ripped1979
New member
Is this true, wouldn't the grapefruit juice destroy the oxandrolone..? I know that sounds a bit stupid, but grapefruit juice is highly concentrated and acidic..?
Grapefruit juice with oxandrolone helps absorbtion?
- Thread starter ripped1979
- Start date
It certainly won't destroy the ox. Grapefruit juice contains an enzyme that increases the absorbtion of a lot of drugs. I believe it has been settled that ox is one of them.
I have actually seen some warnings that gf juice should be avoided when taking certain drugs, so as not to "overdose". I can't imagine overdosing on ox, I'd have to be made of $$$$$$.
I have actually seen some warnings that gf juice should be avoided when taking certain drugs, so as not to "overdose". I can't imagine overdosing on ox, I'd have to be made of $$$$$$.
ripped1979
New member
lololol, Oh yes at the price I'm paying guys it would
ripped1979
New member
be honest which is youyr favorite anavar to take?
ripped1979
New member
Definitely agree! But I just finished week one with still no strength gains yet. Hopefully week 2 will bring in some strength.
WARBIRDWS6
New member
sucks to add the cals though when cutting on anavar. i know, it isn't that much.....but every bit counts. 
Drveejay11
Community Veteran
http://boards.****************/forum/showthread.php?s=&threadid=155276&highlight=oral+users
Check this out:
Punchier Drugs--With Grapefruit Juice
A glass of grapefruit juice not only helps the pill go down, it also makes it more potent. Now, a study in the current Journal of Clinical Investigation has revealed why: A substance in the juice fights a drug-degrading enzyme in the intestine. The insight could be a first step toward increasing the effectiveness of some oral drugs.
About 3 years ago, researchers noted that grapefruit juice helps the body absorb many types of drugs, including sedatives, hormones, and protease inhibitors. A group of doctors from the University of Michigan and the London Health Sciences Centre, in London, Ontario, set out to investigate. They focused on an enzyme in the liver and intestine, called CYP3A4, that usually breaks down toxins from spoiled food. "It's [also] the most prolific of the drug-degrading enzymes," says Paul Watkins, a member of the Michigan team. In fact, it contributes to the breakdown of about half of all known human drugs.
Watkins and his colleagues gave felodipine, a calcium channel blocker used to control high blood pressure, to 10 healthy men, both with and without grapefruit juice. The grapefruit juice increased blood concentrations of felodipine more than fourfold. The team also measured the concentrations of CYP3A4 levels in the intestine and found that they fell by 62%. Something in grapefruit juice appears to be blocking the action of CYP3A4. But the concentration of CYP3A4 in the liver was unchanged--suggesting that the juice does not affect the rate at which the drug is metabolized once it enters the bloodstream.
If the active ingredient of grapefruit juice can be identified and isolated, drugs might be made more effective--and less expensive per useful dose. Adding grapefruit's CYP3A4 blocker to a pill could also assure a set dosage, an advantage, because people naturally vary 10-fold in how much of a drug they absorb. "It will make a lot of difference in the way people take drugs," predicts Raymond Woosley, a pharmacologist at Georgetown University Medical Center
________________________________________________________
More on this..... (post #2)
GRAPEFRUIT JUICE AND DRUGS
HOW DOES GRAPEFRUIT JUICE AFFECT THE DRUGS I AM TAKING?
Grapefruit juice blocks cytochrome P-450 3A4 and Ia2 (CYP3A4 and CYP1A2) enzymes in your intestinal wall. Common to all living organisms, the body has evolved the cytochrome P-450 system, a superfamily of enzymes responsible for removing drugs and toxins from the body. The cytochrome P-450 3A4 subfamily, located predominantly in the liver and intestinal tract, is one of the most common enzyme systems for metabolizing drugs. Most drugs are lipid-soluble or"fat-loving", so that they are readily absorbed in your bloodstream. To eliminate these drugs, however, in the cytochrome P450 system either breaks them down in the gut or changes them in to a more water-soluble or "water-loving" version in the liver. The kidney can then eliminate them in the urine. Thus, the liver,gut, and kidney work together to prevent excessive amounts of drug and/or toxins from getting in to your bloodstream. Grapefruit juice blocks the cytochrome P450 3A4 enzyme systems in your gut. By inhibiting this defence mechanism, grapefruit juice may increase the blood levels of some drugs. Therefore, you may experience adverse effects from the drugs you are taking when taken with grapefruit juice.
WHICH SUBSTANCE IN THE GRAPEFRUIT JUICE IS RESPONSIBLE FOR THESE INTERACTIONS WITH DRUGS?
The precise chemical nature of the substance in the grapefruit juice that inhibits gut wall CTP 3A4 enzymes is unknown. It has been suggested that flavanoids, coumarin, or psoralen derivatives in the grapefruit juice could be the inhibitors. The amount of inhibiting substance in grapefruit juice may vary by brand, concentrations and storage conditions.
I DRINK ONE GLASS OF REGULAR GRAPEFRUIT JUICE WITH BREAKFAST IN THE MORNING, WILL THIS AFFECT THE DRUGS I AM TAKING?
Yes. Regular grapefruit juice is prepared by diluting frozen grapefruit juice with normal amount of water. Double-strength grapefruit juice is prepared by diluting frozen grapefruit juice with half the normal amount of water. One glass of regular grapefruit juice is enough to significantly raise the blood levels of the number of drugs.
FOR HOW LONG DOES THE GRAPEFRUIT JUICE INHIBIT CYP 3A4?
The inhibitory effect of grapefruit juice on CYP 3A4 can last for several hours. A recent study found increased blood levels of calcium-channel blocker felodipine (Plendil) even when the drug was given 24 hours after drinking grapefruit juice.
I TAKE AN EXTENDED RELEASE PRODUCT, IS THIS ALSO AFFECTED BY GRAPEFRUIT JUICE?
Yes. Grapefruit juice increases the blood levels of extended release preparations. Recent studies have shown increased blood levels of extended release felodipine,extended release nifedipine (Adalat, Procardia) when taken with grapefruit juice.
WHICH DRUGS ARE AFFECTED BY GRAPEFRUIT JUICE AND WHAT HAPPENS WHEN THEIR BLOOD LEVELS INCREASE?
CYP 3A4 is involved in the metabolism of many medications. When CYP 3A4 is inhibited by grapefruit juice, the blood levels of many medications may rise. Examples of drugs reported to interact are listed in the table below. Since many more drugs are likely to interact, it is important to ask your doctor or pharmacist if you drink grapefruit juice and are taking any medications.
________________________________________________________
Hey bro's....GREAT NEWS for the time-being. I found out that a supplement called "bioperine" increases oral absorption of "drugs/other supplements" when taken at the same time!!! Bioperine comes from "black pepper extract".
From Beyond-A-Century: BIOPERINE(r) is a 95% piperine extract from the black pepper plant that is thermogenic and enhances the absorption of nutrients from the gastrointestinal tract. In 5mg doses, Bioperine enhanced the blood levels and bioavailability of a wide range of nutrients, both fat & water soluble. Powder should be mixed with other nutrients. 1 gram, $2.00. Code 866.0
--------------------------------------------------------------------------------
BIOPERINE(r) 10mg tablets, 120 tabs, $7.20 Code 866.5
CHeap-as-hell !!! Until I find out more about "grapefruit" extract, this seems like a great find! Hell, all the cash we spend on orals (especially anavar/primobolan)...how could you NOT want to use this in conjunction???
http://www.beyond-a-century.com/
________________________________________________________
Check this out:
Punchier Drugs--With Grapefruit Juice
A glass of grapefruit juice not only helps the pill go down, it also makes it more potent. Now, a study in the current Journal of Clinical Investigation has revealed why: A substance in the juice fights a drug-degrading enzyme in the intestine. The insight could be a first step toward increasing the effectiveness of some oral drugs.
About 3 years ago, researchers noted that grapefruit juice helps the body absorb many types of drugs, including sedatives, hormones, and protease inhibitors. A group of doctors from the University of Michigan and the London Health Sciences Centre, in London, Ontario, set out to investigate. They focused on an enzyme in the liver and intestine, called CYP3A4, that usually breaks down toxins from spoiled food. "It's [also] the most prolific of the drug-degrading enzymes," says Paul Watkins, a member of the Michigan team. In fact, it contributes to the breakdown of about half of all known human drugs.
Watkins and his colleagues gave felodipine, a calcium channel blocker used to control high blood pressure, to 10 healthy men, both with and without grapefruit juice. The grapefruit juice increased blood concentrations of felodipine more than fourfold. The team also measured the concentrations of CYP3A4 levels in the intestine and found that they fell by 62%. Something in grapefruit juice appears to be blocking the action of CYP3A4. But the concentration of CYP3A4 in the liver was unchanged--suggesting that the juice does not affect the rate at which the drug is metabolized once it enters the bloodstream.
If the active ingredient of grapefruit juice can be identified and isolated, drugs might be made more effective--and less expensive per useful dose. Adding grapefruit's CYP3A4 blocker to a pill could also assure a set dosage, an advantage, because people naturally vary 10-fold in how much of a drug they absorb. "It will make a lot of difference in the way people take drugs," predicts Raymond Woosley, a pharmacologist at Georgetown University Medical Center
________________________________________________________
More on this..... (post #2)
GRAPEFRUIT JUICE AND DRUGS
HOW DOES GRAPEFRUIT JUICE AFFECT THE DRUGS I AM TAKING?
Grapefruit juice blocks cytochrome P-450 3A4 and Ia2 (CYP3A4 and CYP1A2) enzymes in your intestinal wall. Common to all living organisms, the body has evolved the cytochrome P-450 system, a superfamily of enzymes responsible for removing drugs and toxins from the body. The cytochrome P-450 3A4 subfamily, located predominantly in the liver and intestinal tract, is one of the most common enzyme systems for metabolizing drugs. Most drugs are lipid-soluble or"fat-loving", so that they are readily absorbed in your bloodstream. To eliminate these drugs, however, in the cytochrome P450 system either breaks them down in the gut or changes them in to a more water-soluble or "water-loving" version in the liver. The kidney can then eliminate them in the urine. Thus, the liver,gut, and kidney work together to prevent excessive amounts of drug and/or toxins from getting in to your bloodstream. Grapefruit juice blocks the cytochrome P450 3A4 enzyme systems in your gut. By inhibiting this defence mechanism, grapefruit juice may increase the blood levels of some drugs. Therefore, you may experience adverse effects from the drugs you are taking when taken with grapefruit juice.
WHICH SUBSTANCE IN THE GRAPEFRUIT JUICE IS RESPONSIBLE FOR THESE INTERACTIONS WITH DRUGS?
The precise chemical nature of the substance in the grapefruit juice that inhibits gut wall CTP 3A4 enzymes is unknown. It has been suggested that flavanoids, coumarin, or psoralen derivatives in the grapefruit juice could be the inhibitors. The amount of inhibiting substance in grapefruit juice may vary by brand, concentrations and storage conditions.
I DRINK ONE GLASS OF REGULAR GRAPEFRUIT JUICE WITH BREAKFAST IN THE MORNING, WILL THIS AFFECT THE DRUGS I AM TAKING?
Yes. Regular grapefruit juice is prepared by diluting frozen grapefruit juice with normal amount of water. Double-strength grapefruit juice is prepared by diluting frozen grapefruit juice with half the normal amount of water. One glass of regular grapefruit juice is enough to significantly raise the blood levels of the number of drugs.
FOR HOW LONG DOES THE GRAPEFRUIT JUICE INHIBIT CYP 3A4?
The inhibitory effect of grapefruit juice on CYP 3A4 can last for several hours. A recent study found increased blood levels of calcium-channel blocker felodipine (Plendil) even when the drug was given 24 hours after drinking grapefruit juice.
I TAKE AN EXTENDED RELEASE PRODUCT, IS THIS ALSO AFFECTED BY GRAPEFRUIT JUICE?
Yes. Grapefruit juice increases the blood levels of extended release preparations. Recent studies have shown increased blood levels of extended release felodipine,extended release nifedipine (Adalat, Procardia) when taken with grapefruit juice.
WHICH DRUGS ARE AFFECTED BY GRAPEFRUIT JUICE AND WHAT HAPPENS WHEN THEIR BLOOD LEVELS INCREASE?
CYP 3A4 is involved in the metabolism of many medications. When CYP 3A4 is inhibited by grapefruit juice, the blood levels of many medications may rise. Examples of drugs reported to interact are listed in the table below. Since many more drugs are likely to interact, it is important to ask your doctor or pharmacist if you drink grapefruit juice and are taking any medications.
________________________________________________________
Hey bro's....GREAT NEWS for the time-being. I found out that a supplement called "bioperine" increases oral absorption of "drugs/other supplements" when taken at the same time!!! Bioperine comes from "black pepper extract".
From Beyond-A-Century: BIOPERINE(r) is a 95% piperine extract from the black pepper plant that is thermogenic and enhances the absorption of nutrients from the gastrointestinal tract. In 5mg doses, Bioperine enhanced the blood levels and bioavailability of a wide range of nutrients, both fat & water soluble. Powder should be mixed with other nutrients. 1 gram, $2.00. Code 866.0
--------------------------------------------------------------------------------
BIOPERINE(r) 10mg tablets, 120 tabs, $7.20 Code 866.5
CHeap-as-hell !!! Until I find out more about "grapefruit" extract, this seems like a great find! Hell, all the cash we spend on orals (especially anavar/primobolan)...how could you NOT want to use this in conjunction???
http://www.beyond-a-century.com/
________________________________________________________
ripped1979
New member
Excellent feedback, thank you Drveejay11! Basically its also good to take the anavar on an empty stomach with grapefruit juice for better absorbtion
Drveejay11
Community Veteran
yup 
Drveejay11
Community Veteran
Narginin Tabs and/or Black Pepper extract (Bioperine)
Grapefruit Pills
Past discussions on elite seemed to conclude that WHOLE grapefruit juice or extract was required, not just the SEED extract or narrig-something-or-another .
anyways, here is the one WHOLE grapefruitextract PILL (no calories!) I was abvle to find.
here is the manufacturers site (you can order here):
http://www.getyourgrapefruit.com/
here is the press release on the product- says its made from the inside, the skin, everything.
http://www.prnewswire.com/Tbutton/B...fruitoffer.html
Past discussions on elite seemed to conclude that WHOLE grapefruit juice or extract was required, not just the SEED extract or narrig-something-or-another
.anyways, here is the one WHOLE grapefruitextract PILL (no calories!) I was abvle to find.
here is the manufacturers site (you can order here):
http://www.getyourgrapefruit.com/
here is the press release on the product- says its made from the inside, the skin, everything.
http://www.prnewswire.com/Tbutton/B...fruitoffer.html
WI
GQ on AS!
Trevdog said:
Hmmmmm well that is a lot better. So would 10-12 oz once a day be good or is it better to take 6oz twice a day. More than likely I will be taking my Ox. in either 3 or 4 doses because of its half-life!
geoboy said:Past discussions on elite seemed to conclude that WHOLE grapefruit juice or extract was required, not just the SEED extract or narrig-something-or-another
anyways, here is the one WHOLE grapefruitextract PILL (no calories!) I was abvle to find.
here is the manufacturers site (you can order here):
http://www.getyourgrapefruit.com/
here is the press release on the product- says its made from the inside, the skin, everything.
http://www.prnewswire.com/Tbutton/B...fruitoffer.html
So is the whole grapefruit juice or extract found in local supermarkets? Also on the grapefruitextract pills, how many of those would you take daily in conjuction with your anavar pills? Thanks for the link geoboy!
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