SARMSEARCH Sponsored Log (GW-50) - Hypnotix

Logs are real life happenings. Anyone can read scientific studies, etc., but none of them involve actual bodybuilders, which is what everyone here really wants information about.
 
Alright, alright.. I know, I've gotta be the worst "sponsored" logger in all history that is "Ology".

Sue me! I'll make it up to SarmSearch for my inconsistent logging. I think I've about pinpointed my malfunction over the past few days. Cause I felt excellent today and only a single thing has changed between the past few weeks and today...

ALLEGRA.

Every day I've suffered from several allergy-like symptoms. Red, itchy, dry Eyes. Dry, cracked, bloody stuffy nose. Sinus congestion, followed by the yearly sinus infection... It's insane to me that this has been happening year after year and I've just now come to realize what it was. Today though.. I took the Allegra and have been great actually. Eliminated a lot of the "sleepy" feelings that being dry and stuffed up can bring along with it. Finally!

Okay! On to the actual good stuff. Got into the damn gym tonight. First night I haven't felt blown out after work.. coincidentally the same day I take allergy medicine for the first time ever? I think not!

Hit me Chest and Back! Fuckin destroyed it. So basically when I combine days.. this is how it goes. I'll bounce push/pull supersets, I'll do my same single day routine for each muscle group but just superset an entire other days (or muscle groups) routine and only take one rest period per superset. If it's hard to follow I'll write it out in numbers.

Superset 1 - Each set will be superset'd with the opposing muscle groups same rep range. So 15x15, 4x4, 6x6, (8,20 x 8,20) Each with 45secs-1minute of rest in between.

DB Bench Press, Bent over DB rows - 15, 4, 6, (8, 20) x 15, 4, 6, (8, 20)

Barbell Incline Press, Wide Grip Lat Pulldowns - 15, 4, 6, (8,20) x 15, 4, 6, (8, 20)

Narrow Grip Rows (No opposing supersets, Cooldown exercise) - 15, 4, 6, (8, 20)

Chest Flyes, Y-Rope Face Pulls - 20, 20, 20 x 12, 12, 12

.... So normally I would do deadlift on back day, and decline press on chest days as well. Unfortunately there isn't not enough time on my hands necessarily and adding just deadlift to this sort of routine just doesn't seem that cohesive. I go heavy on DL and do longer rest periods.. just doesn't fit for this day. In fact I think I'll do it tomorrow in my leg day!

Anyways, this sort of routine is very taxing. The back and forth on every set for 25-30 sets is tiring, and normally I'm dragging ass taking longer rest, long water breaks, huffing puffing, tonight though, totally different story! I basically just sweat like never before and kept going, and going, and going! When I got winded in my 20 rep sets of flyes, I'd pause, and then bust out more, pause, bust out more, get up walk to the face pulls, bust out 12 reps, rest for 45 seconds, back to 20 on flyes. Killin it! Absolutely loved it tonight.

This is absolutely the GW-50, and everything I've heard about it. This is what I have been waiting for. If I had just gotten into the gym sooner I'd have known by now! I will definitely be a customer and am looking forward to the coming couple of weeks with it still!
 
jozifp103 said:
Basically how it works is it flips a switch in your body causing it to turn mostly to fat as a fuel source. Normally your body prefers carbohydrates as fuel, but GW-50 switches the preferred fuel source to fat. This had a drastic effect on endurance and cardio capacity. It also makes every exercise you do a fat burning exercise. When you lift weights, you're burning primarily fat instead of carbs. This allows your muscles to maintain a greater level of glycogen storage because it is not being consumed during weight lifting. So you lose fat, and remain looking full and pumped.
Click to expand...

Sorry for arriving late to the party...

If GW-50 makes you burn ketones instead of glucose/glycogen as a fuel source, would one experience the same effects as on a Ketogenic Diet? Namely, feeling tired and weaker all the time? Don't get me wrong, ketogenic diets are great and have there place -- I just ran one for a long time -- but it is medically proven that performance improves when carbohydrates are consumed (taking one out of ketosis) and when glycogen is available. So I am confused as to why one would experience improved endurance and performance on GW-50 if it is causing one to run on ketones. What am I missing?
 
Megatron28 said:
Research on it was discontinued as it was found to significantly increase rates of cancer in mice and rats.

The other side is that it is reported to increase performance and improve lipid profiles.

GW501516 - Wikipedia, the free encyclopedia
Click to expand...

I can't speak on why it is known for its endurance qualities, I'll have to get back to you on that one. But that study done on rats was like the marijuana studies done on apes where they gave them as much marijuana smoke as someone would normally breathe oxygen in for hours on end.

Essentially the rats got 20mg a day if I remember correctly, which is the equivalent to like 400mg a day for a human..

I've heard from some people it's actually been shown in studies to aid the body in fighting off cancer..

Take all this however you want, I'll have to get back to you with the real data. Bed time here.
 
Hey Megatron, I've been thinking about the whole fat burning for energy concept and how one would feel like garbage after so long. I think you're on to something for individuals who are in a caloric deficit and a strict ketogenic diet.

However!

In my case the carbs are still present.. I'm not even doing a cyclic ketogenic diet. Just plain old eating everything.

Fat becomes the priority substance burned for energy, but once the fat runs out.. where's it gonna pull from? The carbs. In the meantime though, I'm still trying to figure out what the carbohydrates are doing stagnant. Do they get processed still, do they fill muscles with glycogen.. I'm curious to how exactly it would aid in fat loss in this manner.

Looking at it from a different perspective.. Protein would always be the last thing used up on the list. Can't go wrong there.

It's non-catabolic. Yay.

And it's known for its good work on cholesterols over anything. In fact, I said in the beginning of the log that the cholesterol part was my favorite attribute, and just a raise in my HDLs would make buying this product worth it for me.

Anyway, all I could come up with today. There really isn't a crap-ton of info out there on it.. basically I'm just trying to make logical sense of how it works.

You find anything yet?
 
For what it is worth, here is what Wiki says about the modemof action. I don't underatand exactly what it ia saying. Maybe someone can translate?

GW501516 is a selective agonist (activator) of the PPAR***948; receptor.[19] It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPAR***948; with > 1000 fold selectivity over PPAR***945; and PPAR***947;.[13]

In rats, binding of GW501516 to PPAR***948; recruits the coactivator PGC-1***945;. The PPAR***948;/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure.[20] Furthermore in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL).[20] The mechanism by which PPAR***948; agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1.[5]
 
Awesome log imo! I know it was not your main reason for trying it but have you noticed any bf change that is more than normal for your activity level and diet? I'm thinking this would be pretty nice for while off cycle and also for work reasons sense I work a rotating shift and getting tired while being out here is pretty normal. And also is there a recomended amount of time to be taking it or would it be completely ok to do this for say 3 months at a time? Congrats on the new house! And can't wait to see the bloodwork here soon!
 
Megatron28 said:
For what it is worth, here is what Wiki says about the modemof action. I don't underatand exactly what it ia saying. Maybe someone can translate?

GW501516 is a selective agonist (activator) of the PPAR***948; receptor.[19] It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPAR***948; with > 1000 fold selectivity over PPAR***945; and PPAR***947;.[13]

In rats, binding of GW501516 to PPAR***948; recruits the coactivator PGC-1a;. The PPAR***948;/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure.[20] Furthermore in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL).[20] The mechanism by which PPAR***948; agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1.[5]
Click to expand...

Basically, when you do endurance exercises the body shift from burning carbs to burning fat and glucose directly, since it can get the a large amount of energy for the least amount of effort. GW binds to PPARbeta;, which is the same receptor that is activated when the body is doing endurance exercises. When this receptor is activated, it tells the body you are in dire need of energy and so the body acts just like it has been doing endurance exercises. The fun part is that it also attracts PGC-1a;, which also binds to PPARbeta;. PGC-1a; is a human only thing, and is one of the reasons why humans can run much, much longer than any of the primates can run (even if we cannot do the same short burst speed they can do). PGC-1a; does many other things (helps us fight off hypothermia, for example), but they are unrelated here.

In short, GW activates the same receptors that are activated when you do endurance exercises (for example, you are running from a saber tooth tiger who is a tad hungry), which then turns on all the pathways the body activates when you do endurance exercises. If you then stack GW with actually DOING exercises, you should recover faster from each set due to the larger amount of energy the body is making available for use - all pulled from the easy to use energy store called fat.
 
Last edited:
Megatron28 said:
Research on it was discontinued as it was found to significantly increase rates of cancer in mice and rats.

The other side is that it is reported to increase performance and improve lipid profiles.

GW501516 - Wikipedia, the free encyclopedia
Click to expand...

I'm a week in with gw and I've been feeling pretty tired and lethargic from it. Your question about it possibly giving symptoms of a keto diet may have some merit to it. I've asked a rep about this but I don't think they fully understood my question. I've also been going near keto and wondered if it had any effect. I might up my carbs quite a bit and see if it has any positive effect.

As for the cancer study in rats I believe they were given around 400mg daily for a year from what I read.
 
Russel17401 said:
Awesome log imo! I know it was not your main reason for trying it but have you noticed any bf change that is more than normal for your activity level and diet? I'm thinking this would be pretty nice for while off cycle and also for work reasons sense I work a rotating shift and getting tired while being out here is pretty normal. And also is there a recomended amount of time to be taking it or would it be completely ok to do this for say 3 months at a time? Congrats on the new house! And can't wait to see the bloodwork here soon!
Click to expand...

The body fat part is hard to say man. I'm just generally chubby right now.. 20-25% any changes I've seen would be minimal. I've seen a little change in musculature, seem more full, a mini taste of what it was like on cycle. It's like it brought it back a little bit, I don't get as soft between workouts while I'm on GW.

The primary benefit I've seen is how much harder I can push past the point of exhaustion, set by set. How I can easily stick to a 40-45 second rest period between sets. Muscles good to go almost right away. In fact, I think I have asthma from smoking and the only thing that keeps me from just doing triple or quad set circuits in my workouts is my difficulty catching a breath. It's helped a little in that department, but I've not pushed the cardiovascular limits much.. hell, I never run..

Blood work in a week or so will show whether it's working on my cholesterol levels or not. Fingers crossed.

Lastly, the duration of use recommended universally is 4-12 weeks (10mg/day for endurance, 20mg/day for fat loss). With little to no additional side effects from doing the full 12. I've heard the fat loss occurs most after longer use of it, and of course, as mentioned with the higher dose. After 12 weeks, discontinue use for 4 weeks and you can get right back on for another 12.

One last thing.. I don't want to say it hasn't helped with my fat by any means.. it's just really hard to say. I eat so god damn much, and 3J wants me at 210 (I'm 5'8") so there's a lot of weight coming on right now.. I'm in a huge caloric surplus, and I'm not cycling carbs or running full ketogenic.. it'd be hard to say if I've lost fat, as I'm always full of water!

Anyway, thanks for reading man. Backed out on the house by the way, oh well.
 
Hypnotix said:
Hey Megatron, I've been thinking about the whole fat burning for energy concept and how one would feel like garbage after so long. I think you're on to something for individuals who are in a caloric deficit and a strict ketogenic diet.

However!

In my case the carbs are still present.. I'm not even doing a cyclic ketogenic diet. Just plain old eating everything.

Fat becomes the priority substance burned for energy, but once the fat runs out.. where's it gonna pull from? The carbs. In the meantime though, I'm still trying to figure out what the carbohydrates are doing stagnant. Do they get processed still, do they fill muscles with glycogen.. I'm curious to how exactly it would aid in fat loss in this manner.

Looking at it from a different perspective.. Protein would always be the last thing used up on the list. Can't go wrong there.

It's non-catabolic. Yay.

And it's known for its good work on cholesterols over anything. In fact, I said in the beginning of the log that the cholesterol part was my favorite attribute, and just a raise in my HDLs would make buying this product worth it for me.

Anyway, all I could come up with today. There really isn't a crap-ton of info out there on it.. basically I'm just trying to make logical sense of how it works.

You find anything yet?
Click to expand...

If you are at 20% body fat it is going to take a while for that energy source to run out. :-)
 
cybrsage said:
Basically, when you do endurance exercises the body shift from burning carbs to burning fat and glucose directly, since it can get the a large amount of energy for the least amount of effort. GW binds to PPARbeta;, which is the same receptor that is activated when the body is doing endurance exercises. When this receptor is activated, it tells the body you are in dire need of energy and so the body acts just like it has been doing endurance exercises. The fun part is that it also attracts PGC-1a;, which also binds to PPARbeta;. PGC-1a; is a human only thing, and is one of the reasons why humans can run much, much longer than any of the primates can run (even if we cannot do the same short burst speed they can do). PGC-1a; does many other things (helps us fight off hypothermia, for example), but they are unrelated here.

In short, GW activates the same receptors that are activated when you do endurance exercises (for example, you are running from a saber tooth tiger who is a tad hungry), which then turns on all the pathways the body activates when you do endurance exercises. If you then stack GW with actually DOING exercises, you should recover faster from each set due to the larger amount of energy the body is making available for use - all pulled from the easy to use energy store called fat.
Click to expand...

The part that confuses me is that the body is less efficient at using ketones (burning fat) for energy than it is using glucose. We have all heard the expression about marathoners "hitting the wall" when they run out of glycogen and switch over to burning fat. I must confess that I am still lost on how GW is theorized to improve cardiovascular endurance.
 
Megatron28 said:
The part that confuses me is that the body is less efficient at using ketones (burning fat) for energy than it is using glucose. We have all heard the expression about marathoners "hitting the wall" when they run out of glycogen and switch over to burning fat. I must confess that I am still lost on how GW is theorized to improve cardiovascular endurance.
Click to expand...

Maybe it helps our bodies use ketones more efficiently? Would be the only thing that would make sense, at least from this point of view.

The being banned by the anti-doping organization, not sure the exact name don't quote me on that.. The whole deal with that makes me suspect there was some clear evidence of it enhancing cardiovascular endurance.
 
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