By: Big Cat
Pharmaceutical Name: Methyltrienolone
Chemical structure: 17-methylestra-4,9,11-trien-3-one,17b-ol
Molecular weight of base: 284.3974
Brands & Products: Originally produced by Negma, but never approved for production.
Methyltrienolone is structurally similar to trenbolone (Parabolan/Finaplix), a well-liked and powerful androgen that does not aromatize to estrogen. The difference is the attachment of a 17-alpha-methyl group for oral activity. So one could refer to methyltrienolone as oral trenbolone. It was first explored quite some time ago by Negma in France, the same company that marketed Parabolan (trenbolone). But the drug was never approved by the French government and was hence never produced. The reason was extreme hepatoxicity. Bill Roberts, the biochemist, once commented that taking methyltrienolone made taking insane doses of anadrol and Halotestin together look mild on the liver. While I was unable to find anything in the literature that describes the extent of the liver toxicity, it's a generally accepted fact. That's also why, to the dissapointment of many, you will never find a commercially marketed methyltrienolone product. Its only sold in bulk to labs and universities for research studies involving androgens.......
....While many may wish that an incredibly strong androgenic, non-aromatizing compound as this was available for daily use, its not. And if the indications are true, its probably best. I've warned many people for the toxicity of fluoxymesterone, and everything points to it that methyltrienolone makes fluoxymesterone look like Tums tablets in terms of liver toxicity.
Stacking and Use:
Obviously this section is mostly useless, as any who would use, let alone stack methyltrienolone for any decent period of time, wouldn't really be around long enough to tell us how well it worked. Ideally one would use it alone, while dieting or for the purpose of gaining lean mass. The androgenic potency is slightly higher than that of trenbolone, so the risk for aggravated hair loss, acne, prostate hypertrophy and deepening of voice is not only realistic, but almost likely. If one were to use it, you would probably have to use every trick in the book to protect your liver and stay alive: Alpha Lipoic Acid, Milk thistle, dessicated liver and Vitamin B6. The blood pressure raise would not be mild either. So something to lower blood pressure is advised as well.
Of course the best advice is to refrain from using such a compound, although for 99% of the population that is not a problem, and I would assume that the 1% that does have access would know better.
2 Bonne C, Raynaud JP. Methyltrienolone, a specific ligand for cellular androgen receptors. Steroids 1975 Aug;26(2):227-32
3 Dube JY, Tremblay RR, Chapdelaine P. Binding of methyltrienolone to various androgen-dependent and androgen-responsive tissues in four animal species. Horm Res 1976;7(6):333-40
4 Tremblay RR, Dube JY, Ho-Kim MA, Lesage R. Determination of rat muscles androgen-receptor complexes with methyltrienolone. Steroids 1977 Feb;29(2):185-95
5 Baum MJ, Kingsbury PA, Erskine MS. Failure of the synthetic androgen 17 beta-hydroxy-17 alpha-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R1881) to duplicate the activational effect of testosterone on mating in castrated male rats. J Endocrinol 1987 Apr;113(1):15-20