Perception
New member
Eyes back to normal yet?
Eyes back to normal yet?
BassP you got pics to post?
Even 75mg/day is a high dose. Chavo who's selling it on Pro Muscle recommended a dose of 1-3 mg/kg/day "based on current clinical trials," so that's what guys have started using it at. However, when pressed for what those clinical trials were, he had nothing to say, because they don't exist. The only clinical trials on S-4 are the ones that GTx is doing for Ostarine (their brand name for S-4). But their clinical trials used up to 3mg TOTAL per day, not per kg of bodyweight per day. That's a huge difference. The dosing for this chemical has been WAY too high, because one of the primary people selling it does not understand the research.
This preliminary study on S-4 in rats found that anabolism in muscle was maxed out at around 0.75 mg or 2.82 mg/kg per day (see results in the levator ani in this figure). When corrected for body surface area and converted to dosing for humans, the dose that maxes out the anabolic response is around 0.46 mg/kg. In a 200 lb male, that works out to about 40 mg/day. That may sound low, but it's 13 times higher than the highest dose they used in the clinical trials. I think that the yellow vision and impaired night vision that people are reporting are side effects of acute overdose of S-4. You sure as hell don't need hundreds of mgs per day.
Further, the animal research on S-4 shows that at higher doses, it DOES suppress LH and testosterone levels. There was no effect on these parameters at 3 mg per day in the clinical trials, but you can bet that if the dose gets higher, you'll start to see HPTA suppression.
Even 75mg/day is a high dose. Chavo who's selling it on Pro Muscle recommended a dose of 1-3 mg/kg/day "based on current clinical trials," so that's what guys have started using it at. However, when pressed for what those clinical trials were, he had nothing to say, because they don't exist. The only clinical trials on S-4 are the ones that GTx is doing for Ostarine (their brand name for S-4). But their clinical trials used up to 3mg TOTAL per day, not per kg of bodyweight per day. That's a huge difference. The dosing for this chemical has been WAY too high, because one of the primary people selling it does not understand the research.
This preliminary study on S-4 in rats found that anabolism in muscle was maxed out at around 0.75 mg or 2.82 mg/kg per day (see results in the levator ani in this figure). When corrected for body surface area and converted to dosing for humans, the dose that maxes out the anabolic response is around 0.46 mg/kg. In a 200 lb male, that works out to about 40 mg/day. That may sound low, but it's 13 times higher than the highest dose they used in the clinical trials. I think that the yellow vision and impaired night vision that people are reporting are side effects of acute overdose of S-4. You sure as hell don't need hundreds of mgs per day.
Further, the animal research on S-4 shows that at higher doses, it DOES suppress LH and testosterone levels. There was no effect on these parameters at 3 mg per day in the clinical trials, but you can bet that if the dose gets higher, you'll start to see HPTA suppression.
Most def an improvement. After all of this would you do it again?
I see on another board a log that the guy is doing 10mg ed and is getting good results.