burning off the ester off the testosterone cyp ester

[halfwit]

Okay, for starters: I found something out I didn't know. Conversion of testosterone to DHEA and estrogen is responsible by the cytochrome process! In fact aromatase IS a CYP enzyme known as CYP19A1. Source

I have to agree with Dre in that the bloat and other sides like that which used to be attributed to ester are usually based on poor estrogen management. Just like deca dick and other nasties that we all hear about when starting in this game, it's a lack of an Aromatase inhibitor (AI) or dopamine agonist that contributes to these and the spread of misinformation. This is easily proved by seeing how successful 19-nor runs or long ester cycles have fantastic gains with minimal sides and a panel showing a good optimal E2 value on mid-cycle bloods.

Now to the function and role of CYP3A4; unfortunately I am finding the need to quote wikipedia for this part:

Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5***945;-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-alpha reductase. DHT binds to the same androgen receptor even more strongly than testosterone, so that its androgenic potency is about 5 times that of T.[126] The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

Source
That partly explains how the hormones are delivered to receptors and the role of the enzymes, but doesn't truly explain how this conversion to enable cytoplasmic transfer occurs. To try to find how this occurs, I had to do a bit more digging, and found a pretty wordy explanation, but it is a little hard to follow:

Molecular Function: quinine 3-monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; albendazole monooxygenase activity; taurochenodeoxycholate 6alpha-hydroxylase activity; oxidoreductase activity; oxygen binding; steroid binding; testosterone 6-beta-hydroxylase activity; vitamin D3 25-hydroxylase activity; enzyme binding; electron carrier activity; iron ion binding; heme binding; steroid hydroxylase activity; monooxygenase activity.

Source

I realize that this isn't a clear-cut explanation, but apparently this is an area of human biology that still does elude modern science. I know it doesn't answer your question regarding possible ester issues, but if there was one; I'd wager that it is largely to do with not only a potential esterase problem, but possibly a cytochrome problem - causing you to excrete (hyper-excretion) the hormone before it is put to use. Here is some good reading on esterase for some leisurely reading in case you're interested.

The only thing that bothers me is if you had a total test blood panel run and it showed you at supraphysiological levels of testosterone, you shouldn't have a problem at all as that means you've cleaved the ester, and it hasn't been excreted entirely. I'd honestly get a look (as Megatron mentioned) your SHBG and Free Testosterone to get a bigger picture here.

Hope this helps.

 

[p91swat]

Yeah but i dont understand testosterone does not need to be activated by anything. what do the cyp enzymes do to testosterone that it makes it usable for the body change it chemically? i understand it converts some to dht and estrogen but testosterone is testosterone ready to use by the body. if i was injecting gram after gram then i should feel atleast something no matter i fast i excrete it. i think not only my body cant hydrolyze cyp ester it just plain rejects it/anti bodies.

this may also explain why test has to kick in and you dont feel it in the first week even if you injected the whole 20ml bottle of test. your body has to accept it or somethin.


some so simple yet so complicated lol

 

[halfwit]

Yeah but i dont understand testosterone does not need to be activated by anything. what do the cyp enzymes do to testosterone that it makes it usable for the body change it chemically? i understand it converts some to dht and estrogen but testosterone is testosterone ready to use by the body. if i was injecting gram after gram then i should feel atleast something no matter i fast i excrete it. i think not only my body cant hydrolyze cyp ester it just plain rejects it/anti bodies.

this may also explain why test has to kick in and you dont feel it in the first week even if you injected the whole 20ml bottle of test. your body has to accept it or somethin.


some so simple yet so complicated lol

Yeah, I'd have to do some more serious homework on how the hormone itself is oxidized for use - but I can tell you that the reason why it takes several weeks to "feel" (you really don't feel test kicking in aside from raging boners and possibly more aggression.) is it has to build up to serum saturation levels. This is of course based on a longer ester such as enanthate or cypionate. TNE kicks in immediately and DOES have a pretty damn good response as a pre-workout due to a very short active half-life.

I still think you should try enanthate/prop and see how it goes. Or you could try what bmays posted, which looks like a lot of work to me!

 

[Kazmir]

The reason you do not "feel it right away" is due to the ester which controls the release rate of the test hormone. Use test suspension aka TNE and you will feel it an hour or 2 later. This is why your reasoning makes no sense, the ester is attached to the hormone control the release rate of the hormone, it does not get rejected by the body it gets absorbed whether your body wants it or not. Think of it this way, take an advil liquid gel for example, the advil contained inside the gel cap is your test, the gel cap is your ester. Your stomach breaks down the gel cap and the advil is relased into your body.. Same exact thing with test and esters

 

[2rude4u]

the fuck dont you understand about that. people were going to get biased against certain esters. especially new users. but that was not my intention it was just for people who dont react well to cyp.

What the fuck I don't understand is ALL OF IT JUST LIKE THE REST OF YOUR MORONIC POSTS!!!

Nobody is losing cyp sales because you claim it doesn't work on you. You have a very overrated opionion of yourself and contrary to what you might believe nobody gives a shit what you post regarding cyp esters.

 

[Kazmir]

Its more of a I know my thinking is right and I will keep trying until someone sees it my way... You have been given your answer to your question numerous times. The ester is bound to the test molecule in the powder form before it is processed through a carrier oil for injection, taking a solution of test cyp from the pharmacy and removing the ester is not something you can do yourself as it would require extracting the hormones from the oil and returning it to powder form (back to its original stated, then processed through a chemical reaction to unbind the test from the cyp ester.. Not gonna happen in your home and would cost you an arm and a leg to have done in a lab... No one is going to agree with you about the issue your having being the cyp ester itself, your body rejecting said test cyp hormone or the carrier oil would result in an abcess or being extremely sick after injecting the test cyp.. You only option is to switch to test enanthate, test prop, test acetate, test suspension or test undecanoate, omnadrens, sustanon, etc..

Secondly you have zero blood work to substantiate any of the claims you are stating to prove that the test cyp is not working, you have not mentioned trying any other form to compare it to, nor have you given any sane reasoning behind thinking what you believe is the issue. You state you get your gear from the pharmacy but cypionate is the only thing you can get which is surprising as most will also have enanthate and if you are outside of Canada or the US most will have sustanon as well. Try a respectable lab then and get enanthate or another form of test.
Your beating a dead horse in this post and people are gonna get frustrated trying to educate you or lead you in the right direction..