I don't know about aromatase production. I have no idea if it is similar to natural and is a daily burst, constantly produced or what. I have medications that elevate an entire class of enzymes that includes aromatase.
I try and slap the levels down to be close to peak test levels. How much is it worth it? We have a range. twice a week may lead to different E levels but that doesn't mean itll be a bad experience if it's close to your normal.