I have been on TRT for about a year. I began with Andorgel but swithed to a 50mg/mL cream applied to the scrotum as recommended by the mfg. After several months of 1 mL/day my total T was over 1500ng/dL. My doctor reduced my dosage to .75mL/day but my total T is still over 1500ng/dL. I apparently absorb this stuff extremely well. I also noticed some shedding so I had my E2 sensitive and DHT tested. E2 came back <10 pg/mL and my DHT 3010 pg/mL. My PSA has been slowly increasing however still in the normal range. I have switched to applying this same compound to my inner arms. I had my T tested a few days ago but have not received the results. I don't mind high levels of DHT but this is three times upper limit. DHT is apparently driving estrogen into the lower ranges. I'm hoping that by lowering T I will also lower DHT thereby lowering my PSA.