ready2explode said:There is no such things as "progesterone gyno."
ready2explode said:Re-read this. After that, go find me a study mentioning gyno caused solely by progesterone. You're not going to find one because there isnt one...but you can try if ya like.
He goes on to explain:Originally posted by hhajdo
It looks like it will take a long time for that myth to die...
Int J Androl 1984 Feb;7(1):53-60 Related Articles, Links
Prolactin secretion in the human male is increased by endogenous oestrogens and decreased by exogenous/endogenous androgens.
Gooren LJ, van der Veen EA, van Kessel H, Harmsen-Louman W, Wiegel AR.
There is evidence that prolactin may be involved in testicular steroidogenesis, and we have therefore investigated whether there is feedback regulation of androgens/oestrogens on prolactin secretion in the human male. To assess this we have measured basal and TRH-stimulated prolactin levels in: Six eugonadal men before and after 2 weeks' administration of the aromatase inhibitor delta'-testolactone, which led to a fall in oestradiol levels with unchanged levels of testosterone. In these patients, prolactin levels decreased. Six eugonadal subjects before and after 6 weeks' administration of dihydrotestosterone undecanoate. In these subjects, prolactin levels decreased. Six agonadal subjects, tested after 12 weeks' treatment with dihydrotestosterone undecanoate and compared to: Six agonadal subjects who received no sex steroid treatment. Again, it was found that dihydrotestosterone treatment decreased prolactin levels in patients from Group C. Six eugonadal subjects were also studied before and after 6 weeks' administration of the androgen receptor antagonist, spironolactone, and this treatment increased Prl secretion. It is concluded that in the human male, endogenous oestrogens increase prolactin secretion whilst exogenous/endogenous androgens decrease prolactin secretion
Originally posted by hhajdo
That bromo+fina doesn't make much sense since PRL secretion in males is generally decreased by androgens.
If PRL is increased on a cycle which contains AS that aromatize, it could be controlled by using SERMs or aromatase inhibitors.
Originally posted by jgunz
...progsterone is merely a part of a coordinated effort of hormones that MUST BE PRESENT in order for gyno to occur. Prolactin cannot be simply elevated and poof,here comes gyno. Estrogen must be present, which is the pathway through which most documented gyno occurs.
Originally posted by hhajdo
I've never heard of anyone having problems with lactation on tren only cycle.
Studies I've seen indicate that both progestins & androgens lower PRL.
I consider PRL increase on a tren cycle very unlikely, it's hard to make a conclusion when people run several other drugs along with it.
Tamoxifen still seems to be the best solution if you're worried about gyno, since it will block estrogen and reduce IGF-1 at the same time.
It can also be effectivly used during a cycle which contains aromatizable AS to prevent PRL increase induced by elevated estrogen.
Originally posted by jgunz
Please... The onlyproven treatment for gyno has been estrogen antagonist/agonists like Nolvadex, clomid, and similar drugs. Nolvadex by far has the most science behind it. Herbal remedies and bromocriptine have never been proven.
Originally posted by nandi12
If you have gyno, take Nolvadex. If you are worried about getting gyno, take Nolvadex
Originally posted by macro
use of tamox is fine, but some (likely many) will respond better to the addition of a dopaminergic..
actually the use of an aromatase inhbitor, a SERM and prolactin inhbition in varying degrees is likely the "best" approach...