This is your breakdown of the half life

Day 1- 1000
21 days- 500
6 wks- 250
9 wks- 125
12 wks-62


Do you want to be on near empty test levels for 3 plus weeks? I'm typing this out for your own good.. I know from experience what it feels like to get injections past the esters half life..
I'm on test cyp (half life 7 days).. If I go more than 5-6 days without a shot, I feel like I'm ready to jump out of my skin!
Also, I don't think its a good idea to do trial shots.. If you have low T, it needs to be treated.. But, if your going to treat it, it needs to be treated properly! If your treated improperly, you will feel horrible..
If you have info that contradicts this please post it.. I am always up for learning.

 

[cjw2021]

I think it's mostly socialized over there. It'll be like that here if the Obama robots have their way. Nebido is standard Hormone Replacement Therapy (HRT) therapy over there now I think.

 

[Misc]

ok did you come here for advice or to argue the point of how to properly administer test undecanoate?

if i were you id ask the doc to keep the amount the same but to administer it more frequently at lower dosages. i don't see how he can be opposed to that. its not like your asking for more test. so if hes giving you 1000mg for 10 weeks then just space it out 100mg a week or even 200mg every two weeks.

 

[Vigilante]

Quite franky all im seeing is contradicting arguments so far.

Im by no means an expert on Injetcions of testosterone, but from what I have understood from the studies Nebido has the undecanoate ester and castor oil which is supposed to slow down the half life more?

Do any of you that are against this actually have experience using Nebido? Its not even approved by the FDA is it?

Who is arguing how to administer Nebido by the way?

As far as him splitting the dose to 100mg per week, since thats not what the textbooks say over here i would need to drug my doc or brainwash him to get that.

My choices really at this moment in time are:

Testogel
Testim
Nebido
TE - 2 weekly

I could force to see an Endo I guess if things dont work out but knowing the NHS I wouldnt get any better answers from one of those here either.

Paying private isnt really an option either, havent worked in ages due to depression/anxiety/ocd/fatigue and the rest of the syptoms iv had and with twins on the way too money is kinda tight.

I cant do anything anyway right now until 10 weeks and a blood test result has come back, from then on yeah I can maybe negotiate further.

If this is a so bad way of doing things though im wondering why these studies of TE vs Nebido have Nebido winning over a period of time.

Is it known as Aveed over there?

 

[Motiv8ed]

I don't think anyone here is against the use of Nebido, just its injection intervals.

I understand you have researched this product and have come to the conclusion, based on the studies, that the recommended injection rates are fine. If you look at the article you posted you'll notice that it says that patients can avoid the normal doctor visit every 2 weeks for an injection of test because Nebido lasts longer. I underlined 2 weeks for a reason. An injection of the typical esters of test, with an injection interval of every 2 weeks, will put anyone on a roller coaster ride of high and low hormone levels, due to its half life. It is therefore deduced by the members here that the recommended injection intervals of Nebido will put you on the same roller coaster ride based on its own half life.

Many of us on this forum have gone through these terrible hormone swings, and accompanying effects, because our doctors prescribed test at intervals that are too far apart. We're just trying to warn you of the same issue because it appears the Docs across the pond administer test the same way.

Good luck brother.

 

[CHIP WADOWSKI]

I DIDN'T BOTHER TO READ THE WHOLE ARTICLE, CAUSE I HAVE NO ONE HERE TO READ IT TO ME..... BUT I THINK I DID SEE THE WORD "UNDECANOATE" SOMEWHERE IN THERE. THE FDA PULLED TEST UNDECANOATE OF THE MARKET A FEW YEARS AGO, JUST ABOUT THE SAME TIME THAT THEY PULLED SUSTANON 250 AND FLUOXYMESTERONE (HALOTESTIN).... SO REALLY THE WHOLE DISCUSSION IS A MOOT ISSUE. WE NEED TO PLAY THE GAME BY THE RULES THAT THE FDA SETS AND THEN WE ARE ALL SAFE.

 

[Vigilante]

I don't think anyone here is against the use of Nebido, just its injection intervals.

I understand you have researched this product and have come to the conclusion, based on the studies, that the recommended injection rates are fine. If you look at the article you posted you'll notice that it says that patients can avoid the normal doctor visit every 2 weeks for an injection of test because Nebido lasts longer. I underlined 2 weeks for a reason. An injection of the typical esters of test, with an injection interval of every 2 weeks, will put anyone on a roller coaster ride of high and low hormone levels, due to its half life. It is therefore deduced by the members here that the recommended injection intervals of Nebido will put you on the same roller coaster ride based on its own half life.

Many of us on this forum have gone through these terrible hormone swings, and accompanying effects, because our doctors prescribed test at intervals that are too far apart. We're just trying to warn you of the same issue because it appears the Docs across the pond administer test the same way.

Good luck brother.

No doubt that is correct, my main problem however is convincing someone to treat me like that here, nebido is my 1st injection of any testosterone after 3 months of messing around on Androgel.

Im gonna write down exactly how i feel each day over the next 10 weeks until the blood test and if I do feel worst towards those last few weeks I will ofc be arguing the case again.