ironmaster
Community Veteran, HGH Guru
Well, Biggie........I pretty much already made my argument on this topic in that old Steroidology thread that was cited above. That was an excellent discussion with some smart people who showed mutual respect for one another's opinion. That thread caused me to sink an anchor here at this well-run forum.
Not much has changed in the science since then, so the issue still centers around three questions. There is no doubt that exoGH suppresses endoGH production. But how much and for how long? Not to disagree with the famous people you mentioned, but it seems to me that the case for night time injections comes from science involving the study of people with non-functioning pituitary glands. Of course, these people would want to inject before bed, because the largest percentage of endoGH is produced during REM sleep. This would be in keeping with the body's natural rhythms.
I prefer the AM/late afternoon approach, because these are times when our natural production of endoGH is nil. Even though there may be some lingering suppression by bedtime, it is not complete suppression for sure. This allows us to utilize endoGH at it's peak production time and maximize results. More bang for the buck, and exoGH ain't cheap.
And then there is the insulin problem. ExoGH causes insulin resistance. If you are moderately hypoglycemic while asleep, you won't get the most from the GH. And if you use insulin, like I do, to compliment the GH, bedtime is out of the question. If you don't use insulin, then bedtime may be OK.
Here's the kicker. I now use Nutropin Depot exclusively, so all the "time to inject" arguments are null and void. As you know, Depot releases gradually for 30 days after injecting. This dramatically changes the way I use insulin as well. I have found that modest doses of timed release all-day insulins are best with Depot.
Not much has changed in the science since then, so the issue still centers around three questions. There is no doubt that exoGH suppresses endoGH production. But how much and for how long? Not to disagree with the famous people you mentioned, but it seems to me that the case for night time injections comes from science involving the study of people with non-functioning pituitary glands. Of course, these people would want to inject before bed, because the largest percentage of endoGH is produced during REM sleep. This would be in keeping with the body's natural rhythms.
I prefer the AM/late afternoon approach, because these are times when our natural production of endoGH is nil. Even though there may be some lingering suppression by bedtime, it is not complete suppression for sure. This allows us to utilize endoGH at it's peak production time and maximize results. More bang for the buck, and exoGH ain't cheap.
And then there is the insulin problem. ExoGH causes insulin resistance. If you are moderately hypoglycemic while asleep, you won't get the most from the GH. And if you use insulin, like I do, to compliment the GH, bedtime is out of the question. If you don't use insulin, then bedtime may be OK.
Here's the kicker. I now use Nutropin Depot exclusively, so all the "time to inject" arguments are null and void. As you know, Depot releases gradually for 30 days after injecting. This dramatically changes the way I use insulin as well. I have found that modest doses of timed release all-day insulins are best with Depot.
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