Ozzy27 said:
Yo SB , I totally disagree 100%
Show me your proof on this. Please back-up your statement.
Check out post #37 in this thread.......
Jacobs et al. Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Am J Med 2002 Oct 15;113(6):506-15
PURPOSE: We performed a systematic review of the literature to determine the efficacy and safety of milk thistle for the treatment of liver disease.
METHODS: blah, blah....Outcomes of primary interest included mortality, histological findings on liver biopsy specimens, serum aminotransferase and albumin levels, and prothrombin times.
RESULTS: Fourteen trials met inclusion criteria. Four trials reported outcomes for mortality among 433 participants. The overall summary odds ratio for mortality in the milk thistle group compared with placebo was 0.8 (0.5 to 1.5; P = 0.6.....not significant!).
Three trials assessed histology on liver biopsy; study quality was inversely associated with the likelihood of histological benefit for milk thistle compared with placebo.
There were no differences in serum ALT, AST, albumin levels, or prothrombin times, among participants assigned to milk thistle compared with those assigned to placebo.
The only statistically significant difference was a greater reduction in ALT levels among patients with chronic liver disease assigned to milk thistle (-9 IU/L, 95% CI: -18 to -1 IU/L; P = 0.05), but this reduction was of negligible clinical importance and no longer statistically significant after limiting analyses to studies of longer duration or of higher quality.
The frequency of adverse effects was low and, in clinical trials, indistinguishable from placebo.
CONCLUSION: Treatment with milk thistle appears to be safe and well tolerated. We found no reduction in mortality, in improvements in histology at liver biopsy, or in biochemical markers of liver function among patients with chronic liver disease.
Data are too limited to exclude a substantial benefit or harm of milk thistle on mortality, and also to support recommending this herbal compound for the treatment of liver disease.
There's all the proof you need that it doesnt work. You can search all you want, you wont find better evidence.
Meta-analyses are at the top at the hierarchy of evidence, so dont waste your time looking for RCT's, observational studies, or case reports.
Find a meta-analysis that proves it works (which you wont), then I will agree.