Interesting. A guy who calls himself "Schumaker" shows up here, for his VERY FIRST POST EVER, to attack me. Did you think we wouldn't immediately catch onto your game? Hmmm...come on, Dude, we don't need that kind of sleaziness in this thread. We are trying to make this about the medicine involved now.
Bill Roberts has been unfairly attacked on the Boards, too, IMPO. He has done a lot for the science involved, and has always been a true gentleman. He gave me a lot of good advice a couple of years ago when I really needed it, and, as always, I shall never forget that.
When Bill told everyone to never take more than 1000IU per day, you have to understand THAT was somewhat revolutionary at the time. Look how many so-called "guru's" were advocating 2500, even 5000IU per day--and STILL do.
However, following more study, and labwork done on my patients, I decided to trim that number down even further. My ceiling is 500IU per day. Going over that dose is just more than the testes can use (which is also a waste of money--I always try to keep costs down for my guys), and dramatically increases aromatase activity. My testosterone replacement therapy (TRT) patients start at 250IU on the day of, and the day immediately previous to, their test cyp injections. The several reasons why I invented that particular protocol has been explained several times on this Board already, I think. If 250IU at a time is not enough, then we gradually increase the dose, with a maximum of 500IU per shot. If THAT isn't enough still (uncommon) then we reduce the dosage back down, and simply add in more days per week. Patient complience can be a problem sometimes, although not in this particular patient population.
As far as using 500IU every day, I recommended that, too, for awhile, for my Anabolic Androgenic Steroids (AAS) patients who wanted to do it. BTW, I never claimed this as my invention. However, I was the first to recognize that HCG is useful for HPTA suppressed individuals because it helps re-balance all three hormonal pathways (mineralcorticoids, glucocorticoids as well as the sex hormones) which are built from CHOL by stimulating the P450 SCC enzyme, as LH does, and therefore is healthful. Indeed, we see reduced pregnenolone concentrations (first step from CHOL, via the P450SCC enzyme, before branching to the three pathways) in HPTA-suppressed individuals. True Hormone Replacement Therapy (HRT) Medicine considers all players in the "hormonal symphony" and seeks to maintain proper balance amongst them.
I don't know what Bill's experience with this regimen is, as I have not had a chance to talk to him about it yet, but I found that 500IU per day--every day--is too much. Quite a few of the guys who tried it reported back that their testicles were becoming "mushy" from that much Human Chorionic Gonadotropin (HCG). I think it might be due to loss of germinal tissue, which comprises about 85% of testicular mass, and requires FSH (which has comparable moiety to HCG, but very little activity therof). I don't think I have anyone who uses my daily HCG/weekly test cyp protocol (also new to testosterone replacement therapy (TRT) medicine) using over 300IU per day for that reason.
Just last week a guy came to me TOTALLY messed up hormonally from steroid use. You would recognize his face, as he has been on the covers of numerous magazines. He went to an Endocrinologist for his problems, who put him on 1750IU of HCG EOD. He was really bummed, as anyone would be, because he was still totally impotent (used Deca). Unfortunately, he had already tried Viagra, Levitra and Cialis, without response. As he was now under my care, I immediately switched him to 500IU per day (for a short run). Within a few days he reported back that he had achieved full sexual status. In fact, I think he worded it that "he had one hell of a good weekend". That is a pretty good day to be a doc! We are now moving his treatment regimen into the next phase.
A clarification should be made, too. Many Anabolic Androgenic Steroids (AAS) imbibers consider their last shot of steroids to be the end of their cycle. By the half-life of all meds involved, it cannot be thought of that way. Therefore using HCG for a week or ten days following that last injection is still using it "at the end of the cycle". THAT is how we were doing it way back in 1981, the year of my first steroid cycle. Funny, the more things change, the more they stay the same. I am just tuning up the quote from Mr. Roberts, as I am confident he would not mind.
As we go on, astute observers are finding that HCG is a much more powerful (and, I think, wonderful) hormone than we previously appreciated. Yet I STILL hear of Endocrinologists using 5000IU at a crack. They obviously do not know as much about HCG as we do here.