is nitric oxide worth my time

[diehard21]

i was wondering if NO2 is a good supplement. And if there is any other good supplements for gaining mass, i have creatine. my stats are 6'2 and 195 lbs

 

[Eze]

Whey Protein
Fish Oil Caps
Multi Vitamin/Mineral

These are basically all I take

 

[diehard21]

what about no2

 

[budrau]

I have tried " ALL " kinds of supplements and gave them atleast 6 months each to make sure and I had the greatest results from NO2 and Creatine. I have done both together which gave best results, and I've done both seperate, Great results. The NO2 by itself gave me more strength and endurance lifting weights, and I could definately tell a differance when I got off of them. Tehy are nothing like Gear of course; but I would personally recommend NO2.

 

[diehard21]

thx budrau

 

[jynx]

NO2 is a waste of money. It is very dangerous and will lower your blood pressure drastically, and may cause brain damage if used for a long time. But really it's nothing more than hype.

 

[smitty4]

NO2 is a waste of money. It is very dangerous and will lower your blood pressure drastically, and may cause brain damage if used for a long time. But really it's nothing more than hype.

Could you provide a reference to the statement regarding that it may cause brain damage if used for a long time?

 

[jynx]

Sure.

The study:

Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade.

Verhaar MC, Strachan FE, Newby DE, Cruden NL, Koomans HA, Rabelink TJ, Webb DJ.

Department of Nephrology and Hypertension, University Hospital Utrecht, The Netherlands. t.rabelink@digd.azu.nl

BACKGROUND: The role of endothelin (ET)-1 in maintenance of basal vascular tone has been demonstrated by local and systemic vasodilatation to endothelin receptor antagonists in humans. Although the constrictor effects mediated by the vascular smooth muscle ET(A) receptors are clear, the contribution from endothelial and vascular smooth muscle ET(B) receptors remains to be defined. The present study, in human forearm resistance vessels in vivo, was designed to further investigate the physiological function of ET(A) and ET(B) receptor subtypes in human blood vessels and determine the mechanism underlying the vasodilatation to the ET(A)-selective receptor antagonist BQ-123. METHODS AND RESULTS: Two studies were performed, each in groups of eight healthy subjects. Brachial artery infusion of BQ-123 caused significant forearm vasodilatation in both studies. This vasodilatation was reduced by 95% (P=.006) with inhibition of the endogenous generation of nitric oxide and by 38% (P<.001) with coinfusion of the ET(B) receptor antagonist BQ-788. In contrast, inhibition of prostanoid generation did not affect the response to BQ-123. Infusion of BQ-788 alone produced a 20% reduction in forearm blood flow (P<.001). CONCLUSIONS: Selective ET(A) receptor antagonism causes vasodilatation of human forearm resistance vessels in vivo. This response appears to result in major part from an increase in nitric oxide generation. ET(B) receptor antagonism either alone or on a background of ET(A) antagonism causes local vasoconstriction, indicating that ET(B) receptors in blood vessels respond to ET-1 predominantly by causing vasodilatation.


PubMed


Here lies the problem; vasodilatation causes a drop in blood pressure (because as the veins widen, the pressure drops). Baroreceptors in the aortic arch and in the carotid sinus will detect this fast, sudden drop. In order to protect the body from going into shock, vasomotor centers in the medulla will cause the blood vessels to the brain to constrict in order to increase blood pressure going into the brain (too much blood can severely damage the brain, just like too little). This is a dangerous sequence that can potentially lead to catastrophe!

Keep this in mind the next time you consider using any supplement that claims prolonged pump due to nitric oxide synthesis.

Here are some links to the effects of nitric oxide synthesis:

http://www.imakerala.org/nitricoxide1.htm

http://www.gla.ac.uk/departments/ibls/GradSchool/2002/cardio.htm

http://physiology.cup.cam.ac.uk/Proceedings/Abstracts/523P/Chile/Files/S68.html

http://physiology.cup.cam.ac.uk/Proceedings/Abstracts/523P/Chile/Files/S63.html

http://physiology.cup.cam.ac.uk/Proceedings/Abstracts/523P/Chile/Files/S71.html

http://physiology.cup.cam.ac.uk/Proceedings/Abstracts/523P/Chile/Files/S72.html

http://physiology.cup.cam.ac.uk/Proceedings/Abstracts/523P/Chile/Files/S73.html

http://physiology.cup.cam.ac.uk/Proceedings/Abstracts/523P/Chile/Files/S74.html

http://physiology.cup.cam.ac.uk/Proceedings/Abstracts/523P/Chile/Files/S75.html

http://physiology.cup.cam.ac.uk/Proceedings/Abstracts/523P/Chile/Files/S76.html

http://physiology.cup.cam.ac.uk/Proceedings/Abstracts/523P/Chile/Files/S78.html

http://content.nejm.org/cgi/content/short/328/23/1659

http://ehpnet1.niehs.nih.gov/docs/1998/Suppl-5/1139-1143shah/abstract.html

 

[smitty4]

Here lies the problem; vasodilatation causes a drop in blood pressure (because as the veins widen, the pressure drops). Baroreceptors in the aortic arch and in the carotid sinus will detect this fast, sudden drop. In order to protect the body from going into shock, vasomotor centers in the medulla will cause the blood vessels to the brain to constrict in order to increase blood pressure going into the brain (too much blood can severely damage the brain, just like too little). This is a dangerous sequence that can potentially lead to catastrophe!

Then meds like Viagra and Cialis would result in the same type of response, would they not. They cause vasodilation too.

 

[diehard21]

good point smitty

 

[jynx]

Then meds like Viagra and Cialis would result in the same type of response, would they not. They cause vasodilation too.

No they wouldn't. Viagra dosages are so small(50mg) that it would not have nearly the effect of an NO2 supplement. You tell me the average dosages for NO2 as I have never taken it. Then compare that dosage in mg to Viagra, you see what I mean? NO2 is more severe in its vasodilation process and over time will cause brain damage from it.

 

[smitty4]

No they wouldn't. Viagra dosages are so small(50mg) that it would not have nearly the effect of an NO2 supplement. You tell me the average dosages for NO2 as I have never taken it. Then compare that dosage in mg to Viagra, you see what I mean? NO2 is more severe in its vasodilation process and over time will cause brain damage from it.

Umm...I have no idea what the average dose of NO2 is. I have never taken it. I tend to pose questions in an attempt to learn. In that process, I tend to pursue things from different angles hoping that everyone can learn from the discussion that evolves.

 

[jynx]

http://www.virileplex.com/arginine.htm - Make sure to read the whole thing, and take a good look at the last sentence.

Oh and the average does for NO2 is about 3g. It's not made of the same chemical, but Sildenafil citrate(Viagra) and L-Arginine are both known to help with erection problems. However, such a small does of each is required which causes monir vasodilation. NO2 on the other hand severly lowers blood pressure which can cause brain damage as shown in the study I posted.