Generally you start off with small doses on the first time. 40mcg epr day for the first 3 days, then bump it up 20mcg or so up to 140-160mcg per day. Keep an eye on blood pressure & temperature. headaches usually go away within two days or so (but thats why you keep an eye on blood pressure, headaches=high BP). I could go on forever but I think you need to do some research for yourself like I and everyone else on this board has done!