Best AI to run during a test cycle


Cycle, test, HGH
I plan to run a test and Anavar (var) cycle soon, I want to run an Aromatase inhibitor (AI) throughout such as Arimidex or Aromasin both look good...I've read up on Letrozole but it looks like it's got to many sides.

Which would be better in real life, both look good on paper but what about real life sides..should I expect any ?

On a side note I'll be running HCG throughout and finish the Aromatase inhibitor (AI) before starting post cycle therapy (pct) of Nolva

I want to avoid bloat, gyno and high colesterol also worried about estrogen bounce after finishing the AI.

Appreciate any advice ?
After having some experience with adex and aromasin i'd say to run adex and then switch over to aromasin towards the end of you cycle.
Arimidex is not more potent than Aromasin. It's very weak in comparison. AIFM which is made with one of the original AI's that later became the basis for Aromasin is also much stronger. The best for potency AND price is AIFM. Arimidex also affects cholesterol levels and Aromasin and AIFM do not.
Isn't it bad to suppress estrogen to far, I don't want to drop levels to zero so would you really want an Aromatase inhibitor (AI) that is very powerful, surely an average Aromatase inhibitor (AI) would be the best, then the risk of to lower levels could be avoided ?
AI's don't suppress E levels that low in men. The average suppression in men is about 60% so there is plenty there left over.
Thanks Ulter, been reading up on it and it looks real good. :D Since AIFM is a topical is there any benefit in applying this straight to the chest region ?
Not really. And you want to put it on a different place every day so you don't get any build up that can lead to a rash in some people.
Thanks ulter , due to the slight chance of hit and miss effect with topical applications i.e it isn't absorbed properly one day, arn't people slightly in favour of an oral such as aromisin, at least you know 100% it has been ingested correctly ? sorry for all the questions just want to be sure :)
there is no hit and miss with AIFM. though when it comes to bioavailability of orals, they are going to vary from day to day as well (something that no one ever seems to bring up), some will vary slightly others by a significant amount. What you have eaten, if you take with or without food, affects of foods, supplements and drugs on enzymes like cyp3a4.

taking grapefruit juice prior will increase plasma uptake of aromasin (decreases gut cyp3a4 levels).
agree that letro and nolva should be kept on hand.

IMHO you should always have 2 AI's and both clomid and nolva on hand.

however nolva should not be used with or after progestins, this can actually cause worsening of symptoms. IMHO nolva use during post cycle therapy (pct) after progestins is one the the most common causes of post cycle gyno.

as a further note- generally reccomend clomid (no frontload) over nolva for PCT. its much better established in restoration of the HPGA.
Nolva can decrease the effects of a-dex if they are combined but not if combined with aromasin and aromasin is a third generation Aromatase inhibitor (AI) the best IMO ,read the post cycle therapy (pct) protocoll by anthony roberts he writes alot of interessting things abóut aromasin:

Aromasin (Exemestane) is one of those weird compounds that nobody really knows what to do with. What we generally hear about it makes it very uninteresting…It’s a third generation Aromatase Inhibitor (AI) just like Arimidex (Anastrozole) and Femera (Letrozole). Both of those two drugs are very efficient at stopping the conversion of androgens into estrogen, and since we have them, why bother with Aromasin? It’s a little harder to get than the other two commonly used aromatase inhibitors, because it’s not in high demand, and there’s never been a readily apparent advantage to using it. And I mean…lets face it: It’s awkward-sounding. Aromasin doesn’t have much of a ring to it, and exemestane is even worse. Arimidex has a bunch of cool abbreviations ("A-dex" or just ‘dex) and even Letrozole is just "Letro" to most people. Where’s the cool nickname for

Aromasin/exemestane? A-Sin? E-Stane? It just doesn’t work. It’s the black sheep of AIs. And why do we even need it when we have Letrozole, which is by far the most efficient Aromatase inhibitor (AI) for stopping aromatization (the process by which your body converts testosterone into estrogen)? Letro can reduce estrogen levels by 98% or greater; clinically a dose as low as 100mcgs has been shown to provide maximum aromatase inhibition (2)!

So why would we need any other AIs? Well, first of all, estrogen is necessary for healthy joints (3) as well as a healthy immune system (4). So getting rid of 98% of the estrogen in your body for an extended period of time may not be the best of ideas. This may be useful on an extreme cutting cycle, leading up to a bodybuilding contest, or if you are particularly prone to gyno, but certainly can’t be used safely for extended periods of time without compromising your joints and immune system.

That leaves us with Arimidex, which isn’t as potent as Letrozole, but at .5mgs/day will still get rid of around half (50%) of the estrogen in your body. Problem solved, right? Use Arimidex on your typical cycles, and if you are very prone to gyno or are getting ready for a contest, use Letro.

But what about Post Cycle Therapy (PCT)?

I think at this point most people are sold on the use of Nolvadex (Tamoxifen Citrate) instead of Clomid for post cycle therapy (PCT), since both compete estrogen at the receptor site, both increase serum test levels, and both drugs may also alter blood lipid profiles favorably (6). But since 20mgs of Tamoxifen is equal to 150mgs of clomid for purposes of testosterone elevation, FSH and LH, but Tamoxifen doesn’t decrease the LH response to LHRH (6) I think most people agree to Nolvadex’s superiority for PCT.

Aromasin with Nolvadex

I’ve always been in favor of using Nolvadex during PCT, along with an Aromatase inhibitor (AI), because reducing estrogen levels has been positively correlated with an increase in testosterone (7) so in my mind, it’s be beneficial to increase testosterone by as many mechanisms as possible while trying to recover your endogenous testosterone levels after a cycle. SO which Aromatase inhibitor (AI) do we use? Letro or A-dex? Well, why don’t we just keep using whichever one we used during the cycle, and add in some Nolvadex? Unfortunately, Nolvadex will significantly reduce the blood plasma levels of both Letrozole as well as Arimidex (8). So if we choose to use one of them with our Nolvadex on PCT, we’re throwing away a bit of money as the Nolvadex will be reducing their effectiveness.

This, of course, is where Aromasin comes in, at 20-25mgs/day.

Aromasin, at that dose, will raise your testosterone levels by about 60%, and also help out your free to bound testosterone ratio by lowering levels of Sex Hormone Binding Globulin (SHBG), by about 20% (12)…SHBG is that nasty enzyme that binds to testosterone and renders it useless for building muscle. But what about using it along with Nolvadex for post cycle therapy (pct)?

Difference Between Type-I and Type-II Aromatase Inhibitors

To understand why Aromasin may be useful in conjunction with Nolvadex while both Letro and A-dex suffer reduced effectiveness, we’ll need to first understand the differences between a Type-I and Type-II Aromatase Inhibitor. Type I inhibitors (like Aromasin) are actually steroidal compounds, while type II inhibitors (like Letro and A-dex) are non-steroidal drugs. Hence, androgenic side effects are very possible with Type-I AIs, and they should probably be avoided by women. Of course, there are some similarities between the two types of AIs…both type I & type II AIs mimic normal substrates (essentially androgens), allowing them to compete with the substrate for access to the binding site on the aromatase enzyme. After this binding, the next step is where things differ greatly for the two different types of AI’s. In the case of a type-I Aromatase inhibitor (AI), the noncompetitive inhibitor will bind, and the enzyme initiates a sequence of hydroxylation; this hydroxylation produces an unbreakable covalent bond between the inhibitor and the enzyme protein. Now, enzyme activity is permanently blocked; even if all unattached inhibitor is removed. Aromatase enzyme activity can only be restored by new enzyme synthesis. Now, on the other hand, competitive inhibitors, called type II AI’s, reversibly bind to the active enzyme site, and one of two things can happen: 1.) either no enzyme activity is triggered or 2.) the enzyme is somehow triggered without effect. The type II inhibitor can now actually disassociate from the binding site, eventually allowing renewed competition between the inhibitor and the substrate for binding to the site. This means that the effectiveness of competitive aromatase inhibitors depends on the relative concentrations and affinities of both the inhibitor and the substrate, while this is not so for noncompetitive inhibitors. Aromasin is a type-I inhibitor, meaning that once it has done its job, and deactivated the aromatase enzyme, we don’t need it anymore. Letrozole and Arimidex actually need to remain present to continue their effects. This is possibly why Nolvadex does not alter the pharmacokinetics of Aromasin (11).


Before we close the book on Aromasin, it’s worth noting that you can (and should) still use one of the non-steroidal AIs during your cycle to reduce estrogen, if necessary. When you are ready for PCT, you can then switch over to Aromasin and still experience the full effects of an Aromatase inhibitor (AI), since there is no cross-over tolerance experienced between steroidal and non-steroidal AIs (9). Since Aromasin is about 65% efficient at suppressing estrogen (10), it’s certainly a very powerful agent, especially considering you won’t experience reduced effectiveness because of your concurrent use of Nolvadex or from any sort of tolerance developed by using other AIs on your cycle(9). There is also a decent amount of preclinical data suggesting that Aromasin has a beneficial effect on bone mineral metabolism that is not seen with non-steroidal agents, and it may also have beneficial effects on lipid metabolism that are not found in the non-steroidal Letro and A-dex (9).

Finally, as we’re going to be using Nolvadex for post cycle therapy (pct) anyway, and we ought to be using an Aromatase inhibitor (AI) with it for maximum recovery…I think Aromasin- considering it’s compatibility with Nolvadex and beneficial effects on bone mineral content and lipid profile, has finally stopped being the black sheep of AIs and found a home in our cycles.


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Thx everyone :)

Macro and Ulter how involved are you with AIFM, are you just an end user like myself ?
designed the formulation...have used AIFM off and on for the last 13 months. straight use for the first 7 or 8 months. You will have to ask ulter about his usage, though believe that he has used it fairly consistently since before it was released. as far as his involvement he owns the AFSTORE which sells AIFM, among other things.
"Before we close the book on Aromasin, it’s worth noting that you can (and should) still use one of the non-steroidal AIs during your cycle to reduce estrogen, if necessary. When you are ready for PCT, you can then switch over to Aromasin and still experience the full effects of an Aromatase inhibitor (AI), since there is no cross-over tolerance experienced between steroidal and non-steroidal AIs (9). "

Thanks bmass. This proves my recomendation to be a good one.