IMO t3 is best run for 6 weeks with a 6 week cycle. I hate to diet longer than that. I believe ppl exaggerate how dangerous t3 is (just wait..they'll all come out) start at 25mcg and work your way up to 100mcg (upping the dose every few days). Pyramiding up is worthless IMO, pyramiding down is everything. The only reason I'm telling you to pyramid up is just to see if you have any type of negative reaction from it. Once at the 100mcg dose, I would stay there for a while, then slowly drop it down until you're off. Next cycle, dont bothering tapering up slowly...use 50mcg for 2 days then bump it to 100 (IMO again)