Massive123
Knowledge is Power
I found this on another site in doing my homework on prami. I couldnt find any standardized protocol here so I figured I'd post this up.
Prolactin suppression using Pramipexole
For Prevention: when you are taking something that can cause prolactin issues or when you just want to lower prolactin, for the benefits of lowering prolactin.
0.125 (1/8) to 0.5mg (1/2) per day should generally be sufficient for most users. With prevention slow escalation should not be an issue
For Treatment: When you have ongoing prolactin issues, Gynecomastia flare, or are attempting to regress gynecomastia tissues (ductal, lobular and central gland mass).
0.375 up (3/8) to 1mg should generally be sufficient for most users. Most people will not need over 0.5mg. If you do, then SLOWLY escalate the dose. You still should start at 0.25mg and slowly work up. see bottom for exceptions
doses should be taken in the evening, 2-4 hours prior to bed. For the very low doses, an hour is probably fine. if it keeps you up, take it earlier. If it makes you sleepy "too soon" then take closer to bed. a good number of people will notice niether. taking with last meal of the day may be ideal for a lot of people.
Now for you people that want high end dosing benefits, which are not prolactin suppression. This is a lot more complex, and generally requires a VERY slow progression in dosing to acheive. Clinicals increased the dose by 0.125 every 3-5 days. there will typicallly be side effects for people at various point along the progression. IT IS EXTREMELY IMPORTANT THAT YOU BE AWARE OF THESE BEFORE YOU LAUNCH INTO HIGH END DOSING.
EDIT- IMPORTANT NOTE-
for those that do not have dopaminergic sides, other than "waking up from sleep"-- which is caused by the drop in pramipexole in the plasma and the subsequent surge of dopamine release from the tissues in which they were suppressed, JUMPING the dose up more quickly will generally alleviate this. this is for those for whom interupted sleep is the primary and pretty much only side effect. this applies to treatment and high end dosing (at least until sleep interution abates).
Prolactin suppression using Pramipexole
For Prevention: when you are taking something that can cause prolactin issues or when you just want to lower prolactin, for the benefits of lowering prolactin.
0.125 (1/8) to 0.5mg (1/2) per day should generally be sufficient for most users. With prevention slow escalation should not be an issue
For Treatment: When you have ongoing prolactin issues, Gynecomastia flare, or are attempting to regress gynecomastia tissues (ductal, lobular and central gland mass).
0.375 up (3/8) to 1mg should generally be sufficient for most users. Most people will not need over 0.5mg. If you do, then SLOWLY escalate the dose. You still should start at 0.25mg and slowly work up. see bottom for exceptions
doses should be taken in the evening, 2-4 hours prior to bed. For the very low doses, an hour is probably fine. if it keeps you up, take it earlier. If it makes you sleepy "too soon" then take closer to bed. a good number of people will notice niether. taking with last meal of the day may be ideal for a lot of people.
Now for you people that want high end dosing benefits, which are not prolactin suppression. This is a lot more complex, and generally requires a VERY slow progression in dosing to acheive. Clinicals increased the dose by 0.125 every 3-5 days. there will typicallly be side effects for people at various point along the progression. IT IS EXTREMELY IMPORTANT THAT YOU BE AWARE OF THESE BEFORE YOU LAUNCH INTO HIGH END DOSING.
EDIT- IMPORTANT NOTE-
for those that do not have dopaminergic sides, other than "waking up from sleep"-- which is caused by the drop in pramipexole in the plasma and the subsequent surge of dopamine release from the tissues in which they were suppressed, JUMPING the dose up more quickly will generally alleviate this. this is for those for whom interupted sleep is the primary and pretty much only side effect. this applies to treatment and high end dosing (at least until sleep interution abates).
