What do your Testicles make besides Testosterone?
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SolomonGrundy
Grrr...tren Good
a little fluid, the rest come from the prostate
Ok I found this:
"The main hormone secreted by the testes is testosterone, an androgenic hormone. Testosterone is secreted by cells that lie between the seminiferous tubules, known as the Leydig cells. The testes also produce inhibin B and anti-Müllerian hormone from Sertoli cells, and insulin-like factor 3 and oestradiol from the Leydig cells."
Wonder how crucial these hormones are in the adult male...
"The main hormone secreted by the testes is testosterone, an androgenic hormone. Testosterone is secreted by cells that lie between the seminiferous tubules, known as the Leydig cells. The testes also produce inhibin B and anti-Müllerian hormone from Sertoli cells, and insulin-like factor 3 and oestradiol from the Leydig cells."
Wonder how crucial these hormones are in the adult male...
Some guys use Human Chorionic Gonadotropin (HCG) for that reason....they try to get the testes to keep making some of all of what was mentioned.
Austinite
New member
This is why hCG plays a vital role in TRT. So that you don't have to worry about everything that's affected. The list of things affected by testosterone replacement therapy (TRT) protocols that lack hCG is ridiculous. Personally, if a doctor refused to prescribe hCG, I would instantly start looking for another doc. That's how important it is.
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Austinite
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Austinite
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Megatron28
Moderator
This has been an ongoing question for me about testosterone replacement therapy (TRT) and I don t know if I have seen a definitive answer. I am on testosterone replacement therapy (TRT) and do not take HCG. I am not planning on having more kids.
Obviously my natty testosterone is completely shut down now -- what little was left of it before I started TRT. But does injecting exogenous Test shut down the other good things your testicles produce? And is there a lab test you can run to confirm any such deficiencies?
Obviously my natty testosterone is completely shut down now -- what little was left of it before I started TRT. But does injecting exogenous Test shut down the other good things your testicles produce? And is there a lab test you can run to confirm any such deficiencies?
gdevine
New member
Common sense; with the use of exogenous testosterone we in effect are causing a self induced organ shutdown, namely the testes.
The testes do a lot more that just produce sperm.
More important, with HPTA suppression we are shutting down the entire hormonal cascade.
HCG, as an LH analog, does a lot more than just keeping the testes functioning
So what happens when a man testicles don't function anymore do to the lack of LH?
The Biggie: Testicular Atrophy. Men will see their testes get smaller over time and hurt constantly along the way. The duration for this event seems to be different in men where younger guys can seem to go longer where mid to older guys see the event happens on a more accelerated scale. Some think it happens to do with the amount of receptors on the Leydig cells...but who really knows.
Sperm production is pretty much halted.
Men's scrotum's will get really tight and pull up against the body causing pain and end up looking like a 5 year old.
The testes are the single largest producer of the hormone Pregnenolone; the mother of all hormones. We need Pregnenolone for so many reasons and while it can be supplemented it's hit or miss on how effective supplementation can be for some men.
Why we need hCG:
1. To produce Pregnenolone; hCG activates the p450 side chain cleavage (p450scc) enzyme which converts cholesterol to Pregnenolone!!!
2. To produce the precursors for DHEA, Estrogen, Cortisol, Testosterone and DHT...back filling the pathways
3. For proper and normal brain function
4. For proper functioning of the testicles
5. If men ever want to restart
6. If men ever want to have children
7. If men don't want balls that end up in a small mass of useless Collagen
8. The list goes on...
In short, hCG keeps the testicles functioning in a normal state and supports all three androgen pathways. It prevents pregnenolone deficiency and supporting all our other CHOL pathways and hormones as well.
The testes do a lot more that just produce sperm.
More important, with HPTA suppression we are shutting down the entire hormonal cascade.
HCG, as an LH analog, does a lot more than just keeping the testes functioning
So what happens when a man testicles don't function anymore do to the lack of LH?
The Biggie: Testicular Atrophy. Men will see their testes get smaller over time and hurt constantly along the way. The duration for this event seems to be different in men where younger guys can seem to go longer where mid to older guys see the event happens on a more accelerated scale. Some think it happens to do with the amount of receptors on the Leydig cells...but who really knows.
Sperm production is pretty much halted.
Men's scrotum's will get really tight and pull up against the body causing pain and end up looking like a 5 year old.
The testes are the single largest producer of the hormone Pregnenolone; the mother of all hormones. We need Pregnenolone for so many reasons and while it can be supplemented it's hit or miss on how effective supplementation can be for some men.
Why we need hCG:
1. To produce Pregnenolone; hCG activates the p450 side chain cleavage (p450scc) enzyme which converts cholesterol to Pregnenolone!!!
2. To produce the precursors for DHEA, Estrogen, Cortisol, Testosterone and DHT...back filling the pathways
3. For proper and normal brain function
4. For proper functioning of the testicles
5. If men ever want to restart
6. If men ever want to have children
7. If men don't want balls that end up in a small mass of useless Collagen
8. The list goes on...
In short, hCG keeps the testicles functioning in a normal state and supports all three androgen pathways. It prevents pregnenolone deficiency and supporting all our other CHOL pathways and hormones as well.
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halfwit
I like turtles.
Not that I'm one to disagree with such a wealth of information being presented, but isn't pregnenolone made in the adrenals? I have no idea how being suppressed due to exogenous testosterone causes this to cease production along with DHEA, although I suspect it has something to do with the negative feedback loop. Could you expand on this by chance? I do take micronized DHEA and pregnenolone as I do not take Human Chorionic Gonadotropin (HCG), but have heard mixed reports on if this is effective or not.
Megatron28
Moderator
Also, anyone know what labs should be run to see if anything is deficient (besides test and sperm count)?
Austinite
New member
TRT patients or anyone being considered for testosterone replacement therapy (TRT) should explore the following:
Total Testosterone
Bioavailable testosterone
Free Testosterone
SHBG
DHT (gel users especially)
Estradiol (sensitive assay for men)
LH
FSH
Prolactin
Cortisol
Thyroid Panel (full panel)
CBC
Comprehensive Metabolic Panel
Lipid Panel
Vitamin D
DHEA-s
gdevine
New member
Lh, or its active analog agent Human Chorionic Gonadotropin (HCG), activates the p450scc enzyme which is principally responsible for converting Cholesterol (CHOL) into Pregnenolone.
When we suppress HTPA via exogenous Testosterone LH production is seriously compromised. This is what many Doctor's don't consider when they suppress HTPA and don't supplement with HCG.
We need the conversion of CHOL into Pregnenolone as it's a pro-hormone and responsible for every other hormone in our bodies.
Megatron28
Moderator
^^^ That's my question. What's not happening? Besides natty test...
Is it just pregnenolone that one has to worry about? Is there a convenient lab test out there to check your pregnenolone levels?
gdevine
New member
^^^ That's my question. What's not happening? Besides natty test...
Is it just pregnenolone that one has to worry about? Is there a convenient lab test out there to check your pregnenolone levels?
The Preg labs that are out there are wildly inaccurate that's why most AA Doc's don't order.
Preg is found mostly in tissue not is serum is the biggest reason why.
DHEA-S is a better lab to measure as it's converted from Pregnenolone.
HCG without question acts on the brain. It's why many men claim a real sense of well being and satisfaction when they initially begin with HCG.
Some men, myself included, had a nice lift in libido as well so it's working on the neuro-receptors.
Dr. Crisler has a patient who went daily 150 iu Human Chorionic Gonadotropin (HCG) and only than did his libido kick in. Crisler recommends daily doses now of HCG
Read his paper on Human Chorionic Gonadotropin (HCG) it's one of the absolute best I've read on it: http://www.allthingsmale.com/word_docs/HCGupdate.doc
Supplementation with Pregnenolone is nothing like natural production and some men just don't metabolize supplements well.
We need the conversion of CHOL into Preg and only an LH analog like Human Chorionic Gonadotropin (HCG) will do that; we need to support all the other hormonal pathways as well.
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Megatron28
Moderator
Thanks. That helps!
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