cybrsage
New member
Not really sure where this should go. It is not an anabolic, it is a nootropic, a cognitive enhancer. As you probably guessed, it makes you think faster, clearer, and hopefully better. It is also called GVS-111 or N-phenylacetyl-L-prolylglycine ethyl ester (though I doubt that last one is used in conversation much). It is a patented item and is owned by a Russian company.
Noopept does nothing on its own, the body converts it to cycloprolylglycine, which is then used by the body's acetylcholine system and it controls the AMPA receptors. AMPA receptors control the fast synaptic transmission in the central nervous system. If we can make them work better, faster, and stronger, we have a winner on our hands and a brain (cognitive) enhancing drug.
Other than help you think faster, clearer, and better, what else does it do? I am glad you asked! It appears to be VERY good for helping to protect against Alzheimer's Disease. Here is a snippet:
Take note that this was only on animal studies, but it is exciting nonetheless! All the studies, so far, are only on non-humans.
It also apparently is good for helping to control (or prevent) specific types of diabetes by normalizing levels of GLP1 insulin in the blood.
And another study, which compares Noopept to an already existing and in use treatment drug:
And another study saying how wonderful Noopept is for diabetes:
They studied the two main experimental lab mice types for how well noopept helped them in a maze. It did nothing for the one type but did wonders for the other:
The C57BL/6 mice are not prone to anxiety, they do tend to try to bite the handlers more often than other types. They are more susceptible to pain (probably why they bite so much) and analgesics have almost no effect on them. They also become addicted quickly and will voluntarily drink alcohol. The BALB/c mice are highly prone to anxiety and respond to it by becoming more and more aggressive. They also are very bad at navigating through unknown areas, which causes their anxiety levels to go up. So the study basically showed that noopept is great for reducing anxiety due to decision making and greatly increased the ability to navigate the maze - at least if you are of the correct type of mouse. It does not say why the differences were seen. I would hazard to guess it has something to do with the resistance to analgesics the C57BL/6 mice have.
Another study agrees with them on this, and goes a little further and says:
But is it legal? Well, that depends on where you live. Provided this site is correct (and I have not seen anything showing otherwise), here is a small list of legal/illegal status:
So there you have it. We know how it works and why. We know it works in mice and we know it not only improves cognitive ability and reduces anxiety, but it also helps to normalize diabetes in mice. VERY exciting stuff!
Noopept does nothing on its own, the body converts it to cycloprolylglycine, which is then used by the body's acetylcholine system and it controls the AMPA receptors. AMPA receptors control the fast synaptic transmission in the central nervous system. If we can make them work better, faster, and stronger, we have a winner on our hands and a brain (cognitive) enhancing drug.
Other than help you think faster, clearer, and better, what else does it do? I am glad you asked! It appears to be VERY good for helping to protect against Alzheimer's Disease. Here is a snippet:
Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation | Journal of Biomedical Science | Full TextConclusions
Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of A***946; through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway. Moreover, neuroprotective properties of noopept likely include its ability to decrease tau phosphorylation and to restore the altered morphology of PC12 cells. Therefore, this nootropic dipeptide is able to positively affect not only common pathogenic pathways but also disease-specific mechanisms underlying A***946;-related pathology.
Take note that this was only on animal studies, but it is exciting nonetheless! All the studies, so far, are only on non-humans.
It also apparently is good for helping to control (or prevent) specific types of diabetes by normalizing levels of GLP1 insulin in the blood.
https://www.ncbi.nlm.nih.gov/pubmed/25065315Noopept normalizes parameters of the incretin system in rats with experimental diabetes. It is known that GLP-1 increases NGF expression in the insular system. Our results suggest that the increase in incretin activity contributes to the antiapoptotic effect of Noopept on pancreatic ***946; cells. The mechanism for an increase in blood GLP-1 level after oral application of Noopept requires further investigations.
And another study, which compares Noopept to an already existing and in use treatment drug:
https://www.ncbi.nlm.nih.gov/pubmed/24771372In active control group, spontaneously increase glucose level and reduced tolerance to glucose load (1000 mg/kg intraperitoneally) were observed on the next day after the third administration of toxin. Basal glucose level decreased by day 16, but glucose tolerance remained impaired. Noopept normalized the basal blood glucose level and tolerance to glucose load on the next day after administration of streptozotocin. The effect of Noopept persisted to the end of the experiment. At early terms of the experiment, sitagliptin was somewhat superior to Noopept by the effect on baseline glucose level, but was inferior by the influence on glucose tolerance.. By the end of the experiment, Noopept significantly (by 2 times) surpassed sitagliptin by its effect on glucose tolerance.
And another study saying how wonderful Noopept is for diabetes:
https://www.ncbi.nlm.nih.gov/pubmed/23484194We studied the effects of new nootropic and neuroprotective drug Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) in various dosage regimens on the dynamics of glycemia, body weight, and pain sensitivity in rats receiving diabetogenic toxin streptozotocin. In experimental diabetic rats, Noopept alleviated glycemia and weight loss and normalized enhanced pain sensitivity. The normalizing effect of Noopept was most pronounced when it was administered as a preventive agent prior to injection of the toxin. Both preventive and therapeutic administration of Noopept (delayed injections included) significantly weakened the examined metabolic effects of diabetogenic toxin. Possible mechanisms of the antidiabetic action of Noopept are analyzed.
They studied the two main experimental lab mice types for how well noopept helped them in a maze. It did nothing for the one type but did wonders for the other:
https://www.ncbi.nlm.nih.gov/pubmed/25739185The effect of acute, 7-fold and 14-fold noopept (1 mg/kg/day) administration on the dynamics of anxiolitic and nootropic behavioral effects in cross-maze, as well as their correlations with NMDA- and BDZ-receptor density was studied in inbred mice strains, differing in exploratory and emotional status--C57BL/6 and BALB/c. The dipeptide failed to affect the anxiety and exploration activity in C57BL/6 mice at each of 3 steps of experimental session. In this strain the B(max) values of [3H]-MK-801 and [3H]-Flunitrazepam binding changed only after single administration. In respect to BALB/c mice noopept induced both the anxiolitic and nootropic effects reaching their maximum on 7th day. In BALB/c strain the dynamics of hippocampal NMDA-receptor binding corresponds to the dynamics of exploratory efficacy whereas the dynamics of BDZ-receptors in prefrontal cortex was reciprocally to dynamics of anxiety level.
The C57BL/6 mice are not prone to anxiety, they do tend to try to bite the handlers more often than other types. They are more susceptible to pain (probably why they bite so much) and analgesics have almost no effect on them. They also become addicted quickly and will voluntarily drink alcohol. The BALB/c mice are highly prone to anxiety and respond to it by becoming more and more aggressive. They also are very bad at navigating through unknown areas, which causes their anxiety levels to go up. So the study basically showed that noopept is great for reducing anxiety due to decision making and greatly increased the ability to navigate the maze - at least if you are of the correct type of mouse. It does not say why the differences were seen. I would hazard to guess it has something to do with the resistance to analgesics the C57BL/6 mice have.
Another study agrees with them on this, and goes a little further and says:
https://www.ncbi.nlm.nih.gov/pubmed/23025044Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have been evaluated using the exploratory cross-maze test. It was found that BALB/c mice in comparison to C57BL/6 mice are characterized by greater anxiety and lower efficiency of exploratory behavior in the previously unfamiliar environment. All tested drugs clearly improved the exploratory behavior in BALB/c mice only. In BALB/c mice, piracetam, phenotropil, noopept, and semax also reduced anxiety,...
But is it legal? Well, that depends on where you live. Provided this site is correct (and I have not seen anything showing otherwise), here is a small list of legal/illegal status:
https://psychonautwiki.org/wiki/NoopeptLegal issues
U.S.: Noopept has no schedule assigned to it in the U.S., making it unregulated and therefore legally available for anyone in the country to buy, possess and use.
United Kingdom: This drug is illegal under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[2]
Canada: Noopept does not have a Drug Identification Number (DIN), meaning that it cannot be imported for resale or distribution. Noopept is not scheduled nor controlled in Canada, making import for personal reasons legal.
Australia: Noopept is not a Schedule 4 prescription drug nor is it on the list of poisons. It is currently being sold within the country.
So there you have it. We know how it works and why. We know it works in mice and we know it not only improves cognitive ability and reduces anxiety, but it also helps to normalize diabetes in mice. VERY exciting stuff!
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