I'm dosing GW at 20 mg/ED. You could also run it @ 10 mg/twice a day, but GW basically operates as an ER formula. [I forget what its half-life is, but it's relatively long,] Osta is similar, but S4 has a shorter half-life, which means you'd benefit from dosing twice a day. I dose S4 @25 mg X 2/ED