Basic Overview On Peptides

Yeah I've read similiar information. Dosing over the saturation point of 100mcg's will still yeild higher benefits, but will have diminishing returns. Last I read, I don't think there were any hard numbers on how much they diminish, but I'll look around and see if I can find the article.
 
With all this info, you would think the question of "igf pre or post" would be answered! Sounds like POST would be better to let MGF do its thing?

If so, why are so many doing igf pre wo?
 
shainesboostin said:
With all this info, you would think the question of "igf pre or post" would be answered! Sounds like POST would be better to let MGF do its thing?

If so, why are so many doing igf pre wo?
Click to expand...

That's cause they do not fully understand would be my guess. Or the like the crazy pump from it. That is fun I will admit But I have found that most that use it end up dosing it PWO once the understand every thing!
 
Hey guys lets try to keep this thread as clean as possible If you have some thing good to add reference material or such! Please do try to back any thing with or based on facts only here! If you have a questin or a debate please start a thread about it! We can address issues there this thread was stickied in hopes of maintaining a quick refference guide. To get you all started!

Thanks for the help.
Phat
 
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we need to make sure this sticky is all newer info/research.

too much, old, outdated peptide info out there now.

Before you guys post anything check the date of the post or article. if its B4, 2008-09 is most likely bad info.
 
gymrat827 said:
we need to make sure this sticky is all newer info/research.

too much, old, outdated peptide info out there now.

Before you guys post anything check the date of the post or article. if its B4, 2008-09 is most likely bad info.
Click to expand...

Very good point. I'm pretty up to date in this area because of my own research, but won't have time to read through all of this til the weekend so I'll contribute probably tomorrow evening.

Vibrant thanks for answering the call for info! We'll make sure newbs have one clear-cut place to start their adventure into the world of peptide use!
 
Extreme wealth of information here. The way pep science is constantly changing it is valuable to have updated info
 
Awesome info! I will be starting the MT2 after my hives from my recent tanning disaster! I will post photos week by week in my own thread for the MT2 and once I start my toning.... Gonna be a great summer. I think I am going to look and feel better than I ever have! Seriously can't wait and this forum is awesome motivation.
 
Hi Sassy, were you able to grab some M2 with that discount?
Sassytassie84 said:
Awesome info! I will be starting the MT2 after my hives from my recent tanning disaster! I will post photos week by week in my own thread for the MT2 and once I start my toning.... Gonna be a great summer. I think I am going to look and feel better than I ever have! Seriously can't wait and this forum is awesome motivation.
Click to expand...
 
I've researching Thymosin Beta-4(TB-500) and to me as an athlete the potential effects of it are very exciting. Some articles I found to give you guys an overview on it:


Thymosin Beta-4: Strong as a Horse?

by admin on December 6, 2011

Recently, a new doping drug has come on the scene for horse racing. Actually its been around for a while, but it seems to be catching on. So what does this have to do with humans? A lot.
Thymosin Beta-4 is a unique peptide that was first discovered in the thymus, a gland in the human body. Since that initial discovery, however, thymosins of all sorts have been found present in all different types of tissue throughout the body. One particular place we see Thymosin Beta-4 that is of interest to us, is muscle, both smooth (like heart muscle) and skeletal (our movement muscles). Thymosin Beta-4 is upregulated when damage occurs to muscle tissue. When trauma occurs, Thymosin beta-4 is released to increase the healing of that trauma. It also acts to prevent the formation of adhesions. This means less scar tissue, and hopefully, more flexibility.
TB500 is a synthetic version of Thymosin Beta-4 which does all the same wonderful things that its natural counterpart does. Some of the claims made by makers of TB500 include:


Endothelial (blood vessels) cell differentiation
Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues
Keratinocyte migration
Collagen deposition; and
Decreases inflammation.


In some instances, these are all good things. Increased blood flow, healthy vasculature, enhanced healing from skin abrasions (keratinocytes are part of the barrier in our skin that keeps bad stuff from just seeping in) collagen deposition (healthy joints, and of course decreased inflammation.
The last one in particular should make a lot of sense. Thymosin beta-4 is involved in regulating the immune system. Increasing levels of Thymosin Beta-4 through the use of TB500, would decrease our inflammatory response to injury, because the injury would be healing at a much faster rate. Inflammation is our bodys signal to repair. Once that repair is underway, inflammation goes down.
So we know what makers of it are touting for dogs and horses. Increased endurance, muscular strength, flexibility, less scarring, and decreased inflammation. But are there any benefits for humans? Some scientists think it may be able to help our hearts heal after a heart attack. I have seen one study show that Thymosin Beta-4 activates progenitor cells after a heart attack, essentially allowing the heart to heal itself. I have also read elsehwhere that this effect has not been reproduced during further testing.
What do i know about this new drug? Not much. I have actually experimented with 5 mg a week of this and have found it to be a great preworkout booster of sorts, but nothing dramatic as of yet. It has been said results come over time, so we shall see. I personally think the dosages being sold on the internet are much lower than we should take in order to see results, but that doesnt surprise me, as most online sources of research peptides tend to make sure the profit margin is well within their own favor. If supply becomes abundant and we see larger amounts surfacing for reasonable prices I may try and go for something more like 10 mg a day and see how that treats me.
In the meantime I keep stretching, and hoping this stuff will help increase my flexibility, which was the primary reason I showed interest in this. I am one giant muscle knot.

Source: http://www.metabolicalchemy.com/thymosin-beta-4/
 
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here's a press release from the pharmaceutical company that is conducting trials on TB-500:



Researchers Show TB4 Provides Both Neuroprotection and Neurorestoration after Traumatic Brain Injury
Researchers Show TB4 Provides Both Neuroprotection and Neurorestoration after Traumatic Brain Injury

February 15, 2012 Rockville, Md.
RegeneRx Biopharmaceuticals, Inc. (OTC Bulletin Board: RGRX) (the Company or RegeneRx) today announced that researchers have shown that Thymosin beta 4 (TB4) provides both neuroprotection and neurorestoration after traumatic brain injury (TBI), indicating that TB4 has promising therapeutic potential in patients with TBI.
The aims of the study were to test if TB4 treatment initiated 6 hours after traumatic brain injury in rats reduces brain damage and improves functional recovery. The rats were divided into two treatment groups and one placebo group. TB4 or placebo was systemically administered 6, 24, and 48 hours after injury. Compared with the placebo group, TB4 treatment initiated 6 hours post-injury statistically significant improvement of sensorimotor functional recovery and spatial learning, reduced cortical lesion volume and hippocampal cell loss, and enhanced cell proliferation and neurogenesis in the injured brain tissue. The high dose of TB4 showed better beneficial effects compared with the low dose treatment.
The research was conducted by Xiong Y, Zhang Y, Mahmood A, Meng Y, Zhang ZG, Morris DC, Chopp MJ in the Department of Neurosurgery at the Henry Ford Hospital System (HFHS) in Detroit, Michigan pursuant to a material transfer agreement between the hospital and RegeneRx Biopharmaceuticals, Inc. and published in Neurosurg., 2012 Feb 10. [Epub ahead of print].
"This preclinical study on the use of Thymosin beta 4 for the treatment of traumatic brain injury adds to the growing body of literature demonstrating the use of TB4 in neurological injury. The collective evidence of the neurorestorative properties of Tb4 in animal models of multiple sclerosis, stroke and traumatic brain injury are compelling and we look forward to evaluating this drug in clinical trials," stated Dr. Dan Morris, Senior Staff Physician, Department of Emergency Medicine at HFHS and one of the investigators in study.

About RegeneRx
RegeneRx is focused on the development of a novel therapeutic peptide, Thymosin beta 4, or Tb4, for tissue and organ protection, repair and regeneration. RegeneRx currently has three drug candidates in clinical development and has an extensive worldwide patent portfolio covering its products.

RGN-259 is a sterile, preservative-free topical eye drop for ophthalmic indications. Based on a recently completed Phase 2 clinical trial in patients with dry eye syndrome, RGN-259 was found to show statistically significant improvements in several signs and symptoms of dry eye, as well as positive trends in other outcome measures. We believe the positive results of this Phase 2 exploratory trial reflect RGN-259's reported mechanisms of action and provide RegeneRx with FDA-approvable endpoints to be targeted in future clinical trials.

RGN-352 is an injectable formulation to treat cardiovascular and central nervous system diseases, as well as other medical indications. RegeneRx is initially targeting RGN-352 for the treatment of patients who have suffered an acute myocardial infarction, or heart attack. Recent pre-clinical efficacy data suggests that RGN-352 may also benefit patients with multiple sclerosis, stroke and traumatic brain injury. RegeneRx has successfully completed a Phase 1 clinical trial with RGN-352 in which the drug candidate was found to be safe and well-tolerated. In 2010, RegeneRx received a $3 million, three-year development grant from the NIH to support the company's acute myocardial infarction program.

RGN-137, a topical gel formulation, is currently being evaluated by RegeneRx in a Phase 2 clinical trial for the treatment of the orphan skin disease epidermolysis bullosa. Other potential uses for RGN-137 include the treatment of chronic dermal wounds and reduction of scar tissue. RegeneRx previously received $675,000 in grants from the U.S. FDA to support this clinical trial.

Source: http://www.regenerx.com/wt/page/pr_1329315649
 
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ghrp-6 48 years of age

Hi im new to this site and this is my 1st post so please bare with me as the internet is not my best subject but trying my best. im after getting some onformation on using ghrp-6 for the 1st time at 48 years old and would like any help i can with this please.
 
vibrant said:
I've researching Thymosin Beta-4(TB-500) and to me as an athlete the potential effects of it are very exciting. Some articles I found to give you guys an overview on it:


Thymosin Beta-4: Strong as a Horse?

by admin on December 6, 2011

Recently, a new doping drug has come on the scene for horse racing. Actually its been around for a while, but it seems to be catching on. So what does this have to do with humans? A lot.
Thymosin Beta-4 is a unique peptide that was first discovered in the thymus, a gland in the human body. Since that initial discovery, however, thymosins of all sorts have been found present in all different types of tissue throughout the body. One particular place we see Thymosin Beta-4 that is of interest to us, is muscle, both smooth (like heart muscle) and skeletal (our movement muscles). Thymosin Beta-4 is upregulated when damage occurs to muscle tissue. When trauma occurs, Thymosin beta-4 is released to increase the healing of that trauma. It also acts to prevent the formation of adhesions. This means less scar tissue, and hopefully, more flexibility.
TB500 is a synthetic version of Thymosin Beta-4 which does all the same wonderful things that its natural counterpart does. Some of the claims made by makers of TB500 include:


Endothelial (blood vessels) cell differentiation
Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues
Keratinocyte migration
Collagen deposition; and
Decreases inflammation.


In some instances, these are all good things. Increased blood flow, healthy vasculature, enhanced healing from skin abrasions (keratinocytes are part of the barrier in our skin that keeps bad stuff from just seeping in) collagen deposition (healthy joints, and of course decreased inflammation.
The last one in particular should make a lot of sense. Thymosin beta-4 is involved in regulating the immune system. Increasing levels of Thymosin Beta-4 through the use of TB500, would decrease our inflammatory response to injury, because the injury would be healing at a much faster rate. Inflammation is our bodys signal to repair. Once that repair is underway, inflammation goes down.
So we know what makers of it are touting for dogs and horses. Increased endurance, muscular strength, flexibility, less scarring, and decreased inflammation. But are there any benefits for humans? Some scientists think it may be able to help our hearts heal after a heart attack. I have seen one study show that Thymosin Beta-4 activates progenitor cells after a heart attack, essentially allowing the heart to heal itself. I have also read elsehwhere that this effect has not been reproduced during further testing.
What do i know about this new drug? Not much. I have actually experimented with 5 mg a week of this and have found it to be a great preworkout booster of sorts, but nothing dramatic as of yet. It has been said results come over time, so we shall see. I personally think the dosages being sold on the internet are much lower than we should take in order to see results, but that doesnt surprise me, as most online sources of research peptides tend to make sure the profit margin is well within their own favor. If supply becomes abundant and we see larger amounts surfacing for reasonable prices I may try and go for something more like 10 mg a day and see how that treats me.
In the meantime I keep stretching, and hoping this stuff will help increase my flexibility, which was the primary reason I showed interest in this. I am one giant muscle knot.

Source: Thymosin Beta 4 for Muscle Strength, Mass and Endurance
Click to expand...


This looks great!
Been looking into this laitly.

Was in bad car accident a few years ago. got some buldging , pressing, loss of fluid- disk issues.

doing a IGF1LR3, GHRP-2, CJC-1295 + Osta, teste,maste studie now and seems to help a bit.

Wonder if in a couple years I should consider this.
 
HGH FRAGMENT 176-191



The HGH Fragment or HGH Frag is a modified form of amino acids 176-191 at the C-terminal region of growth hormone.

Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural hGH regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified hGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis and inhibits lipogenesis both in laboratory testing and in animals and humans. The HGH fragment does not appear to affect appetite.

In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the HGH frag released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), HGH fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted hGH effect.

The (HGH fragment 176-191) is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in a specific and physiological manner. To date studies suggest that (HGH fragment 176-191) has several beneficial features: it reduces abdominal fat (in particular visceral fat), without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile. These characteristics make it an ideal candidate for the treatment of excess abdominal fat, an important aspect of HIV-associated lipodystrophy.

At a dosage of 500mcg the (HGH fragment 176-191) was shown to increase lipolytic activity in adipose tissue. In other words this fragment potently burns body fat, especially stubborn adipose body fat, and it does so potently! Of significance, is that the fragment has no negative impact on insulin sensitivity, a stark contrast from its Human Growth Hormone counterpart.(Ng FM, Sun J,Sharma L, Libinaka R, Jiang WJ, and Gianello R 2000).

Not only does the (HGH fragment 176-191) not interfere with the bodys natural insulin regulation as Human Growth Hormone can, the (HGH fragment 176-191) does not result in cellular proliferation as Human Growth Hormone does. The fragment is similar to Human Growth Hormone, hence the shared amino acid sequence, however, the (HGH fragment 176-191) does not induce hyperglycaemia or reduce insulin secretion. The (HGH fragment 176-191) does not compete for the hGH receptor and nor does it induce cell proliferation, unlike Human Growth Hormone. (Wu Z, Ng FM. 1993).
 
And this is what Datbtrue has to say on it:

What I have gathered is you want to take this peptide on an empty stomach because HGH Frag 176 will mobilize fatty acids. IF you are trying to lose fat, you do not want insulin to be active while GH is active or else you won't lose much fat. In addition you want to make use of the newly mobilized fatty acids so cardio/activity is beneficial. HGH Frag 176-191 is the lipolytic/anti-lipogenic domain of intact hGH. the fragment with the amino acid sequence (176-191) is 56% more bioactive then the fragment with the amino acid sequence (177-191).


First you need to separate GH's lipolytic effect from its other effects.

When you do this you will see that lipolysis does not happen right away. It takes a specific amount of time before it starts.

Second there is a limit to how much lipolysis will be created with GH. That means a little is all you need and for that unit of time more will be no more effective.

Third there are other things that can be used in conjunction w/ GH to increase lipolysis beyond the GH effect threshold.

So that leaves you with timing. When lipolysis is occurring you want to be in fatloss mode. That means no surplus energy and it means doing things to oxidize the newly liberated fatty acids.

Often people are eating and have increased insulin levels by the time lipolysis is in full swing. That for the most part negates fatloss.

Then you need to understand how long lipolysis will last.

So all of this becomes part of a protocol. You don't just expect something to work w/o the proper environment. You can achieve the lipolysis threshold induced by GH w/ synthetic GH, GHRH/GHRP or GH Frag 176-191.

You should understand GH Frag 176-191 and use it properly. Proper use would be on fast day or days where you fast half the day.

A reconstituted vial degrades fairly quickly and so a whole vial should be used w/in a few days.

If you dose 1mg for the day the way to make it work is to dose 200mcgs every few hours five times during the entire day.

It is best if that day is fairly fasted and if you do eat a meal keep the blood glucose response to the meal contained and do not dose around that meal (or it will be wasted).

Note, that you will not waste away muscle in a fasted state and empty stomach cardio will not eat up muscle. The release of fatty acids or lipolysis is an anti-catabolic event. It is why GH in part is anti-catabolic.

Awaken in the morning and do empty stomach cardio after waiting for the GH induced lipolysis to be in full swing (from say previous GHRH/GHRP administration) and you will be able to effect fatloss and not worry about muscle loss.
 
There are many online educational resources about amino acids and peptides. We will find them useful as a researcher or as an educator. There are many international peptide societies. Some of the important among them those which are providing knowledge about these Peptides are Amino acid basics, Amino review basics, Bio-active peptide database and many more.


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