Raloxifene (Evista) better than nolva - gyno beware

[BigRonWannabee]

Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.

http://www.ncbi.nlm.nih.gov/entrez/..._uids=15238910&query_hl=3&itool=pubmed_docsum

OBJECTIVES: To assess the efficacy of the anti-estrogens tamoxifen and raloxifen in the medical management of persistent pubertal gynecomastia. STUDY DESIGN: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene). RESULTS: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients. CONCLUSION: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.

PMID: 15238910 [PubMed - indexed for MEDLINE]


Sure the study is done with pubertal gyno, but the results are pretty intiguing none the less. I often get gyno flare-ups while on heavy cycles and honestly, looking forward to the next flare-up so I can try this Ralox on myself.

Anyone started using it yet for post cycle therapy (pct) or otherwise?

 

[Insane_Man]

Interesting. What is the dosing scheme like for this shit? For prevention and PCT...

 

[BigRonWannabee]

30-40mg, I personally know one guy who used 30mg/d to address some SERIOUS gyno and had rather amazing results. Im hoping this is the letro killer for existing gyno. He used a maintenance dose of 15mg/d for the rest of his cycle.

Im most interested in it for PCT, because in my eyes its pretty damn effective for gyno, but almost completely untested/unproven in the HPTA arena.

 

[goiterjoe]

I used raloxifene for my last post cycle therapy (pct) after a 16 week cycle, along with letro and tamoxifen. by the end of 4 weeks my nuts had grown back to larger than they have ever been before in my life, and my sex drive was completely restored and then some. I'll be using this from now on with PCT, although I think I'll keep the tamoxifen along with it.

 

[BigRonWannabee]

Good stuff thats exaclt what I wanted to hear!

 

[Thoms]

OK now I'm interested...
Dougoe are you going to carry it in 518-research?

 

[BigRonWannabee]

Way ahead of you thoms ralox is one of my best sellers, which got mer interested in using it myself.

 

[Vegas]

Anyone started using it yet for post cycle therapy (pct) or otherwise?

I just wrote a profile on it for another site and know of at least a couple of guys that will be running it for post cycle therapy (pct) for the first time. It's going to be interesting to see what they think of it.

 

[BigRonWannabee]

Excellent aboot, keep me updated!

 

[DocJ]

Ok you've convinced me, I'll make sure it's on board for post cycle therapy (pct) in Sept and let everyone know how it goes.

 

[GymLift]

http://www.dogflu.ca/07132006/09/raloxifene_may_prevent_breast_cancer_at_a_serious_price

 

[BigRonWannabee]

Better not take it for 5 years straight

 

[BigRonWannabee]

DRUG INTERACTIONS: Raloxifene may slightly reduce the ability of blood to clot and thus increase the effects of medications that reduce clotting (blood thinners). Therefore, if raloxifene is given with blood thinners such as warfarin (Coumadin), the ability of blood to clot may need to be monitored more closely with frequent measurements of the prothrombin time of blood.

I love studies btw

 

[DocJ]

...also good thing we're not post-menopausal women! Well most of us aren't.

 

[BigRonWannabee]

So many jokes...

 

[mick-g]

I used raloxifene for my last post cycle therapy (pct) after a 16 week cycle, along with letro and tamoxifen. by the end of 4 weeks my nuts had grown back to larger than they have ever been before in my life, and my sex drive was completely restored and then some. I'll be using this from now on with post cycle therapy (pct), although I think I'll keep the tamoxifen along with it.

What was your dosaging?

 

[simpllyhuge]

yo dougue i sent u a pm so i didnt hicjack your thread

 

[BigRonWannabee]

replied

 

[OC Cartel]

I just wrote a profile on it for another site and know of at least a couple of guys that will be running it for post cycle therapy (pct) for the first time. It's going to be interesting to see what they think of it.

can you post a link to said profile or PM me it pls?

 

[OC Cartel]

30-40mg, I personally know one guy who used 30mg/d to address some SERIOUS gyno and had rather amazing results. Im hoping this is the letro killer for existing gyno. He used a maintenance dose of 15mg/d for the rest of his cycle.

Im most interested in it for PCT, because in my eyes its pretty damn effective for gyno, but almost completely untested/unproven in the HPTA arena.

how long did your friend use the stuff @ 30mg/day for?