How much does iron intake affect the rise in hct on trt? Before starting T I was on Clomid therapy and on my yearly physical my hct was 48. I by chance donated blood and a week later I had bloods taken by my new trt doc which showed hct at 43. I started t at 100mg wk with 250 iux2 of hcg with arimidex. Four weeks later my hct was back to 50. I start feeling effect of high hct about every four weeks. I have been doing donations every six weeks between two banks. I just recently found my well water had a pretty high iron content. Could that excess iron intake have contributed to a faster rise in hct? I just had bloods done the other day for my appt next week so I will see where I am now. I donated 6 weeks ago but feel like I need to again. I am also switching to 2x50mg per wk injections to see if the initial spike was contributing to the fast raise in hct. My trough five days after injecting was still mid 800s. I'm really hoping that the iron was contributing the fast raise in hct. It is causing me anxiety worrying where my hct is and I really don't want to stress over it because I never had issues on Clomid but switched to t as i felt it was better long term.