Igf?

[irishmaniac]

where might i be able to get some info on IGF? I have a few friends running it right now and they swear by it..... what is you guys opinion on it?

1) how and when do you run it?

2) how long do you run it?

3) are the results worth it? (i hear u inject the muscle group you are hitting for the day to make em grow?)

 

[irishmaniac]

no body has anything to say? strange..............

 

[MS1605]

Irish, I posted some questions on IGF about a week and a half ago and same thing, bumped it a few times with no results. I ended up talking to someone via PMs about it. I suggest going elsewhere for some good IGF info. Or doing some deep searches on here from past conversations.

 

[1badmofo]

50 mcg IM PWO split bilaterally with some carbs, run 1 bottle then take a couple weeks off. IMO results are somewhat subtle compared to steroids, but it is real tissue(possibly hyperplasia) growth and I seemed to notice a localized effect on my arms despite that I don't believe in spot injections for steroids igf seems to work locally, hence splitting the shots bilaterally.

 

[Teutonic]

Yeah..it s both an expensive and controversial compound...it ll be my next move...I ve calculated it at approximately300 plus a month for 4 iu s a day..for a year...with 6 month s being a minimum to see results..
I don t think there s any doubt it works...and it appears using slin with it is a way to enhance it even more...but now we re opening up a whole new pandora s box of issues..no thank s.
If I do it it would be at 4 iu s a day with a testosterone replacement therapy (TRT) dose, with some 8 week Blasts.. for a year..
You can look under Life Extension Clinic s in Florida and see what they claim..and what they charge.

 

[MS1605]

Yeah..it s both an expensive and controversial compound...it ll be my next move...I ve calculated it at approximately300 plus a month for 4 iu s a day..for a year...with 6 month s being a minimum to see results..
I don t think there s any doubt it works...and it appears using slin with it is a way to enhance it even more...but now we re opening up a whole new pandora s box of issues..no thank s.
If I do it it would be at 4 iu s a day with a testosterone replacement therapy (TRT) dose, with some 8 week Blasts.. for a year..
You can look under Life Extension Clinic s in Florida and see what they claim..and what they charge.

I just read an article last week written by a DOCTOR about using slin, IGF-1 and test in a cycle for athletes. Im going to try and find it. it was really good.

 

[Massive123]

Secret of Insulin-Like Growth Factor Revealed.
Bodybuilders take insulin-like growth factors (IGFs) to promote muscle-building, and scientists have studied their effects on muscle and their role in the growth and spread of cancer, but experts had been unable to uncover the secret of how IGFs work on muscle cells, until now.

Insulin-like growth factors are a type of hormone that is secreted from many different cells. The two main IGFs are IGF-I and IGF-II, and both resemble insulin in structure. IGFs work by attaching themselves to receptors on target cells. This triggers a series of reactions that direct the cell to do something.

When muscle is being formed, the binding of IGF to a receptor can trigger one of two responses from the myoblasts, which are immature cells that develop into muscle tissue. One, the cells divide; or two, the cells become specialized. Once a muscle cell takes one course of action, it cannot take another action at a later time. Experts have long wondered how stimulation of the same receptor by the same hormone can trigger two very different responses, and now Cumming Duan, a molecular biologist at the University of Michigan, believes he and his team have found the answer, and the answer is oxygen.

It appears that the ability of myoblasts to respond is determined by the amount of oxygen that is available. When there is an adequate amount of oxygen, IGF promotes differentiation of muscle cells, but when oxygen levels are below normal, IGF promotes muscle cell division. When oxygen is low, a factor called the HIF-1 complex reprograms the steps that ultimately control the cell’s response.

These findings may be useful in several areas, including muscle loss (atrophy) as people grow older. Duan notes that “If we can find a way to affect IGF signaling, we may be able to stop or reverse the loss.” The researchers also believe their findings could result in new treatments for muscle-wasting diseases, shed light on the role of IGFs in cancer, and possibly lead to new ways to treat cancer.

SOURCE:
University of Michigan news release, Mar. 15, 2010
posted by s.b.c at 09:48 0 comments
labels: anabolic steroids, asian bodybuilder, steroids, steroids blog, steroids uk

 

[hatesnoobs]

Interesting... are IGF compounds fairly new to bodybuilders?

 

[irishmaniac]

Secret of Insulin-Like Growth Factor Revealed.

VERY interesting read.

 

[irishmaniac]

You can look under Life Extension Clinic s in Florida and see what they claim..and what they charge.

its funny.... i live in FL, and it seems everything is based outa here. UGLs, TRT/HRT clinics, u name it, we got it!

 

[Massive123]

Interesting... are IGF compounds fairly new to bodybuilders?

Yea I don't think it's been around for too long. Put it this way- they didn't have it in Arnolds days... I can't say for sure when it arrived on the scene but my guess is within the last decade or so

 

[irishmaniac]

i called up a friend of mine today who is currently running IGF...... i asked him what all he sees from it (hes been on it for quite some time, hes also 25yrs old).... he told me he has noticed his biceps/triceps increase in size, along with his pecs. I guess what he does is injects himself right after the gym?

 

[MS1605]

i called up a friend of mine today who is currently running IGF...... i asked him what all he sees from it (hes been on it for quite some time, hes also 25yrs old).... he told me he has noticed his biceps/triceps increase in size, along with his pecs. I guess what he does is injects himself right after the gym?

Yes, The consensus is 15 minutes after training you take it bilaterally in the muscle group you worked. Thats the ONLY drawback I see. Your either pinning it in a dirty ass gym bathroom or in your car after a long workout. I dont want to sound like a germaphobe but you got to make sure to keep clean while doing it.

 

[drewbolic]

found some more info on igf-1.
This is Palumbo's theory

IGF-1 Info from Dave Palumbo's column (Feb Issue)
OK. You guys better appreciate me typing this out for you. This is the info he shared after being asked a question in his column in MD this in February.

Yes it is long.... but it took me for ever to type it out.... and it is a GREAT read!! So get reading!

----------------------------------------------------

IGF-1, as the name implies, is an extremely anabolic hormone that has insulin-like actions (i.e. it shuttles nutrients, specifically amino acids and glucose, into the muscle cells where they can be synthesized into new muscle tissue.) When bodybuilders take growth hormone injections, they are not injecting a pure growth stimulus - they are taking a stimululating or releasing factor. It is for this reason that high dosing of GH is not necessarily going to result in more growth. Growth is limited by the amount of IGF-1 the liver can produce in response to any given dosage of GH. IGF-1 has been synthetically synthesized (using similar technology as that used to make GH) to circumvent the shortcomings that are associated with GH-mediated IGF-1 production in the liver. If we try to maxamize the output of IGF-1 in order to further increase muscle mass, it becomes much easier to just administer IGF-1 directly. In persuit of this goal, scientists began to study the pysiology and pharmacology of the hormone IGF-1. What they found was that IGF-1 circulates in the bloodstream (99 percent) bound to specific binding proteins. It is the remaining unbound or free (1 percent) of the IGF-1 that causes the anticipated muscle cell hyperplasia. (The bound 99 percent is essentially wasted).In order to combat this phenomenon of the binding proteins "stealing" our precious IGF-1, scientists have chemically altered the original IGF-1 molecule and have added chemically bound side chains, thus creating a new hormone known as LONG R3 IGF-1. (The long R3 refers to the three long side chains that have been added to the original molecule). These large, space-occupying, side chains are attached to the IGF-1 molecule to prevent these blood born binding proteins from "snatching" up and inactivating the IGF-1. For the last several years, most bodybuilders who were privy enough to get their hands on synthetically produced IGF-1 have been using the Long R3 IGF-1 variety thinking it will last longer in your body (12 hours opposed to 20 minutes). Also, that more of it will be available (unbound) to help build and repair muscle. The theory is essentially correct, however, what bodybuilders started noticing after extended usage of Long R3 IGF-1 was that it stopped working as effectively after about 4 weeks.
I began to keep notes and I worked out a system by which bodybuilders would inject Long R3 IGF-1 [about 10-20 mcg] within 15 mins following a workout so the IGF-1 could circulate and locate these newly produced IGF-1 receptors on the damaged muscle cell membranes. (These new receptors appear as a direct result of damage induced by intense weight training and muscular trauma). It is at these damaged cells that the body increases the number of IGF-1 recpetors so it can signal where the muscle repairs must be performed. (This is why muscle cells grow, preferentially, and not bone tissue or internal organs, as rumoured).
However, as the dosage of IGF-1 increases above the suggested 10-20mcg per day, the IGF-1 muscle cell receptors become saturated and now all this excess IGF-1 goes straight to the highest naturally occuring concentration of IGF-1 receptors - The extremisties (i.e feet, hands and facial bones). Thereby, side effects such as shoe and hand size increases and facial bone thickening can occur. Additionally, high Long R3 IGF-1 dosing will lead to decreases in muscle cell IGF-1 receptors, thus diminishing the results seen with Long R3 IGF-1 usage over time. In summation, empiracal evidence has shown that 10-20mcg per day of Long R3 IGF-1 causes significant muscle cell hyperplasia and will continue to do so extremely effectively for approximately 30 days.
Even with conservative amounts of Long R3 IGF-1, the hormone still stops functioning after a perios of time. Therefore, I usually suggest that bodybuilders take a two to four week "holiday" off the Long R3 IGF-1 after every 30 day course of administration.

 

[hatesnoobs]

So does this stuff have any sides in the range of 10-20mcg ?

 

[1badmofo]

I started it at 11mcg and worked up to 50mcg, liked 50mcg way better. I never had any sides, some people could have headaches or blood sugar issues but it's not very common

 

[hatesnoobs]

I started it at 11mcg and worked up to 50mcg, liked 50mcg way better. I never had any sides, some people could have headaches or blood sugar issues but it's not very common

Were you running it by itself? How much did you gain?

 

[1badmofo]

yes I was running it by itself so I could see how it affected me, I didn't gain or lose any weight per say because I was on a maintenance diet, but I did put noticeable size on my arms. I'm 6'3" and I have lanky arms and this really helped my biceps and triceps pop and fill out. They felt full 24/7 on IGF. I don't take measurements but it was a visible difference. If I recall Needsize had a similar experience. I think he said his arm measurements had not changed for years until he ran IGF. I will definitely run it again soon.

 

[irishmaniac]

yes I was running it by itself so I could see how it affected me, I didn't gain or lose any weight per say because I was on a maintenance diet, but I did put noticeable size on my arms. I'm 6'3" and I have lanky arms and this really helped my biceps and triceps pop and fill out. They felt full 24/7 on IGF. I don't take measurements but it was a visible difference. If I recall Needsize had a similar experience. I think he said his arm measurements had not changed for years until he ran IGF. I will definitely run it again soon.

hmmm..... this is what i like to hear!!!!!!!
one would assume if injected into pec, pec size would increase as well?