Grapefruit juice with oxandrolone helps absorbtion?
- Thread starter ripped1979
- Start date
I have used Searle, many years ago. That was some great stuff. Within the last 3 years I have used Ttokkyo and IP. That's it. I love anavar, its just very expensive.
I split it into 2 doses because I believe that is all that's necessary given the half life. Its kind of a convenience issue.
I split it into 2 doses because I believe that is all that's necessary given the half life. Its kind of a convenience issue.
hhajdo
Community Veteran
Even some known CYP3A4 substrates like alprazolam are not affected by GFJ, so don't expect to much from taking it with AS (I've never seen AS in the lists of drugs affected by GFJ)...
It might work, so it's worth trying IMO.
Different GFJ preparations do have different impact on CYP3A4 inhibition.
Psychopharmacology (Berl). 2000 Jun;150(2):185-90. Related Articles, Links
Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam.
Yasui N, Kondo T, Furukori H, Kaneko S, Ohkubo T, Uno T, Osanai T, Sugawara K, Otani K.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Japan.
The effects of repeated ingestion of grapefruit juice, an inhibitor of cytochrome P450 3A4 (CYP3A4), on the pharmacokinetics and pharmacodynamics of both single and multiple oral doses of alprazolam, a substrate of CYP3A4, were examined. In study 1, eight healthy volunteers ingesting 600 ml/day water or grapefruit juice for 10 days took a single oral 0.8-mg dose of alprazolam on the eighth day. Plasma drug concentrations were monitored up to 48 h after alprazolam dosing together with evaluation of psychomotor function. Grapefruit juice altered neither the plasma concentrations of alprazolam at any time points, any pharmacokinetic parameters, nor the majority of psychomotor function parameters in subjects. In study 2, 11 patients with anxiety disorders receiving alprazolam (0.8-2.4 mg/day) ingested grapefruit juice (600 ml/day) for 7 days. Blood samples were collected before and during grapefruit juice ingestion and 1 week after its discontinuation together with an assessment of clinical status. Grapefruit juice altered neither the steady-state plasma concentration of alprazolam nor the clinical status in patients. The present study shows that grapefruit juice is unlikely to affect pharmacokinetics or pharmacodynamics of alprazolam due to its high bioavailability.
http://www.mhc.com/Cytochromes/GFJ.HTML
Inhibition occurs almost immediately if the gfj dose is high enough (e.g., a single glass of reconstituted frozen concentrate inhibits CYP3A4 within the first 4 hours. Schmiedlin-Ren 1997). Drug inhibition can last up to 3 days after gfj intake ceases (Tankanaga 2000a, Tankanga 2000 b).
Different preparations of gfj vary as CYP3A inhibitors. Reconstituted frozen concentrate is generally used in clinical studies, and it is a more potent CYP3A4 inhibitor than fresh gfj because gfj rind (which contains an oil that itself is a potent CYP3A inhibitor) is added to frozen concentrate during processing (Schmiedlin-Ben 1997). White gfj is a more potent inhibitor than pink gfj (Fukuda 2000).
It might work, so it's worth trying IMO.
Different GFJ preparations do have different impact on CYP3A4 inhibition.
Psychopharmacology (Berl). 2000 Jun;150(2):185-90. Related Articles, Links
Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam.
Yasui N, Kondo T, Furukori H, Kaneko S, Ohkubo T, Uno T, Osanai T, Sugawara K, Otani K.
Department of Neuropsychiatry, Hirosaki University School of Medicine, Japan.
The effects of repeated ingestion of grapefruit juice, an inhibitor of cytochrome P450 3A4 (CYP3A4), on the pharmacokinetics and pharmacodynamics of both single and multiple oral doses of alprazolam, a substrate of CYP3A4, were examined. In study 1, eight healthy volunteers ingesting 600 ml/day water or grapefruit juice for 10 days took a single oral 0.8-mg dose of alprazolam on the eighth day. Plasma drug concentrations were monitored up to 48 h after alprazolam dosing together with evaluation of psychomotor function. Grapefruit juice altered neither the plasma concentrations of alprazolam at any time points, any pharmacokinetic parameters, nor the majority of psychomotor function parameters in subjects. In study 2, 11 patients with anxiety disorders receiving alprazolam (0.8-2.4 mg/day) ingested grapefruit juice (600 ml/day) for 7 days. Blood samples were collected before and during grapefruit juice ingestion and 1 week after its discontinuation together with an assessment of clinical status. Grapefruit juice altered neither the steady-state plasma concentration of alprazolam nor the clinical status in patients. The present study shows that grapefruit juice is unlikely to affect pharmacokinetics or pharmacodynamics of alprazolam due to its high bioavailability.
http://www.mhc.com/Cytochromes/GFJ.HTML
Inhibition occurs almost immediately if the gfj dose is high enough (e.g., a single glass of reconstituted frozen concentrate inhibits CYP3A4 within the first 4 hours. Schmiedlin-Ren 1997). Drug inhibition can last up to 3 days after gfj intake ceases (Tankanaga 2000a, Tankanga 2000 b).
Different preparations of gfj vary as CYP3A inhibitors. Reconstituted frozen concentrate is generally used in clinical studies, and it is a more potent CYP3A4 inhibitor than fresh gfj because gfj rind (which contains an oil that itself is a potent CYP3A inhibitor) is added to frozen concentrate during processing (Schmiedlin-Ben 1997). White gfj is a more potent inhibitor than pink gfj (Fukuda 2000).
Drveejay11
Community Veteran
Re: Grapefruit Pills
geoboy said:Past discussions on elite seemed to conclude that WHOLE grapefruit juice or extract was required, not just the SEED extract or narrig-something-or-another.
anyways, here is the one WHOLE grapefruitextract PILL (no calories!) I was abvle to find.
here is the manufacturers site (you can order here):
http://www.getyourgrapefruit.com/
here is the press release on the product- says its made from the inside, the skin, everything.
http://www.prnewswire.com/Tbutton/B...fruitoffer.html
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