macro said:
this is innaccurate. Mixed agonists/anatagonists of the PR will impact prolactin.
you can pull 100 studies, none done with tren with night time values nor in humans.
bromocriptine works for tren based puffyness and gyno.. so if tren does not impact prolactin then it must just be the magic of bromo... though since bromo is not magic... must be...
Actually, what you're saying is innacurate... The retarded bromo idea was based on a lamb study in which tren caused hypothyroidism so an assumption was made that the same would happen in humans which would result in increased PRL levels.
If you look at the human studies you can see that AS cause mild thyroidal impairment by decreasing TBG, which results in decreased total T3 & T4, free T4 & T3 & basal and stimulated PRL levels are uneffected.
Also, nipple tenderness does not always progress to gynecomastia & drug induced gynocomastia can frequently regress after the drug which induced it is removed, so you made another WRONG conclusion.
Nandrolone, a known PR agonist, was one of the AS used in this study:
Journal of Clinical Endocrinology and Metabolism
Copyright Q 1993 by The Endocrine Society
Vol. 16, No. 4
Ingestion of Androgenic-Anabolic Steroids Induces Mild Thyroidal Impairment in Male Body Builders
ROMAN DEYSSIG AND MICHAEL WEISSEL
Third Medical University Clinic and L. Boltzmann Institute for Nuclear Medicine, A-1090 Vienna, Austria
Thirteen bodybuilders, recruited in local training centers, with normal thyroid function were investigated. Thyroid dysfunction was excluded by measurement of free Td, palpation of the thyroid, and clinical investigation. All athletes performed regular strength training up to six times a week. Five of the athletes admitted self administration of androgenic-anabolic steroids. These were obtained from nonmedical sources. The start of steroid intake was at least 6 weeks before the study. The individual doses of their self-reported “stacking regimen” (two or more different steroids simultaneously; see Ref. 12) were as follows. Testosterone was used im once or twice a week in different esters, such as
propionate, phenylpropionate, capronate, isocaprionate, and enantate.
Nandrolone (17@-hydroxy-4-e&en-3-one) was injected once a week as phenylpropionate or decanoate....
Tables 2 and 3 give the mean values and SES of the serum hormone concentrations in both groups. Basal TBG, total Ts,
and total T4 were significantly lower in the group of athletes taking steroids (Table 2), with
no significant difference in free Td, TSH, and PRL between the two groups.
Basal and stimulated PRL levels were unaffected by androgens, as has been described previously for pharmaco-logical doses in hypogonadal men (10).
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Int J Androl 1984 Feb;7(1):53-60 Related Articles, Links
Prolactin secretion in the human male is increased by endogenous oestrogens and decreased by exogenous/endogenous androgens.
Gooren LJ, van der Veen EA, van Kessel H, Harmsen-Louman W, Wiegel AR.
There is evidence that prolactin may be involved in testicular steroidogenesis, and we have therefore investigated whether there is feedback regulation of androgens/oestrogens on prolactin secretion in the human male. To assess this we have measured basal and TRH-stimulated prolactin levels in: Six eugonadal men before and after 2 weeks' administration of the aromatase inhibitor delta'-testolactone, which led to a fall in oestradiol levels with unchanged levels of testosterone. In these patients, prolactin levels decreased. Six eugonadal subjects before and after 6 weeks' administration of dihydrotestosterone undecanoate. In these subjects, prolactin levels decreased. Six agonadal subjects, tested after 12 weeks' treatment with dihydrotestosterone undecanoate and compared to: Six agonadal subjects who received no sex steroid treatment. Again, it was found that dihydrotestosterone treatment decreased prolactin levels in patients from Group C. Six eugonadal subjects were also studied before and after 6 weeks' administration of the androgen receptor antagonist, spironolactone, and this treatment increased Prl secretion.
It is concluded that in the human male, endogenous oestrogens increase prolactin secretion whilst exogenous/endogenous androgens decrease prolactin secretion.