High Human Chorionic Gonadotropin (HCG) dosage

[slim]

High HCG dosage

Hi
Higher doses of HCG overly stimulate testicular aromatase, which inappropriately raises estrogen levels ... which is bad for Leydig cells, but if I use arimidex, there should be no problem ?

 

[Hells]

why do you want to use a high dose? Just use enough to make your balls full again.

 

[thejpman]

why do you want to use a high dose? Just use enough to make your balls full again.

I just can agree with hells even if you use a-dex use a normal HCG amount ( 300/500iu in the cycle E4D)

 

[diesel]

I used 2500iu shot once....I had been on for 8+ months, and not aware that using smaller more frequent does was better..newb.
Hell...I had to jerk it 3x's ed just to maintain composure....And I was still using letro and nolva ed. but got bloated.. about 6lbs water...it dropped after 1 week

 

[slim]

why do you want to use a high dose?

I got 5000UI HCG and already finished 10 weeks cycle.
I thought about spliting Human Chorionic Gonadotropin (HCG), but if its not necessary what for ?

Just use enough to make your balls full again

More HCG more test

 

[Mudge]

Someone posted a study showing how response with higher doses was a lessening return as the doses climbed anyway, so I'd rather spread it out.

 

[SWALE]

Has anyone seen a study that shows HCG directly stimulates the aromatase enzyme?

 

[JohnnyB]

More HCG more test [/B]

That's not ture, hcg simulates LH which simulate test, but to much can have a negitive effect

JohnnyB

 

[JohnnyB]

Someone posted a study showing how response with higher doses was a lessening return as the doses climbed anyway, so I'd rather spread it out.

Here it is

Posted by hhajdo

Differential effect of single high dose and divided small dose administration of human chorionic gonadotropin on Leydig cell steroidogenic desensitization.

Smals AG, Pieters GF, Boers GH, Raemakers JM, Hermus AR, Benraad TJ, Kloppenborg PW.

This study compared the effect of a single high dose of hCG (1500 IU) with that of the same dose administered in multiple small doses (300 IU, once daily for 5 days) on Leydig cell steroidogenesis. Administration of a single high dose of hCG to seven healthy men raised the mean plasma testosterone (T) level to peak levels 2.1 +/- 0.2 (SEM) X the baseline value at 48 h. Thereafter plasma T decreased to below normal (0.7 +/- 0.1 X baseline) 7 days after the injection. The mean 17-hydroxyprogesterone (17-OHP) level peaked at 24 h (2.5 +/- 0.2 X baseline) and then also fell to a nadir value of 0.6 +/- 0.2 X baseline on day 7. Reflecting the early accumulation of 17-OHP over T, the 17 OHP/T ratio reached its maximum (1.6 +/- 0.1 X baseline) at 24 h at the same time when plasma estradiol [(E2) 4.4 +/- 0.6 X baseline] and the ratio E2/T (2.7 +/- 0.3 X baseline) achieved their maximal values. Administration of 1500 IU hCG in five divided doses of 300 IU daily increased the mean plasma T levels to peak value of 2.1 +/- 0.2 X baseline at 5 days and the levels remained elevated thereafter. The response of T as reflected by the area under the curve was almost twice as great as in the single dose study (2844 +/- 360 vs. 1647 +/- 214). In contrast to the single high dose experiment, mean plasma 17-OHP levels in the divided dose protocol did not peak at 24 h but only gradually increased. As the increase of T exceeded the 17-OHP increase at almost all time intervals, no accumulation of 17-OHP over T occurred as in the single dose experiment. Instead the 17-OHP/T ratio fell to a nadir value of 0.6 +/- 0.1 X baseline on day 7. The initial E2 peak was absent in the divided dose protocol and the E2/T ratio only marginally increased. Considering both experiments together a close relation was found between the hCG-induced increases in E2 and 17-OHP (r = +0.88, P less than 0.001), as well as the ratio 17 OHP/T (r = +0.64, P less than 0.02).

JohnnyB

 

[atali]

so what should one do like in my case,i only have 5000iu amps. I cant devide that little coocie in the jar into 10. and even if i could get me some more solvent to make 10ml out of one coocie,what can i store it in to maintain sterile? i just figure that 500iu eod=5000iu e10d

 

[LAWNSAVER]

Pre load your pins and put them in the frig.

Higher doses of HCG can and usually will cause a desesitation to natural LH.

Keep it low and more often!