everyone is going to respond to it; the question is whether you're going to respond favorably.
the body is extraordinarily intricate and adapts very well to challenges to homeostasis. there is a great deal of individual variability when it comes to this process. for some, trt is like magic, curing all their problems and then some. for others, it does nothing, or even makes them feel worse. antidepressants are perhaps a better example of this. there are tons and tons of antidepressants on the market. when it comes to comparing two, there may only be slight differences between what they do physiologically, but a night and day difference when it comes to their ability to relieve an individual of their depressive symptoms. and while a drug may work wonders for one, it will do nothing for another. while we understand theoretically what happens when we exogenously administer medications, we don't and can't know the adaptations that occur for certain, simply because everyone's physiology varies to a certain degree.