Fact sheet: AF's AIFM (Aromatase Inhibitor)

Macro, my gyno has been acting up lately (off cycle) and it seems like this could help but are there any other added benefits?

This will raise my natural test? Is there time limit to how long someone should use this and perhaps any side effects (other then irritation) from prolonged use.
 
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aProtege said:
Macro, my gyno has been acting up lately (off cycle) and it seems like this could help but are there any other added benefits?

This will raise my natural test? Is there time limit to how long someone should use this and perhaps any side effects (other then irritation) from prolonged use.


increased test and free test.
yes it will raise your natural test.
with low doses off cycle it can be used for very extended periods. though reccomend 8 weeks on 2 weeks off (allows you to see where you are at(naturally) and cuts potential irritation issues to nil.)
 
Using AIFM with HRT. Without AIFM oestradiol was twice the upper range (212) now its smack bang in the middle (68). This was 4 hrs after one spray.

I generally take it 1 or 2 sprays a day.

Macro what is its half life I need to know whether to take it twice a day. I get puffy/soft nipples about 12 hours later but if it has a 24 hour action to keep it at the value I measured in the bloods I dont want further supression.

Bloody clinic caried out no requested CV, Kidney or LFTs so still have no assessment of any other risks
 
Maxgain said:
Using AIFM with HRT. Without AIFM oestradiol was twice the upper range (212) now its smack bang in the middle (68). This was 4 hrs after one spray.

I generally take it 1 or 2 sprays a day.

Macro what is its half life I need to know whether to take it twice a day. I get puffy/soft nipples about 12 hours later but if it has a 24 hour action to keep it at the value I measured in the bloods I dont want further supression.

Bloody clinic caried out no requested CV, Kidney or LFTs so still have no assessment of any other risks

You should keep your sprays 12 hours apart. It lasts a couple hours but then your body has to make new enzymes and that takes time as well.
Thanks for posting your blood results. If you get a chance please post this on the AIFM updates? thread on our board as well. People like to know that what they're using is working.
 
the peak release is over 4-8hrs, this will vary due to dermal thickness, adiposity and site of application, though there is residual release that lasts over 24hrs. Twice a day dosing is reccomended for even suppression.
 
Can AIFM effect androstenedione levels at all.
Im on HCG with testosterone replacement therapy (TRT) and androstenedione was high so halved the dose and concurrently introduced AIFM for oestrogen and now my androstenedione is double that when i was on the higher dose of HCG.

?????????????????????????????????????????
 
Maxgain said:
Can AIFM effect androstenedione levels at all.
Im on HCG with testosterone replacement therapy (TRT) and androstenedione was high so halved the dose and concurrently introduced AIFM for oestrogen and now my androstenedione is double that when i was on the higher dose of HCG.

?????????????????????????????????????????

it can raise androstenedione levels. androstenedione is a test and estradiol precursor and you are blocking one of the pathways, and there are rate limited enzymes for conversion to testosterone. though the AIFM may cross test as androstendione, as may its metabolites. You are also supplying DHEA which is a substrate to androstenedione, though it should not be that significant alone, however combined with these other factors.

how old are you? if HCG is driving production but the enzymes are lacking you will end up with a greater pool of substrate (in this case androstendione).

also people have reported significantly stronger response to HCG when using AIFM (you might want to reduce your dosage, again)


do you have copies of your blood work, it would be interesting to see the whole picture (all hormones tested) as well as dosages of your testosterone replacement therapy (TRT). it would make it easier to evaluate.
 
macro said:
it can raise androstenedione levels. androstenedione is a test and estradiol precursor and you are blocking one of the pathways, and there are rate limited enzymes for conversion to testosterone. though the AIFM may cross test as androstendione, as may its metabolites. You are also supplying DHEA which is a substrate to androstenedione, though it should not be that significant alone, however combined with these other factors.

how old are you? if HCG is driving production but the enzymes are lacking you will end up with a greater pool of substrate (in this case androstendione).

also people have reported significantly stronger response to HCG when using AIFM (you might want to reduce your dosage, again)


do you have copies of your blood work, it would be interesting to see the whole picture (all hormones tested) as well as dosages of your testosterone replacement therapy (TRT). it would make it easier to evaluate.

Heres a post I mad on another site about latest Hormone Replacement Therapy (HRT) results.
Thanks a lot for any input
Maxgain

Im 22 and am on testosterone replacement therapy (TRT). testogel 5ged and hcg 250iu e3d and AIFM topical spray for oestrogen.

I received some blood tests today and need some guidance.

1) First the trt.

Total T = 21 (8 - 33)
Androstenedione: 28 (2.8-10) ***********
Oestadiol 68 (0-130)

Ok so previously i was on 500 iu HCge3d and the gel and following advice on the board I dropped to 250iu as oestradiol was way too high at 216 (o-130) Test was 31 (8-33)

One would think the drop in test can be expeced as the HCG dropped but what i can not explain is the huge androstenedione reult which is much higher -nearly double- than when I was on 500iu HCG. It is really confusing me.

Given the Test levels and the androstenedione I believe the hcg is having the effects and that the gel is not getting through. I am therefore dropping this and changing to T injections 100mg/wk. Ethanate is not licensed here but I am stil trying to get it. If not it will be nebido 200mg/2wks.
Should the HCg be lowered in dose??

Other points why I am not satisfied with the gel is a weak libido. NEVER do I get a morning errection and it takes a lot of stimulation to achieve one. Also DHt which was not tested tough asked is prob high as I am thinning a smallbit on crown. Got prescribed Nizoral for that may have to look into rogain -more money- not keen on alpha reductase inhibitor at my age.


2) IGF-1 = 198
This is low as range is up to 400 and some labs show even up to 700 dep on age.
Previously I was on Trans D-tropin and this was successful and got it up to 380. This was too dear though and tried an injectable gaba but obviously no good.
ant get HGH etc no insurance here as in America need a consultant.
Am now thinking of trying a product called symbiotropin (effervescent tablets)

I notice the difference from the lower levels, loss energy strength and poor sleep now.

3) Thyroid

TSH previously was between 4-7 taken many times. Was planning on going on Armour but now TSH has dropped to 3.5 and Free T4 is 16.5 (11-21) so that is out.
I know over 3 still seems high but the doctor does not think i need to go on it.
I need to point the reason for this is the addition of I have a very fast metabolism and am never cold compared to most so symptoms dont seem present though outer eyebrows do thin.
No T3 given by labs though asked for.
(Dont get me started they left out cardiac kidney liver and electrolyte tests the idiots)
 
aifm gets my thumbs up, good product. If you have extremely sensitive to estro and am running a large cycle I would reccomend letro. This stuff is great post cycle anytime and also strong enough for most cycles that people run. That is why I take it and put other people on to it.
 
younger users of HCG will experience a much greater surge in androstenedione. yours is probably higher still because of low production of 17 beta-hydroxysteroid dehydrogenase type 3 (which converts androstenedione to testosterone) and also because you are blocking the aromatase pathway.

you may want to lower the HCG dose. you should try to get injectable test. you could try applying AIFM over your androgel. it would increase uptake and should not be a problem.

nizoral is a good option. rogaine is appears to be a lifelong commitment, but earlier use appears to be better.

you should be able to get HGH or IGF-1 from a euro source (not really a proponent of igf-1, too little is really known about it)

will think on the thyroid issue... and get back to you.
 
Macro thanks for your input.

Since I have got the bloods I am now on test enthanate 125mg 0.5ml every week (prob bout 110 lose some in preparation)

I follow Swales testosterone replacement therapy (TRT) protocol and take the hcg 2 injections /week the 2 days before the test injection.

At the moment its 250iu/ injection but i would be inclined to drop it to 100ius with the recent result.

***********My question would be that with 500iu however test was good and andro was half it is now. cant explain it and would wonder if AIFM is perhaps an inhibitor of of 17 beta-hydroxysteroid dehydrogenase type 3 as well as it seemed to be grand before it????????????????????????????

I agree with you on the IGF-1 would not be comfortable taking it. I have sourced jintropin for a reasonable price for hgh and have been on it 2 weeks. Much better sleep and noticed an increae in bench of 5kgs within the week -put me back where i was a few months ago was declining and could not improve-.
I take 2iu ed no days off.
Only thing is i think it reduced the thyroid as my meatabolism is slower as i put on weight/fat that week with a normal slow bulk diet.

I went for the minoxidil now as this is the greatest chance of regrowth now and would regret not with a big bald patch in a few years. I use kirklands so is fairly cheap.
 
Maxgain said:
***********My question would be that with 500iu however test was good and andro was half it is now. cant explain it and would wonder if AIFM is perhaps an inhibitor of of 17 beta-hydroxysteroid dehydrogenase type 3 as well as it seemed to be grand before it????????????????????????????

no. AIFM as well as other steroidal AI's (and androstenedione itself) upregulate 17 beta-hydroxysteroid dehydrogenase production
 
use of an aromatase inhibitor will usually increase response to HCG (until of course you suppress estrogen too low)
 
what are the best places to aplly it again. I use my wrist and my whole forearm. but i also nair my quads and my shins so i was thinking maybe since the nair strips off the dead skin that my quads and shins would be the next best place. ?

by the way my sex drive has been kinda shitty even thou im on 600 of test. I just ordered another bottle of aifm so ill try that and see if it helps. i wonder if its from coming of an ssri i was on for years

or related to me using topical anti androgens or nizerol, i know they are suppost to only work locally but i use them with rentin a to help absorbtion and i was thinking maybe this makes them enter the blood stream. i know its off topic but any thoughts.
 
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macro do me a favor if u get a chance. Some one else asked a post cycle therapy (pct) question in this thread after being shut down for a long time. Im interested in your input since i have been on for a while and plan on coming off in a few months.


i know u know ur shit when it comes to AI's and serms so if u get a chance the thread is http://steroidology.com/forum/showthread.php?t=109472
 
simpllyhuge said:
what are the best places to aplly it again. I use my wrist and my whole forearm. but i also nair my quads and my shins so i was thinking maybe since the nair strips off the dead skin that my quads and shins would be the next best place. ?

by the way my sex drive has been kinda shitty even thou im on 600 of test. I just ordered another bottle of aifm so ill try that and see if it helps. i wonder if its from coming of an ssri i was on for years

or related to me using topical anti androgens or nizerol, i know they are suppost to only work locally but i use them with rentin a to help absorbtion and i was thinking maybe this makes them enter the blood stream. i know its off topic but any thoughts.


quads and shins are good as is chest, riblets (serratus), and abs. Most of the torso is good.

if you E levels are too high that could be causing a problem, likely via increase in prolactin though E's effects are wide and there are many things that affect libido. coming off an SSRI usually helps with libido, though there may be rebound or lingering effects which do cause libido issues.

that is a definite possibility, you really want to be careful trying to increase absorption of anti-androgens.
 
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