I've done an epistrong cycle once at 30mgs/day and i've also used letro and prami in an attempt to get rid of my gyno that i acquired during puberty. The letro worked but when i tapered down it came back. This time i was going to use epistrong and letro and prami together to see if that wont work. Difference is this time i'm going to switch over to aromasin to prevent rebound. Im going to use n2 guard for cycle support. And for post cycle therapy (pct) i'm going to use unleashed and post cycle and forma stanzol. Does any one have any critiques or advice?
Epistrong cycle while trying to reverse gyno
- Thread starter tman86x
- Start date
BigKevKris
New member
I would run clomid or nolva in PCT...along with the other....Faster recovery and they can also help with the gyno. Personally if my sole goal was to get rid of gyno I would try running something like forma stand alone....or have you tried straight anti-e's yet?
well i have two goals and that is to get rid of gyno while also gaining some strength. And no i haven't tried anti-e's to get rid of it because i've been told letro is the only thing that can get rid of preexisting gyno. And i thought aromasin could take the place of the nolva. I could be wrong but that's why i'm asking for opinions.
My thinking though with this cycle is that I don't want to lose strength while trying to reverse my gyno and I've also heard epistrong decreases estrogen too. So I figured it would be a good ph to use while doing this. Anyone else have any suggestions? Thanks for the input I'm just putting my reasoning out there. Is there a specific reason it's not good to do both at the same time?
BigKevKris
New member
^This....try PES Erase....or Triazole.... should make a good dent in it.
after you taper your letro, start nolva as you would for post cycle therapy (pct). This will help with the estro rebound that the letro can cause. Also I would just work out rather than try to keep taking testo boosters. I tried this when I was young and stupid years back and know have a nice little knot in my chest that reminds me that I should have read and researched prior to popping pills. Good Luck
BigKevKris
New member
What I recommended were not test boosters....some of the strongest OTC AI's available...and The little gyno I had under my left nip disappeared with a week of using Erase.....
i dont understand why you would want to run another cycle before fixing your exsisting issue. Is a few lbs of muscle worth the risk? seems to me your long term health is a tad more important.
But now that you did it....i would take the advice of nerd and BigKev...they know their shit....
But now that you did it....i would take the advice of nerd and BigKev...they know their shit....
BigKevKris
New member
It's cool.....I agree with you. I would definitely take care of the gyno first....I wouldn't want to take the chance of making it worse.
Needtogetaas
Official Sponsor
first off YOU DO NOT NEED CLOMID AND OR NOLVA FOR post cycle therapy (pct)!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
What Is Nolvadex/Tamoxifen?
Tamoxifen is considered as the antagonist of the estrogen receptor which again is primarily present in the breast tissue of the human body. It is interesting to note that certain breast cancer cells require that the estrogen levels need to grow with passing time. Ideally, Tamoxifen has been used as the standard endocrine for the treatment of early breast cancer patients. It is therefore used as an anti estrogen therapy and it is mainly given to postmenopausal women. The role of an estrogen is to bind as well as activate the estrogen receptors that are present in the breast cells of a human body. The role of Tamoxifen is to stop estrogen to bind with the receptor. Although it is metabolized into compounds that aid in the binding of estrogen receptors, Tamoxifen does not allow the estrogen receptors to get activated in the breast cells of the human body. Hence, the growth of breast cancer cells can be stopped by making use of this compound. Nonetheless, results vary from person to person and the use of Tamoxifen cannot be deduced as a permanent cure for breast cancer patients.
It is ideally a drug which is taken orally in the form of an edible tablet and it is known to interfere with the activity of the estrogen levels present in the breast tissue. It has been studied that unless the estrogen levels in the human body are kept under strict control, they can lead to breast cancer. Tamoxifen has primarily been used for the past 30 years for treating patients suffering from breast cancer. It has also been administered to patients who are in their early stages of breast cancer. Even patients whose breast cancer has spread to various parts of the body have been known to use Tamoxifen on a regular basis. It has been stated that this drug has the ability to stop cancer cells from spreading within the human body but ironically there is no substantial study which clearly backs this statement with the help of substantial proof. Nonetheless, owing to the hype that it has received via media, people who are having breast cancer or those women who run the risk of developing breast cancer have been known to take this medicine on a regular basis. Interestingly, it has also been seen that women who are suffering from ductul carcinoma in stu, which in turn is similar to invasive breast cancer, have also been known to administer this medicine on a regular basis.
In the past 20 years steroid users have been using nolvadex for a number of reasons. To ether help reduce bloat or gyno problems during a cycle or after a cycle to help recovery natural test production. In men, tamoxifen "nolvaldex" is sometimes used by steroid-taking, weight-training athletes.An alternative and highly similar compound is clomiphene citrate "clomid". These drugs are used as anti-estrogen therapy. In this regard, the drug is used for three purposes. The first purpose, is to reduce the effect of circulating estrogens even if Tamoxifen itself increase the circulating level of estrogens since they are not bound to the estrogen receptors. Abnormally high levels of estrogen in men, can be caused by taking highly aromatizing anabolic steroids e.g. Dianabol, Anadrol or Testosterone. In dosing with a dosing with 20 mg of Novaldex (Tamoxifen) for the duration of a steroid cycle, a reduction in water retention can be achieved. This prevents large fluctuations in water weight within the muscle.
Using Tamoxifen for the duration of a steroid cycle may or may not promote a preferable outcome for a weight training athlete, as the temporary increase in water weight within the muscle increases strength and allows larger weights to be used for the duration of the steroid cycle. Said water will dissipate once usage of steroids has ceased, and a dramatic loss in weight can be observed. Tamoxifen is also used to prevent estrogen related gynecomastia, resulting from elevated estrogenic levels. It can be taken as a preventative measure in small doses, or used at the onset of any symptoms e.g. nipple soreness/sensitivity. In the latter case, dosing reverses the affliction
However it Is now well known that well taking nolvadex serum level estrogen raises and yet another drug must be taken with it during cycle,during post cycle therapy (pct),or after post cycle therapy (pct) to prevent estrogen rebound. (how retarded). Studies have of course shown the its use can cause a rise in lh and test production but at what cost? Many other factors must be taken into account.
All this is happening in complete ignorance as they are not aware that this medicine has certain side effects that can prove fatal in the longer run. At the same time robbing ones self of a better post cycle therapy (pct) and cycle from using drugs like this.
Though I do feel its "ok" to use them "if you must" but use as little as you can and use support/post cycle therapy (pct) sups to help alleviate the side effects and bad feelings one gets from these harsh drugs.
Where Was This drug Discovered?
Interestingly, this drug was discovered by AstraZeneca Pharmaceuticals which were earliest known as ICI pharmaceuticals. It is now sold under various trade names such as Nolvadex, Valodex and Istubal. Although it is sold under various names, it is primarily known and popularly termed as Tamoxifen. Although this drug is widely used in treating breast cancer patients, it also has adverse side effects which very few people are actually aware off.
Once praised for its benefits in preventing breast cancer recurrence, the lucrative pharmaceutical drug tamoxifen is now implicated in causing dangerous side-effects, including other types of cancers.
In the early 1970's, a shameful chapter closed on the widespread use of a known carcinogenic and endocrine-disrupting drug called DES (diethylstilboestrol), the first synthetic, non-steroidal estrogen drug. Against the advice of its creator, Sir Charles Dodd, between four and six million American and European women and 10,000 Australian women innocently used DES for the prevention of miscarriage and pregnancy complications.
In addition, DES became a popular though unproven drug for a variety of other conditions. It was used for the suppression of lactation, the treatment of acne, the treatment of certain types of breast and prostatic cancer, and as an inhibitor of growth in young girls, an estrogen replacement in menopause and a "morning after" pill.
It would take 30 years to accept what laboratory tests had indicated as early as 1938 — that DES was a highly dangerous and harmful drug. It was reported that, 20 years after taking DES, mothers had a 40 to 50 per cent greater risk of breast cancer than non-exposed mothers. In addition, the children of DES mothers showed a high incidence of reproductive abnormalities, miscarriages, vaginal cancer, testicular cancer, sterility and immune dysfunction. In fact, it is feared that repercussions of this drug will be felt for generations to come.
The irony of this entire debacle is that the medical establishment finally acknowledged that DES was useless in preventing miscarriages. Thus, DES, another disastrous experiment on women, was added to the long list of major medical blunders.
Out of this early research, a new drug appeared on the horizon which would be soon be heralded as a shining star in the war against the growing epidemic of breast cancer. In the late 1960's the pharmaceutical industry developed a drug called "tamoxifen". As a synthetic, non-steroidal compound with hormone-like effects (many of which are poorly understood), tamoxifen has a similar structure to DES. In fact, it was observed that tamoxifen caused the same abnormal changes seen in cells of women taking estradiol and DES. This similarity raised alarm bells for some.
Pierre Blais, well known as a drug researcher who was ejected from Canada's health protection bureaucracy when he spoke out about silicone breast implants, describes the story of tamoxifen as "the story of modern drug design which produces garbage drugs". He says, "Good drug design ceased, unfortunately, in the 1930s." Tamoxifen, Blais asserts, "...is a garbage drug that made it to the top of the scrap heap. It is a DES in the making."
Blais's dire predictions were ignored with the promise of a potential drug treatment for breast cancer. Tamoxifen was first approved by the US Food and Drug Administration (FDA) for use as a birth-control pill; however, it proved to induce rather than inhibit ovulation.(just goes to show how retarded they truly are) Although tamoxifen didn't work as a contraceptive, it was found to lower mammary cancer rates in animals. Animal studies showed that tamoxifen prevented estrogen from binding to receptor sites on breast tissue cells. Tamoxifen also reduced the incidence of breast cancer in rodents after administration of a breast-carcinogenic substance. This discovery provided the impetus to study its effects in treating human breast cancer.
Estrogen is the common link between most breast cancer risk factors, i.e., genetic, reproductive, dietary, lifestyle and environmental. It both stimulates the division of breast cells (healthy as well as cancerous) and, especially in its 'bad' form, increases the risk of breast cancer. Thus, hormonal drugs such as tamoxifen that block the effects of estrogen on the breast were expected to reduce the risk of breast cancer recurring in women treated for breast cancer.
Tamoxifen acts as a weak estrogen by competing for estrogen receptors much as phyto-estrogens do(I want you to keep this word PHYTO ESTROGENS IN MIND WE WILL COVER IT AGAIN LATER). Like phyto-estrogens, tamoxifen has mild estrogenic properties but is considered an anti-estrogen since it inhibits the activity of regular estrogens. More accurately, tamoxifen is an estrogen-blocker(Not a estrogen reducer)
HORMONAL EFFECTS OF TAMOXIFEN IN OLIGOSPERMIC MEN -- WILLIS et al. 73 (1): 171 -- Journal of Endocrinology
Yes the test shows over time that both lh and androgins were raised, but at the same time (serum level estrogen was tripled)and thus the reason many experence rebound gyno after its use.
Tamoxifen fights breast cancer by competing with estrogen for space on estrogen receptors in the tumor tissue. Every tamoxifen molecule that hooks onto an estrogen receptor prevents an estrogen molecule from linking up at the same site. Without a steady supply of estrogen, cells in an estrogen-receptor-positive (ER+) tumor do not thrive and the tumor's ability to spread is reduced.
However, tamoxifen exhibited two conflicting characteristics. It could act either as an anti-estrogen or as an estrogen. Therefore, while tamoxifen is anti-estrogenic to the breast, it also acts as an estrogen to the uterus and, to a lesser extent, the heart, blood vessels and bone. Moreover tamoxifen also acts as an estrogen in the liver thus causing the lowering of IGF-1
In This Issue -- 82 (21): 1661 -- JNCI Journal of the National Cancer Institute
http://cancerres.aacrjournals.org/cgi/reprint/49/7/1882.pdf
Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women
Comparison of Tamoxifen and Testosterone Propionate in Male Rats: Differential Prevention of Orchidectomy Effects on Sex Organs, Bone Mass, Growth, and the Growth Hormone-IGF-I Axis -- Fitts et al. 25 (4): 523 -- Journal of Andrology
For people suffering from breast cancer I guess this would be a good thing. Since Lowering IGF would reduce the growth of everything. However this is not one any of the people using nolva for post cycle therapy (pct) or on cycle use want now is it?
So, although it initially showed the tendency to counter breast cancer recurrence, it would soon be revealed that it also promoted particularly aggressive uterine and liver cancers, caused fatal blood clots and interfered with many other functions.
Doctors, however, were quick to jump on the tamoxifen bandwagon, turning a blind eye to its more injurious tendencies. Starting in the 1970's oncologists began using tamoxifen to treat women with cancer, often in combination with other drugs, radiation or surgery such as lumpectomy and mastectomy, with modest success. Like DES, tamoxifen's benefits were then extended for use as a preventive against osteoporosis and heart disease.
Today, doctors are treating about one million American breast cancer patients with tamoxifen, about 20 per cent of them for more than five years. As studies published in the New England Journal of Medicine in 1989 and the Journal of the National Cancer Institute in 1992 showed, women with breast cancer who took tamoxifen reduced their chances of developing cancer in the other breast (contralateral cancer) by about 30 to 50 per cent. These findings would later be challenged.
Tamoxifen is now recommended for all pre-menopausal women with hormone-positive cancers, as well as for most postmenopausal women with breast cancer and/or a growing number of women with hormone-negative cancers. Tamoxifen is currently used by more women with breast cancer than any other drug.
Tamoxifen (brand name Nolvadex) is now the most widely prescribed cancer medication in the world. It generated revenues of US $265 million in 1992. By 1995, worldwide sales of Nolvadex reached $400 million. (7) And at AUD $90 for one month's supply, it doesn't come cheap (the Australian Pharmaceutical Benefits Scheme covers $70).
Global sales of tamoxifen in 2001 were $1,024 million.[54] Since the expiration of the patent in 2002, it is now widely available as a generic drug around the world. Barr Labs Inc had challenged the patent (which in 1992 was ruled unenforcable) but later came to an agreement with Zeneca to licence the patent and sell tamoxifen at close to Zeneca's price.[55] As of 2004, tamoxifen was the world's largest selling hormonal drug on record and off record may be the number 1 selling drug in word of all time to date. So we are truly talking about billions in revenue world wide for drug companies,sources,ug's and more. Money is at the root of this drug and why its so heavily pushed on all forums by everyone. Its cheap to make and it brings in billions plain and simple.
These numbers are nothing compared to what this drug now makes for the drug companies,sources.ug's selling it. So you can bet your life they will make sure every test and study in the world is published to make sure its seen in a good light. This not even including its "off label use" Ie all us men using it for on cycle and post cycle therapy (pct). The use of the drug for this reason triples its sales and you can just emagen the amount of money its making. You do the math my friends!. At this very moment 500000000 sources and people with monitary ties to this drug are out there pushing like crazy to make sure you and everyone else keeps its use for post cycle therapy (pct) alive. This is the #1 reason why we have not given up on this years ago.
Tamoxifen was developed by UK-based Imperial Chemical Industries (ICI), one of the world's largest multinational chemical corporations. Zeneca, an ICI subsidiary, is responsible for manufacturing and marketing the hormone and is now the world's largest cancer-drug company.
CARCINOGENENIC EFFECTS
It wasn't long before laboratory studies showed that tamoxifen acted as a carcinogen. It has been found that tamoxifen binds tightly and irreversibly to DNA, the genetic blueprint of a cell, causing a cancerous mutation to take place. Even Australia's conservative National Health and Medical Research Council (NHMRC) warned that no amount of tamoxifen is safe when it comes to carcinogenic effects.
In California there is a law called "Proposition 65" that requires the state to publish and maintain a list of all known carcinogens. In May 1995, the state's Carcinogen Identification Committee voted unanimously to add tamoxifen to its list.
When research is done on anti-cancer drugs (such as SERMs), the aim is to find a drug that prolongs life, with the least amount of acute side-effects. In other words, the goal isn’t so much about finding a cure, as it is finding something that can alleviate the symptoms and/or prolong life.
When it comes to steroid users so many are willing to forgo any and everything to get the one simple effect they desire (recovery). The popularity of these drugs stems from the popular advice to use these drugs for everything from testosterone recovery.bitch tits,make your dick grow bigger, increase the amount of jiz you drop on a girls face, and everything in between. Advice on its use is handed out like candy and everyones got a sweat tooth for quick advice. Of course many "vets and so called know it alls" defend it to the death and it can do no wrong. Mainly do to not wanting to be wrong,habit,they got money involved with it, or just for the sake of argument.
“Its FDA approved for cancer treatment. It must be safe!”
It’s wrong to assume that an “FDA approved” drug has a proven safety profile. The FDA has continually issued stronger health warnings for tamoxifen over the years. For instance, in 1994 the FDA demanded that the tamoxifen manufacturer Zeneca (an ICI sub-division), issue warning letters to health care practitioners about the increased risk of endometrial and gastro-intestinal cancers with tamoxifen use. Zeneca also reported adverse effects similar to those seen with DES, such as reproductive abnormalities in the animals whose mothers received tamoxifen. (remember, DES was the original synthetic estrogen, and also an analog to tamoxifen)
A number of cancer researchers have pointed out the health risks too, such as Elwood et al (6) -
“[Tamoxifen], therefore, is not appropriate for use in the general population because of the known increased risk of endometrial cancer”
What Are Side Effects Of Temoxifen
You Can Get Blood Clots!
Have you any idea that a regular dosage of Tamoxifen can actually increase the chances of blood clots? Well, this is a true fact and can be fatal for those who are using this drug to get rid or avoid the chance of getting Gyno on cycle and or for post cycle therapy (pct). According to recent medical studies, it has been noticed that people who have been using Tamoxifen on a regular basis have had a substantial increase in terms of their blood clots. Hence, as compared to those people who are not using this drug, their chances of getting blood clots is relatively higher.
A blood clot can be defined as an internal body mechanism by which the cut can be stopped from bleeding excessively. The proteins present in your blood work along with the platelets and in a bid to form a clot. This is also termed as coagulation. In the event of an injury, this can prove to be really very effective as it would stop the flow of blood from your wound and thus save your life. Nonetheless, if the blood clots while it is moving through your body, it can prove fatal. This is also termed as hyper coagulation and it can prove very dangerous for the concerned individual. Tamoxifen has been known to cause hyper coagulation and hence, it needs to be taken under strict medical supervision.
When the study was conducted, it was ascertained that a relatively large number of people developed this conditions and although not many people using this drug were actually studied, those that were using it regularly, were in a shock to find out that it also led to blood clots.
Hence, although this drug is helpful to a certain extent, we need to also see that the extent of damage it can do to our body in terms of hazardous blood clots are much more and hence, you as a steroid user need to exercise caution and spend some quality time researching on this so called ‘wonder-drug’ before making it an eminent part of your daily routine and or post cycle therapy (pct).
One of the main reasons why a blood clot is considered dangerous is because this drug causes a clot inside the blood vessel which in turn is known as thrombus. What happens is that at times this blood clot can travel through your blood streams and get pushed into your lungs. When this happens, you can be rest assured that your life is in acute danger as this condition is life threatening. This condition is also known as pulmonary embolus. Similarly, a clot this clot can also block the blood vessels in the brain and this in turn may lead to a stroke. When this blood clot clocks the blood vessels of your heart, it stops the blood from rushing to your heart area thereby reducing the oxygen supply to that area. This in turn leads to cardiac arrest.
All the above mentioned conditions arising from blood clots, which in turn are caused from a regular intake of Tamoxifen, can prove to be life threatening for the concerned individual. Hence, even before you decide to take this medication on a regular basis, you need to exercise caution and be prepared to face the ill effects of this so called ‘wonder-drug’.
Increased susceptibility to gyno -
Tamoxifen is often used to combat gyno during cycle when “flare ups” occur. While tamoxifen may provide immediate inhibition of proliferation, and serve as valuable tool, it can actually increase future susceptibility to gyno.
This is caused by tamoxifen’s ability to up-regulate the progesterone receptor. (54-56) This can dramatically increase the chances of developing gyno in future cycles when utilizing progestin based anabolics such as Nandrolone (Deca) or Trenbolone (or any pro-hormone acting upon the progesterone receptor).
It is interesting to speculate. Is tamoxifen use directly related to the increased gyno occurrences seen with modern day steroid users?
You Can Develop Cataract!
Cataract can be defined as a thin white layer of membrane which blocks the passing light to the retina thereby clouding your vision. Although it is relatively painless, it does cloud your vision and can even blind you if it is not removed through the means of a surgical procedure. The retina is ideally a nerve layer which is located at the back of the eye socket and its main purpose is to direct the light which is entering the eye via the means of electromagnetic signals to the brain. Once the brain receives these nerve signals, it is passed on to the nervous system, after which you can transform your vision into clear moving pictures. If this thin layer of membrane is blocked owing to any reason, you would have problems with your vision.
While aging is looked on as the major cause behind cataract, it has recently been noticed that patients using Tamoxifen have been identified as ones susceptible to cataract on a regular basis. people who are aging and using this drug on a regular basis are on a higher risk of contracting cataract as compared to those who are not using Tamoxifen. The other eye problems that can be faced by individuals include scarring of the corneal area and abrupt retinal changes.
In case you are using this drug regularly and you have a cloudy, fuzzy or foggy vision, you need to get your eyesight checked with immediate effect. In case you are unable to withstand the glare of lamps and are unable to catch a glimpse of the morning sun, then again you need to get your eyes checked. This is so because, Temoxifen has a natural tendency to obstruct the normal eye vision and if you do suffer from this symptom, you may not be able to drive at night as the headlamps of the opposing vehicle may blind you momentarily.
In order to get rid of cataract that has been developed owing to a continuous intake of Temoxifen, you may need to undergo a corrective surgery. In case you want to delay a surgical procedure, you may want to light up your room with plenty of tubes and bulbs and keep your eyeglass up to date with the latest prescription. Ideally, the only known cure for cataract that has been a resultant of Temoxifen is a surgical procedure.
If you would like to avoid this problem, you would have to seek an alternative to Temoxifen at the earliest given opportunity.
Libido reduction & erectile dysfunction
Erectile dysfunction ow libido, and general impotence are typical complaints from men recently discontinuing steroids or HRT therapy, which is often combated by Clomid or Nolvadex, paradoxically so.
Regardless of any positive effects on fertility or testosterone levels, Clomid and Nolvadex use is highly correlated with erectile dysfunction, libido suppression, and even emotional disorders Research with male breast cancer patients has also reported decreased libido, and thrombosis associated with tamoxifen use. he thrombotic effect (blood vessel clogging) could explain the mechanism by which SERMs may inhibit erectile function, by reducing circulation to erectile tissue (as discussed before)
Nolva/clomid both raise shbg.
This is something I do not see a lot of people disusing so I I wanted to make it well know. Just do a web search on TAMOXIFEN,clomid or nolva raises shbg or any variation and you will get all the studies and prof you need.
Trait Anxiety and Tamoxifen Effects on Bone Mineral Density and Sex Hormone- Binding Globulin -- Cameron et al. 64 (4): 612 -- Psychosomatic Medicine
iHOP - Information Hyperlinked over Proteins [ SHBG ]
Sex Hormone Binding Globulin in Clinical Perspective; Acta Obstetricia et Gynecologica Scandinavica - 66(3)
ages 255-262 - Informa HealthcareWiley InterScience :: Session Cookies
2. Nolva lowers Igf-1 Again just a simple search on (TAMOXIFEN or nolva lowers IGF 1 and walla you got all the prof you need.
In This Issue -- 82 (21): 1661 -- JNCI Journal of the National Cancer Institute
http://cancerres.aacrjournals.org/cgi/reprint/49/7/1882.pdf
Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women
Comparison of Tamoxifen and Testosterone Propionate in Male Rats: Differential Prevention of Orchidectomy Effects on Sex Organs, Bone Mass, Growth, and the Growth Hormone-IGF-I Axis -- Fitts et al. 25 (4): 523 -- Journal of Andrology
They can cause Major triglyceride and glucose problems and even to the point of Severe hypertriglyceridemia or also Pancreatitis
Severe hypertriglyceridemia caused by tamoxifen-tr... [Endocr J. 1997] - PubMed result
Tamoxifen-induced hypertriglyceridemia in association with diabetes mellitus - EM|consulte
SpringerLink - Journal Article
Capecitabine-Induced Severe Hypertriglyceridemia: Report of Two Cases -- Kurt et al. 40 (2): 328 -- The Annals of Pharmacotherapy
Elsevier: Article Locator
Estrogen and Triglycerides
http://annonc.oxfordjournals.org/cgi/reprint/11/8/1067.pdf
WikiGenes - Hypertriglyceridemia
A word on clomiphene (Clomid) –
Clomiphene (Clomid) consists of two stereoisomers which possess radically different pharmacodynamics. Zuclomiphene has predominantly estrogenic effects and slow clearance while the enclomiphene isomer has predominately anti-estrogenic effects and quick clearance. his creates a divergent effects between estrogen blockage and estrogen stimulation and an acute imbalance once Clomid administration is discontinued. Bodybuilders will often complain of “estrogenic rebound” after stopping Clomid, which could be attributed to the lingering estrogenic isomer zuclomiphene as the anti-estrogenic enclomiphene has long cleared the system. (Recently, enclomiphene has been isolated by the pharmaceutical company Repros, for use in Androxal™.)
For all intents and purposes, tamoxifen is a superior SERM, simply for the fact that tamoxifen provides a purely anti-estrogenic isomer, whereas Clomid provides a mix of anti and pro estrogenic effects.
In regards to the health consequences about to be listed, it can be safely assumed that Clomid will share similar detrimental effects as tamoxifen, since it shares the same triphenylethylene backbone and carcinogenic tendencies.
One of the main reasons why people make use of Clomid is for the purpose of recovering their bodies after a steroid cycle In simple words, this drug is mainly used in the form of post cycle therapy. Clomid has the actual potential to stimulate the production of hypothalamus which in turn would release a particular kind of hormone called gonadotrophic hormones. This hormone has the natural ability to allow the human testicles to secrete testosterone, which in turn would bring the depleting levels of testosterone in the body to its permissible levels. When this is achieved, the human body would stop losing its muscle mass in a natural way. Reacovery of test production is the gaols at any cost is the common thought.
Its a known fact that both clomid and nolvadex cause some really messed up mood swings.
Clomid/nolva have been known to cause severe mood swings in users and it has apparently been noticed that anyone who has been making use of Clomid/nolva have suffered from such side effects on a regular basis. Many users have categorically complained that the use of Clomid has been considered as the worst side effect that they have suffered so far. A few features of mood swings may include a change in the usual behaviour, tearful behaviour, excessive depression, anxiety and extremely sensitive in nature. Stop acting like you don't know what I am talking about. We all know its true.
Liver cancer -
Originally, tamoxifen was accepted as being non-toxic to the human liver upon finding that tamoxifen did not cause noticeable liver damage (DNA adducts) during short-term test tube studies with human liver cells.
However, it became apparent that test tube research was largely flawed due to the low rate of metabolism in such a superficial environment. It was soon discovered that the hepatotoxic effects from tamoxifen stem from the metabolism and buildup of the a-hydroxytamoxifen and N-desmethyltamoxifen metabolites, which would only appear in an in vivo environment. Surely enough, the results from the original rat studies showing dramatic carcinogenic effects on the liver, soon correlated with human data when researchers found the same type of liver DNA adducts in tamoxifen patients.
More recent human research has reported tamoxifen treated women to have 3x the risk of developing fatty liver disease, which occurs as soon as 3 months into therapy at only 20mg/day. In some cases, the disease lasts up to 3 years, despite cessation of tamoxifen therapy. Five and ten year follow-ups with patients on long term tamoxifen therapy show cases of deadly hepatocellular carcinoma.
In 2002, a bizarre study examined the use of tamoxifen for hepatocellular carcinoma treatment in humans. It was assumed that since tamoxifen could inhibit proliferation of breast cancer, it could offer the same benefit for liver cancer. The devastating results could not have been more indicative of tamoxifen’s hepatotoxic nature, as the tamoxifen treatment significantly increased the rate of death, compared to the group not receiving tamoxifen.
Finally, in a case study reviewing tamoxifen induced liver disease; D.F Moffat et al made a profound statement –
“Hepatocellular carcinoma in tamoxifen treated patients may be under-reported since there may be reluctance to biopsy liver tumours which are assumed to be secondary carcinoma of the breast.” In other words, it appears that liver carcinomas from a large number of breast cancer patients on tamoxifen therapy have been misdiagnosed as an infection from the breast cancer itself.
Although tamoxifen induced liver cancer may take years to manifest in a healthy male, its damaging effects could easily be exaggerated by other popular hepatotoxic drugs, such as 17aa oral steroids.
And to finish it off does nolva or clomid help with any of the following ( things you lose when you come off steroids)
1. Nitrogen retention and protein and carbohydrate synthesis.
It is a well known fact steroids promote nitrogen retention in the muscles. The more nitrogen the muscles holds the more protein the muscle stores, and the bigger the muscle gets.
Steroids also increase carbohydrate synthesis. More of what you eat is used as muscle fuel and energy.
2. Euphoria, heightened self-esteem and aggression.
This ones some what self explanatory. You feel like king of the world and life just seems great no matter what happens. Yet the moment you step into the gym you turn into a beast and kill everything in site!
3. Blood quality,blood volume, and muscle gorging pumps.
Ever notice how quickly the muscle gets full when training on steroids and designer supplements? How you feel like your muscles are going to rip out of your shirt and your veins are going to pop out of your skin? That's enriched blood and blood volume.
Ya Not even going to touch this with colmid or nolva.
4. Libido,extreme sexual urges, hard erections.
Of course this can be tied in some what to recovery of the hpta but not completely.
HMMM maybe and I big maybe. For the most part most people feel like crap on nolva and clomid and sex drive is almost always in the shitter well on them
5. Strength, stamina, and muscle recovery.
Oh yes the pounds keep adding up on the bar and we keep pushing out the extra reps. Over and over we kill it in the gym and wake up the next day ready to kill it again.
Not a chance in hell of them helping with this!!!
Read this too.
Health and fitness articles: Clomid & Nolvadex Toxic Side Effects Exposed
I am not totally against the use of them but why use them if you do not "NEED THEM"
use them when they are needed for the reasons they are needed. However phytosrms are real and they do work. Phytoserm - Wikipedia, the free encyclopedia
Lots of other things work perfectly fine for post cycle therapy (pct).
The foolish notion that the "only" thing that work for post cycle therapy (pct) is a nolvadex and or clomid is just that...foolish. But that is just my stance on the matter.
May I also point out that I have not said that they do not work for post cycle therapy (pct). Because they do. I just do not like tham, never have, and never will no matter what. I have been this way for many many many years. I can date my first post of disdain for them all the way back to 2006 on other forums. I started NTBM in 2009. So no it is not because I have a supplement company.
Needtogetaas
Official Sponsor
But everyone else is right though. Get rid of the gyno first before you do a cycle. Although You can run effective gyno reduction cycles.
nolvadex+provirone+aromasin is a good one that lots of people like. Epi-strong is not documented enough to fuck around with it when dealing with gyno problems.
nolvadex+provirone+aromasin is a good one that lots of people like. Epi-strong is not documented enough to fuck around with it when dealing with gyno problems.
Needtogetaas
Official Sponsor
You can read this. THen you can pm me if you like or anyone else can do the same too.
Over the last 4-5 years there has been one subject people have come to me for help with over ans over again. One subject and one problem that every man fears and no man wishes on even there worst enemy. Gyno is a horrible horrible thing to deal with. It can ruin your life, rob you of confidence and change the way you look, act, and feel about your self. Often it leaves people feeling hopeless if they can not get rid of gyno right away and then surgery seems to be the only option they have to turn to.
Gyno surgery is not a cheap option though. It can cost not only thousands of dollars but life long problems and side effects. A messed up surgery job can never be fixed and once its done you are stuck with it.
Thankfully we have advanced and many of us are starting to learn that in time almost any if not all gyno can be cured with out surgery. Some times it may only take a month or two but for others it can take up to a year. However all gyno can be cured with the right combination of drugs,products, and cycles.
The main problem is no one knows how, or is willing to trust another to show them. Well for years now I have been helping thousands of people with gyno and I am happy about what I do. I do not charge for it because I feel charging a man when he is down like that is immoral and wrong. So I offer my service free of charge to hundreds of people a day when I have the time ( I always find the time). My friends some of the info in this Article may seem jumbled or even hard to understand to many. Try and read everything and understand what you can. In the end just remember I am always here to help you and you can ask me anything you like, Send me a pm, a email, or even call me any time I am always here to help a fellow friend or brother in Iron.
Just because you think I am to busy, or because you do not know me very well yet is no reason not to contact me. I am here to serve the members of this forum and all people who need help. This is no laughing matter and some people out there need serous help. That is why I am here!!!! :biggrin: I assure you that your gyno ( any kind) can be prevented and or cured. Do not believe the hype that the only way is surgery
First before we can understand how to combat and deal with gyno we must first have a better understanding of the hormones involved with creating gyno. What they are, what they do, and even where they come from.
What is Estrogen?
Estrogen hormones are vital to the estrous cycle, and function as the primary female sex hormone. It also contains neuro-stimulative properties which is why too much estrogen can cause anxiety. Estrogen is synthesized in all vertebrate mammals as well as certain insects. The existence of these steroid hormones in both mammals and insects conveys that estrogenic sex hormones have an antique evolutionary account.
E1 (good estrogen plays a role in bone formation and bone preservation. Estrogen does also play a role in preservation of cholesterol through increasing High Density Lipoprotein levels and lowering Low Density Lipoprotein levels. Estrogen also allows for healthy looking skin since it increases the production rate of melanin which explains why women are so pretty! Just take a look at Marilyn Monroe the perfect example of a beautiful bottle shaped women with plenty of estradiol. Estrogen also keeps women in a better mood, specifically estradiol.
Unfortunately, Estrogen (E2) also plays a role in initiating prostate/breast cancer. Estrogen also aggravates blood platelet aggression which could lead to a severe blood clot, which leads to a stroke or heart attack/heart disease. Estrogen decreases fecal matter motility which leads to constipation. Estrogen also leads to loss of muscle mass and gains of fat deposits within the adipose tissues. Estrogen also leads to an increase in cortisol levels along with a rise in SHBG's. This quickly will lead to a DROP IN TESTOSTERONE! In theory, this could explain why steroid user's testosterone levels do not come back 100% percent with when usinga SERM alone for post cycle therapy (pct)!! there is documentation showing that Selective Estrogen Modulators raise SHBG levels as well as studies that show they " raise not lower" estrogen levels.
There are other sources of estrogen as well; the other common types are xenoestrogens, mycoestrogens, and phytoestrogens.
These are outside sources of estrogen and we encounter them every day of our lives. often they are the cause for pubertal gyno a grossly growing problem around the world.
Xenoestrogens are chemically produced compounds that have estrogenic effects and differ chemically from naturally occurring estrogenic substances such as female estrogen hormones. As a heterogeneous group of chemicals that are hormonally living compounds. Xenoestrogens show similarity to other estrogens such as phytoestrogens and mycoestrogens. Xenoestrogens also have pharmacological estrogens (estrogenic action is an intended effect, as in the contraceptive pill), but of course other chemicals can too have estrogenic effects. Xenoestrogens have been presented to the environment by industrial, agricultural, chemical companies and consumers only in the last 70 years give or take. However; archiestrogens have been a omnipresent part of the environment even prior to the existence of the human race. There is evidence that shows xenoestrogens create oncogenes by overstimulating proto-oncogenes. When an oncogene is highly stimulated it becomes a tumor cell which we all know is bad news. There is significant evidence in a variety of recent studies linking xenoestrogens to the onset of breast cancer by an increase in breast cancer growth within in the tissue of the mammary. Xenoestrogen exposure has shown to be a reason why boys have delayed pubertal onrises, these xenoestrogens have also been linked to giving pubertal boys gynecomastia or also known as GYNO. Gyno does not look appealing can really lower a young man or adult's self esteem. Gyno makes the difference of someone not being able to take of the shirt at the beach because of the fear that someone may make them feel less of a man by pointing out the gyno on his chest. (Pediatrics. 2003 Jul;112(1 Pt 2):247-52.) Xenoestrogen exposure and consumption has also been linked to testicular atrophy and reduction of gondal size. This issue leads to a hault in spermatogenesis, reproductive problems, barely or no sperm motility, an increase in estrogen to testosterone ratio which leads to the cessation of testosterone production, all these issues become VERY problematic to the HPTA.
One well known Xenoestrogen is BPA; which is known to dramatically decrease DNA methylation by increasing hypomethylation. This causes a sudden rise in estrogens which causes problems to the male endocrine system. Bisphenol A functions as a xenoestrogen by binding STRONGLY to estrogen-related receptor ***947; (ERR-***947. This unidentified ligand behaves as a constitutive activator of transcription. BPA seems to bind strongly to ERR-***947; (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER). BPA binds to the ERR-***947; to preserve its basal constitutive activity. (J Biochem. 2007 Oct;142(4):517-24. Epub 2007 Aug 30.) BPA has also been linked to an increase in prostate size and aggrevating prostate cancer. Another study displayed how BPA is an estrogen agonist and causes PERMANENT growth in the prostate, in other words its irreversible which is NOT GOOD! Exogenous estrogen was also shown to be the culprit in permanent growth of the prostate. Just a heads up, BPA is what a lot of companies use to make their plastic, many coming from plastic bottles. You might want to give your kids more Brita or filtered water instead of plastic bottles to avoid exposure to BPA. Another option would be to avoid canned foods with their notoriety of containing BPA. The scary fact is that it does not have to be much BPA exposure in order to cause all these affects, which something people should really analyze. BPA has also been linked to causing a drop in dopamine which leads to a LOSS IN LIBIDO and a drop in memory, in other words, an aging brain. BPA has also been shown to have negative effects on the thyroids which can be detrimental to fat loss and the homeostasis of the body. I have seen people have such drastic weight fluctuations due to their thyroid malfunction condition. (Journal Of Health Science. Vol. 55 (2009), No. 2. 147-160).
Nonylphenol is of the organic compounds which are subsets of the alkylphenols. Nonylphenol is a useful precursor to certain detergents/laundry detergents. They are even used in contraceptives and condoms, really scary stuff indeed. Nonylphenol is considered to be an endocrine disruptor due to frail ability to mimic estrogen and in turn; disrupt the HPTA of the male endocrine system. The effects of nonylphenol is not as potent as other Xenoestrogens because nonylphenols are not very close structural mimics of estradiol, but the levels of nonylphenol can be sufficiently high to cause damage to the male endocrine system. Nonylphenol has been commonly detected in waste water streams across the world, which is a problem since we wash our clothes with that same water. For example, nonylphenol has been detected both in the Great Lakes and in the region of New York City. Nonylphenol is persistent in the environment, therefore lingers with the potential to negatively affect the humans and of course males endocrine systems. Nonylphenol also accumulates overtime, which is dangerous to those who eat meat, another reason why people should very conscious of where they buy their meat from.
Parabens are found in lotions and also known to be xenoestrogens with pro-breast cancer activity. However it is one of the weaker forms of xenoestrogens.
There is some evidence suggesting that the food preservative BHA is also a xenoestrogen, California has already made it a policy to label BHA as a carcinogen.
DDT which is a WELL KNOWN insecticide has also a xenoestrogen has been touted as an endocrine distributor because of its negative effects on semen quality. It's a highly estrogenic component that causes a decline in testosterone. There is research that shows that DDE a metabolite of DDT acts as anti-androgen. This means that one will feel and act less like a man when exposed to it, ranging from a lack of libido to being a straight up wimp. DDT has also been linked to causing increased risks of diabetes and also provoking a lack of function within the thyroid hormones. They have also linked DDT to testicular cancer, which is more proof for how destructive this xenoestrogen is to the endocrine system. DDT is also linked to breast cancer but that is pretty obvious since it is a XENOESTROGEN.
As you can see Xenoestrogens range from sunscreen lotion to women's cosmetics, this lets you know that our endocrine system is threatened everyday just by our environment alone.
My friends the odds are stacked against us, and it does not end here.
Phytoestrogens
Phytoestrogens also known as "dietary estrogens", are a varied group of naturally occurring non-steroidal plant compounds that share of their similar structure with estradiol, and have the ability to cause estrogenic much more often than anti-estrogenic effects. Phytoestrogens primarily belong to a large group of substituted polyphenolic compounds; which comprise of the coumestans, prenylated flavonoids (the hobs you find in beer) and isoflavones (soybean are genistein and daidzein which are all bad for the endocrine system) are three of the most active in estrogenic effects in this class. The most researched and documented are the isoflavones, which are normally found in soy and red clover. Lignans have also been identified as phytoestrogens, although they are not flavonoids. Mycoestrogens have comparable structures and effects, but are not related to plants; they are mold metabolites of Fusarium. Phytoestrogens exert their effects mostly through binding to estrogen receptors (ER). There are two variants of the estrogen receptor, alpha (ER-***945 and beta (ER-***946 and numerous phytoestrogens display fairly higher affinity for ER-***946; compared to ER-***945;. Besides the interaction with estrogen receptors, phytoestrogens can also modulate the concentration of endogenous estrogen hormones by binding or ceasing efficiency of some enzymes, and this could affect the bioavailability of sex hormones by binding or stimulating the synthesis of sex hormone binding globuline. Foods with the highest relative phytoestrogen content were nuts and oilseeds, followed by soy products, cereals and breads, legumes, meat products, and other processed foods that may contain soy, vegetables, fruits, alcoholic, and nonalcoholic beverages. Flax seed and other oilseeds contained the highest total phytoestrogen content, followed by soybeans and tofu. The highest concentrations of isoflavones are found in soybeans and soybean products followed by legumes, whereas lignans are the primary source of phytoestrogens found in nuts and oilseeds (e.g. flax) and also found in cereals, legumes, fruits and vegetables.
Phytoestrogen concentration varies in diverse foods, and can contrast significantly within the same group of foods depending on processing mechanisms and the type of soybean extract used. Legumes, whole grain cereals, and several seeds are high in phytoestrogens. A more broad list of foods known to have phytoestrogens includes: soybeans, tofu, soy beverages, flax, sesame seeds, barley, dried beans, lentils, apples, carrots, pomegranates, wheatberries, oats, wheat germ, rice bran, soy linseed bread, ginseng, hops bourbon, beer, fennel yams, rice, alfalfa, mung beans and anise.
There has been an increase in reports about incidences of male reproductive abnormalities and falling sperm counts have driven interest into the nature of these threats to worldwide fertility. Xenoestrogens have been flagged as major culprits. These non-steroidal estrogens/oestrogens of plant derivation are potent endocrine disruptors that modulate normal physiological functions. Phytoestrogens have also become a major factor in the usual Western fast food diet over the last few decades. Soy formula milk is another widespread source of phytoestrogens, now used increasingly as an alternative to breast or cow's milk for infants with allergies. This use is of a HUGE concern since the most vulnerable periods for oestrogenic abuse are thought to be the pre- and neonatal periods when almost irreversible harm can be brought onto the developing child. Studies concerning the safety of phytoestrogens are now needed either to relieve fears or increase awareness of the effects of our current diet on potential fertility. (2005, Vol. 8, No. 3 , Pages 197-207 (doi:10.1080/14647270500030266)).
Phytoestrogens don't even provide benefit in women
A HEALTHY women post menopausal consumes less than 1mg of phytoestrogens, which is pretty much nothing. There was a study conducted with 964 postmenopausal Caucasian women who participated in the Framingham Offspring Study and completed the Willett food-frequency questionnaire (FFQ). By searching the agricultural and medical literature, they were able to identify food sources of phytoestrogens. The concentrations of the diverse isoflavones, coumestrol and lignans in each food in the FFQ were scored in seven categories, then multiplied by the serving size of the food, and the frequency of its expenditure. The estimated daily median intake of the isoflavone daidzein was 39 microg (24-57 microg); of genistein, 70 microg (28-120 microg); of formononetin, 31 microg (13-44 microg); and of biochanin A, 6 microg (2-11 microg). Median total intake of isoflavones was 154 microg (99-235 microg). The main sources of isoflavones were peas and soy beans. The estimated daily intake of coumestans was 0.6 microg (0.2-1.7 microg), with broccoli as the key source. The estimated daily median intake of matairesinol was 19 microg (12-28 microg) and of secoisolariciresinol 560 microg (399-778 microg). The median total intake of lignans was 578 microg (416-796 microg). The main source of the lignans was fruits. (J Nutr. 2001 Jun;131(6):1826-32.)
As you see from the information above, one serving alone of these phytoestrogens can be detrimental to women's health over a period of time. Even more so to a man!
Phytoestrogens have also been linked to immunosuppressive effects along a decrease in thyroid output function. These studies that linked phytoestrogens to immunodeficiency showed how consumption of SOY isoflavone and genistein lowered t-cells which we know is something that occurs usually in HIV/AIDS patients. HIV/AIDS is a diease which causes one's immune system to shut down completely allowing one to catch any disease.
Estrogen is all around us; it is well known that the estradiol level in 55-year old men, for example, is usually a bit higher than that of a 55-year old woman. Unfortunately after the age of the 30, men's testosterone levels continue to plummet 10 percent every 10 years. Many factors lead to estrogen dominance ranging from life stress to the xenoestrogens we consume. A man, however, does not develop breasts because he has a higher testosterone level than women do and a lower estrogen ( the world is changing this).
As men age, their estradiol levels gradually rise, whereas their progesterone and testosterone levels gradually fall. The hormone balance changes. These gradual changes lead to reduction in testosterone benefits and eventually to estrogen dominance.
That is, a mans estradiol effects emerge since his testosterone level is not sufficient to block or balance out the Estrogen. The Estrogen Dominance then stimulates breast cell and prostate hypertrophy. Estrogen Dominance is responsible for the majority of breast cancers and is the only known cause of endometrial cancer in women. Since the male prostate is pretty much the equivalent of the uterus, it should not be unexpected that estrogen dominance is also a major cause of prostate cancer as stated before.
In today's world estrogen dominance is accruing at a much younger age and at a much faster rate. Even for much younger when when estrogen is not completely dominant the much higher levels of estrogen is still causing life long problems.
Estrogen dominance is a growing health concern for Men all over the world. Although it is more common in older men. It is quickly becoming a epidemic in younger men causing such problems as infertility, erectile dysfunction, enlarged prostate, and certain types of cancer. Many of the symptoms can be seen in our youth today. Many of the symptoms you may even notice in your own life.
The symptoms of estrogen dominance in men include:
Low sex drive
Impotency/erectile dysfunction
Infertility
Male pattern baldness
Gynecomastia, or "man boobs"
Weight gain
Enlarged prostate
Prostate cancer
Testicular cancer
mood swings
and many many more.
Symptoms of the on set of gyno
puffy nips
Itchy and or sore nips
lactating or fluid from the nipples
Pain to the touch
Gynecomestia
In adolescent boys, the condition is often a source of distress, but for the large majority of boys whose pubescent gynecomastia is not caused by obesity, usually the breast enlargement shrinks or disappears within several years. The condition is usually caused by an imbalance of estrogenic to androgenic (usually estradiol to testosterone ratio) effects on the breast tissue, resulting in a surge of unconstrained estrogen action on breast tissue. Approximately only 4 to 10% cases of gynecomastia are due to drugs. The aromatization takes place in the cyto-chrome enzyme P-450. Both Digoxin and Furosemide are drugs reported to cause the gyno as well, however; anabolic androgenic steroids are the most common drugs in causing gynecomastia. Breast prominence can result from hypertrophy of the breast tissue, chest adipose tissue (fat) and skin, and is normally a combination of the two. Breast distinction due exclusively to too much adipose is often termed pseudogynecomastia aka psedogyno or sometimes lipomastia.
Types of Gynecomastia
Puffy Nips: is one of the more common forms of gynecomastia. This glandular tissue buildup is concentrated under and in general confined to the areola, however; it can be slightly extended outside the areola forming a dome shaped image to the areola.
Glandular: This form of gyno is common with bodybuilders as a result of the use of anabolic androgenic steroids. The undeniable overload testosterone levels from AAS (specifically any form of test) are converted to estrogen via aromatization. Bodybuilders and along other athletes are afflicted with gynecomastia in its purest form when suffering from AAS gyno. However; drug-induced gynecomastia can almost be resolves with the use of proper supplementation, if caught before permanent fibrosis develops and even after it can still be cured.
Gynecomastia in lean men is generally only a breast tissue gland with no added adipose tissue; heavier men will have sloppier looking gyno because of the adipose tissue covering the glandular tissue. Guaranteed treatment of pure gynecomastia can be done simply by removal of the breast tissue, which also rids of the gyno tissue. Most of the time the glandular tissue is benign but at times it can become malignant, so gyno is NO laughing matter and must be taken serious especially during or after a cycle. So good bro's make sure you keep an eye out on your chest during cycle and take good care of yourself during and post cycle. Again I must stress that any and almost all gyno can be treated with out surgery but in some cases it is better to take care of it sooner rather then later.
Adolescent/Pubertal Gynecomastia: The Congenital or Hereditary Gynecomastia is on average evident by the ages of 9 to 18 in young males. About thirty percent to sixty percent of young adolescent boys experience pubertal gynecomastia. UNFORTUNATELY, thirty percent possibly will live with enlarged male breasts for the rest of their lives, but in other cases the gynecomastia will go away with age. However, severe forms of adolescent gynecomastia may require an involvement, in conference with the patient, the parents, and child development professionals. Now of course there is hope for men who have lived with gyno all of there lives. Your parents may have neglected it but there is no reason you have to.
Adult or andropause gyno: This is the most common form of gynecomastia due to declining androgen levels with a rise in estrogen in elderly or post andropause men. Gynecomastia based off of post andropause in most adults is composed mainly of glandular tissue but it may contain varying amounts of adipose and tough tissue. Now you know why old men have those wrinkly chests that look like they never had the shape of pecs on them before.
Asymmetric/Unilateral: Unilateral gynecomastia occurs when only one breast is bigger due to a case of gynecomastia. The other breast is usually normal in size and shape. Bilateral Asymmetry occurs when gynecomastia is present in both breasts, of course; each being to a different degree. Most bodybuilders and boys during puberty acquire unilateral gyno, and by a pretty big margin I might add.
Severe gynecomastia: is described as an excess or loose skin, and severely enlarged breasts. This form of gyno is determined in part by age, reason being older people suffering from gynecomastia tend to have less skin elasticity and therefore will have a greater profusion of excess skin associated to gynecomastia. Experienced plastic surgeons will perform as much of the surgical treatment of severe gynecomastia as feasible through an aereolar incision so as to avoid widespread scarring. However, some scarring may be inevitable when treating severe cases of gynecomastia. The larger the gyno the more the scaring and this is why even if you are going to have surgery once should try to reduce gyno in size as much as possible beforehand
Pseudogynecomastia: is not composed of glandular tissue, but rather of adipose tissue (fat). It looks a lot like typical gynecomastia but requires different treatment. Exercise and diet can be very effective in preventing and fighting off pseudogynecomastia. Only if this regimen is unsuccessful should surgery be considered an option. This is generally the only type of gynecomastia which can be improved with liposuction, but removal may be used in some cases as well. This form of gyno is also known as "false Gynecomastia" and is often associated with obesity whereby insulin interacts with a surplus of sugars or certain carbohydrates, specifically those of which that have been processed.
Not just estrogen causes gyno!!
PROGESTERONE. IGF, GH, AND PROLACTIN INDUCED GYNECOMASTIA
Gynecomastia can be as a result of a number of agents including estrogens, progestins, GH, IGF-1, and prolactin may all be involved. Regarding prolactin, androgens decrease prolactin levels while estrogens increase prolactin. Non-aromatizing androgens such as DHT have by no means been shown to raise prolactin levels in humans, but testosterone has, due to its aromatization to estradiol. Prolactin secreting tumors also known as prolactinomas, are often linked with gyno. Of course in these cases the prolactin is believed to induce gyno by suppressing testosterone production. Prolactinomas that are adequately large to cause gynecomastia, do cause gyno as a consequence of the impairment of Gonadotropin secretion, which leads to secondary hypogonadism. Remember Prolactin only has a direct effect on breast tissue only when estrogen is present so they say ( how much is needed?). This is why they say lowering estrogen levels will lead to lower prolactin levels and then eventually less occupied progesterone receptors. Keep in mind just using something to lower estrogen will not cure gyno when progesteonr/prolactin is one of the culprits. Also take into consideration that as IGF and GH levels rise, they will also rise within the mammary glands which could cause a growth of glandular tissue if the rise in IGF and GH is too rapid. This in basic terms means you got the GYNO.
After awhile, excess levels of prolactin also lead to laction which is when the mammary gland secretes milk. I don't know about you my friend but milk coming from my nips just is not something I want to experience. And I have no plans to feed young children even my own. Secretion is not the only way of knowing your gyno is of progesterone/prolactin nature but it is one clear indicator.
Aromatizing AAS
There are AAS that are more likely to induce gynecomastia whether it be due to aromatization or aromatization with progesterone site binding. Here is a small/general list of the more common and moderate to high aromatizing compounds.
Any form of Testosterone
Dianabol
Deca Durabolin/nanodrolone (progesterone)
MethylTestosterone
Methyltrienolone
Any form of Trenbolone (progesterone)and androgenic
Anadrol 50 Receptor cross over
Nondrolone Laurate (progesterone)
Norethandrolone
M 1,4ad
13-ethyl-3-methoxy-gona-2,5(10)-dien-17-one (progesterone)
2a, 17a-dimethyl-etiocholan-3-one-17b-ol
13 ethyl 3 methoxy
4-ad
Many people have reported receiving gyno from Superdrol, people question those accusations since superdrol is a 5aReduced compound, however; Professor Filimanov the formulator of Need2Slin.
" Prolactin is normaly caused by progestins, but can also be caused by dht, how?
For example, it is currently understood that when testosterone enters the cell cytoplasm it is subsequently converted to the more "active" androgen, dihydrotestosterone, DHT, by reduction at the 5alpha position, this is normal. Dihydrotestosterone is then either bound to a cytoplasmic "receptor" protein Rc, or is further metabolized to either 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol ,DIOL. The binding of DHT to its cytoplasmic receptor protein results in translocation of the steroid-receptor complex into the nucleus where presumably the complex dissociates and DHT exerts its androgenic effects. The transport of DHT to the nucleus can also result from the conversion of testosterone to DHT by nuclear membrane-bound 5alpha-reductase. Prolactin augmentation of DHT effects is envisioned as resulting from interaction of prolactin with its receptor, which due to the large size of the prolactin molecule is probably located in or on the plasma membrane.
Because superdrol is androgenic, but lacks the ability to show affinity via 5ar, it circulates, and this causes the large amounts of androgens to look for a transporter, so that it can bind to the androgen receptor, so it uses prolactin which has a high affinity to cytoplasmic receptor protein, allowing the androgens, testosterone, to be carried and allowing them to convert to dht, only problem is prolactin hormone or luteotropic hormone is synthesised and secreted by sex binding lactotrope cells in the adenohypophysis (anterior pituitary gland, And this gland now produces more prolactin to help deal with the large amount of testosterone circulating that hasnt bound to the estrogen of androgen receptor, Part of the reason why superdol is so anabolic, So instead of binding to the androgen receptors in the scalp and the prostrate it converts to dht through this unique process, using prolactin to enter the cytoplasmic receptror protein, and allowing it to convert to dht and then bind to the androgen receptors in the muscle, causing its distinct hardening effects, it still can't bind to the scalp or prostrate via 5ar as the form of dht it has converted too doesnt allow for that affinity.
So more prolactin is produced to allow for the superdol to find a receptor ,this excess prolactin triggers a process that fills the breast with milk via a process called lactogenesis, in men however it causes a distinct enlargment of the mammary gland and can even cause a man to lactate.
If superdrol had better binding to the androgen receptor via 5AR then this problem would be prevented, the other thing is that prolactin production can remain elevated for months after a cycle has finished, and once the androgen has been removed, ( the cycle is over) the cytoplasmic receptor proteins have nothing to do other than to allow the prolactin to proceed with its hormonal action within the body, causing the male mammary gland to enlarge ready to produce milk... Hence the REBOUND GYNO, this is why proper post cycle therapy (pct) is needed for superdrol, and the use of something to prevent prolactin."
As you see Professor Filimanov reinstates the correlation between prolactin/progesterone and estrogen which could lead to gyno even with a compound such as Superdrol.
Receptor cross over can also occur. Hormones are keys and your receptors are like locks. What happens is a hormone is ether placed in the body (by an out side source) or it is produced with in the body. This hormone we will call a "key". The hormone then sets out to find a "lock" that it can fit into,turn, and sequentially open up the components inside. To go one step more and make it a little more simple I will explain it like this.
Imagine your receptors as little treasure chest. Inside is chest it a set of instructions. This set of instructions can be a number of things. It can be directions to another chest or a task that must now be carried out. With out something to open the chest the instructions can never be carried out or the next chest found and opened. Following me ?
Some hormones are more like "dummy keys" will call them. They will find a "lock" and set them self into the "Lock hole" but then that is it. They never turn the key and open up whats inside. so we see hormones often work like this
1. Key fits a lock. AKA a hormone found a lock and set its self into it. Pretty simple
2. Key was not a dummy key and when it set its self into the lock it turned and opened up the chest letting out the instructions inside that will now be carried out.
3 "master keys" We will call them. Or "Muti function keys"
A subject not much talked about on any of the steroid forums or even in many articles I have come across is the fact that. In respect to anabolic steroids (out side source of hormones) most of them have all been explained as just "lock" and "key" . However the truth is pro hormones,disginer steroids and steroids all have "Multi function" and some even "Master key" functions.
as you can see explained earlier.
By now I am sure you are confused but that is fine. The body is a extremely complex thing and everyone's body acts the same yet differently when it comes to hormones. This is why a lot of times you must work with some one to help find out what works for you. To help find out more about you and how your body works, as well as the basics of science and how all things "should" work.
This last part has thrown many for a loop. Leaving many wondering why the have gyno when they did everything right, and used all the right compounds. The sad truth is there is no Guarantee that you will not end up with a case of gyno.
However there is one Guarantee and that being that no matter what the odds are on your side that your gyno can be reversed with proper supplementation my friends. You just need to know how. Often it is best to work with some one who has experience and has worked with many others to prevent or reverse gyno of all kinds.
Believe me friends, I know it is NOT easy by any means to feel comfortable about your body when you have gyno whether it be from puberty or AAS usage. It can really make one depressed knowing that their chest is not masculine appealing to the people around them or themselves. I know people who LOW SELF ESTEEM for years because of their pubertal gyno. We as people struggle on a daily basis to fit in whether it be through appearance, social status, or self accomplishment. The people I witnessed getting rid of their gyno, achieved all those forms of greatness and more at least to themselves which is all that matters; since it's your body and your life.
Now Of course it is time for the good part. The part every one has been waiting for. If all gyno can be cured then how?
Well My friends I am sorry to be the one to tell you. Yes there are drugs and products out there that work to reduce estrogen. Yes there are drugs that reduce progesterone and or porlactin. Yes there are serms that block the progesterone receptors. Yes all of these drugs and or supplements can be used to reduce,prevent, and even cure existing gyno.
However anyone out there giving you a cookie cutter gyno removing program is simple trying to do one thing. SELL YOU A PRODUCT/GROUP OF PRODUCTS AND OR DRUGS. Or they are only speaking from experience for what worked for them NOT YOU!!!
How many of you have used a friends advice because it worked for them,only to be disappointed when it does not work for you?
How many of us have tried everything only to find nothing worked? Or have you tried everything?
The fact of the matter is I do not hand out cookie cutter programs because although they may work for some they do not work for everyone. Each person must find out what works for them. Each person must learn how they will react to different products,drugs, and combination thereof.
One person my use nolva and it worked great for them. Another may use it and there gyno gets worse or they have a rebound long after. You must learn to read your body, learn what it is telling you. You must learn how to change things exactly when they need to be changed for you and why.
You must start off by having everything you need before hand. This is the one thing that is the same for everyone. When people make the statement "aaah just get some letro" Or hey man all you need is some arimadex and dostinex you will be fine" These people hardly know what they are talking about most of the time. They know what worked for them, they know what might have worked for others. However the most importent fact they know nothing about is WHAT WORKS FOR YOU AND HOW YOU WILL REACT.
Everyone is always looking for the cheap way out. Or the easy way out. SO often we jump all over the quick easy and cheap advice that is so readily handed out on the aas forums today.
When you are ready to do it right, when you want results, when you are at the end of your rope. Then you will bite the bullet and spend the money to get "everything" you need. A gyno removing program can have side effects and the proper supplements should be taken to counteract them.
When it comes to some causes of gyno you have to understand that it took years of exposure to out side estrogen to cause the problem. It may not be resolved overnight but it can be in the end and I am always here to help you do this.
Feel free to pm me any time my friends I am always here on the forums. :biggrin::biggrin::biggrin:
preventing Gyno of course is another topic in its self. When it comes to on cycle gyno prevention one should always use as little as he can or non at all if he can get away with it.
If you do not need it then do not use it. However always have it on hand IMO.
Many of the drugs known today for gyno prevention all have there pitfalls and some are better then others for different reasons. If prevention is what you are looking for then forma-stanzol happens to be the best choice for many different reasons. You can read more about this compound here in this thread. What is the overall best? Best steroid, best post cycle therapy (pct), best gyno treatment
5 to 10 pumps morning and night is all one would need depending on the dosing of the cycle you are on. Back up plans should always be in place and on hand. One should always have letro and dostinex on hand but never a need to use them unless nothing else works.
During post cycle therapy (pct) often people use just nolva or clomid and neglect that fact that these compounds do nothing to lower estrogen nor do they do anything at all for raised levels of prolactin or progesterone. Forma-stanzol on the other hand does.
Over the last 4-5 years there has been one subject people have come to me for help with over ans over again. One subject and one problem that every man fears and no man wishes on even there worst enemy. Gyno is a horrible horrible thing to deal with. It can ruin your life, rob you of confidence and change the way you look, act, and feel about your self. Often it leaves people feeling hopeless if they can not get rid of gyno right away and then surgery seems to be the only option they have to turn to.
Gyno surgery is not a cheap option though. It can cost not only thousands of dollars but life long problems and side effects. A messed up surgery job can never be fixed and once its done you are stuck with it.
Thankfully we have advanced and many of us are starting to learn that in time almost any if not all gyno can be cured with out surgery. Some times it may only take a month or two but for others it can take up to a year. However all gyno can be cured with the right combination of drugs,products, and cycles.
The main problem is no one knows how, or is willing to trust another to show them. Well for years now I have been helping thousands of people with gyno and I am happy about what I do. I do not charge for it because I feel charging a man when he is down like that is immoral and wrong. So I offer my service free of charge to hundreds of people a day when I have the time ( I always find the time). My friends some of the info in this Article may seem jumbled or even hard to understand to many. Try and read everything and understand what you can. In the end just remember I am always here to help you and you can ask me anything you like, Send me a pm, a email, or even call me any time I am always here to help a fellow friend or brother in Iron.
Just because you think I am to busy, or because you do not know me very well yet is no reason not to contact me. I am here to serve the members of this forum and all people who need help. This is no laughing matter and some people out there need serous help. That is why I am here!!!! :biggrin: I assure you that your gyno ( any kind) can be prevented and or cured. Do not believe the hype that the only way is surgery
First before we can understand how to combat and deal with gyno we must first have a better understanding of the hormones involved with creating gyno. What they are, what they do, and even where they come from.
What is Estrogen?
Estrogen hormones are vital to the estrous cycle, and function as the primary female sex hormone. It also contains neuro-stimulative properties which is why too much estrogen can cause anxiety. Estrogen is synthesized in all vertebrate mammals as well as certain insects. The existence of these steroid hormones in both mammals and insects conveys that estrogenic sex hormones have an antique evolutionary account.
E1 (good estrogen plays a role in bone formation and bone preservation. Estrogen does also play a role in preservation of cholesterol through increasing High Density Lipoprotein levels and lowering Low Density Lipoprotein levels. Estrogen also allows for healthy looking skin since it increases the production rate of melanin which explains why women are so pretty! Just take a look at Marilyn Monroe the perfect example of a beautiful bottle shaped women with plenty of estradiol. Estrogen also keeps women in a better mood, specifically estradiol.
Unfortunately, Estrogen (E2) also plays a role in initiating prostate/breast cancer. Estrogen also aggravates blood platelet aggression which could lead to a severe blood clot, which leads to a stroke or heart attack/heart disease. Estrogen decreases fecal matter motility which leads to constipation. Estrogen also leads to loss of muscle mass and gains of fat deposits within the adipose tissues. Estrogen also leads to an increase in cortisol levels along with a rise in SHBG's. This quickly will lead to a DROP IN TESTOSTERONE! In theory, this could explain why steroid user's testosterone levels do not come back 100% percent with when usinga SERM alone for post cycle therapy (pct)!! there is documentation showing that Selective Estrogen Modulators raise SHBG levels as well as studies that show they " raise not lower" estrogen levels.
There are other sources of estrogen as well; the other common types are xenoestrogens, mycoestrogens, and phytoestrogens.
These are outside sources of estrogen and we encounter them every day of our lives. often they are the cause for pubertal gyno a grossly growing problem around the world.
Xenoestrogens are chemically produced compounds that have estrogenic effects and differ chemically from naturally occurring estrogenic substances such as female estrogen hormones. As a heterogeneous group of chemicals that are hormonally living compounds. Xenoestrogens show similarity to other estrogens such as phytoestrogens and mycoestrogens. Xenoestrogens also have pharmacological estrogens (estrogenic action is an intended effect, as in the contraceptive pill), but of course other chemicals can too have estrogenic effects. Xenoestrogens have been presented to the environment by industrial, agricultural, chemical companies and consumers only in the last 70 years give or take. However; archiestrogens have been a omnipresent part of the environment even prior to the existence of the human race. There is evidence that shows xenoestrogens create oncogenes by overstimulating proto-oncogenes. When an oncogene is highly stimulated it becomes a tumor cell which we all know is bad news. There is significant evidence in a variety of recent studies linking xenoestrogens to the onset of breast cancer by an increase in breast cancer growth within in the tissue of the mammary. Xenoestrogen exposure has shown to be a reason why boys have delayed pubertal onrises, these xenoestrogens have also been linked to giving pubertal boys gynecomastia or also known as GYNO. Gyno does not look appealing can really lower a young man or adult's self esteem. Gyno makes the difference of someone not being able to take of the shirt at the beach because of the fear that someone may make them feel less of a man by pointing out the gyno on his chest. (Pediatrics. 2003 Jul;112(1 Pt 2):247-52.) Xenoestrogen exposure and consumption has also been linked to testicular atrophy and reduction of gondal size. This issue leads to a hault in spermatogenesis, reproductive problems, barely or no sperm motility, an increase in estrogen to testosterone ratio which leads to the cessation of testosterone production, all these issues become VERY problematic to the HPTA.
One well known Xenoestrogen is BPA; which is known to dramatically decrease DNA methylation by increasing hypomethylation. This causes a sudden rise in estrogens which causes problems to the male endocrine system. Bisphenol A functions as a xenoestrogen by binding STRONGLY to estrogen-related receptor ***947; (ERR-***947
. This unidentified ligand behaves as a constitutive activator of transcription. BPA seems to bind strongly to ERR-***947; (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER). BPA binds to the ERR-***947; to preserve its basal constitutive activity. (J Biochem. 2007 Oct;142(4):517-24. Epub 2007 Aug 30.) BPA has also been linked to an increase in prostate size and aggrevating prostate cancer. Another study displayed how BPA is an estrogen agonist and causes PERMANENT growth in the prostate, in other words its irreversible which is NOT GOOD! Exogenous estrogen was also shown to be the culprit in permanent growth of the prostate. Just a heads up, BPA is what a lot of companies use to make their plastic, many coming from plastic bottles. You might want to give your kids more Brita or filtered water instead of plastic bottles to avoid exposure to BPA. Another option would be to avoid canned foods with their notoriety of containing BPA. The scary fact is that it does not have to be much BPA exposure in order to cause all these affects, which something people should really analyze. BPA has also been linked to causing a drop in dopamine which leads to a LOSS IN LIBIDO and a drop in memory, in other words, an aging brain. BPA has also been shown to have negative effects on the thyroids which can be detrimental to fat loss and the homeostasis of the body. I have seen people have such drastic weight fluctuations due to their thyroid malfunction condition. (Journal Of Health Science. Vol. 55 (2009), No. 2. 147-160).Nonylphenol is of the organic compounds which are subsets of the alkylphenols. Nonylphenol is a useful precursor to certain detergents/laundry detergents. They are even used in contraceptives and condoms, really scary stuff indeed. Nonylphenol is considered to be an endocrine disruptor due to frail ability to mimic estrogen and in turn; disrupt the HPTA of the male endocrine system. The effects of nonylphenol is not as potent as other Xenoestrogens because nonylphenols are not very close structural mimics of estradiol, but the levels of nonylphenol can be sufficiently high to cause damage to the male endocrine system. Nonylphenol has been commonly detected in waste water streams across the world, which is a problem since we wash our clothes with that same water. For example, nonylphenol has been detected both in the Great Lakes and in the region of New York City. Nonylphenol is persistent in the environment, therefore lingers with the potential to negatively affect the humans and of course males endocrine systems. Nonylphenol also accumulates overtime, which is dangerous to those who eat meat, another reason why people should very conscious of where they buy their meat from.
Parabens are found in lotions and also known to be xenoestrogens with pro-breast cancer activity. However it is one of the weaker forms of xenoestrogens.
There is some evidence suggesting that the food preservative BHA is also a xenoestrogen, California has already made it a policy to label BHA as a carcinogen.
DDT which is a WELL KNOWN insecticide has also a xenoestrogen has been touted as an endocrine distributor because of its negative effects on semen quality. It's a highly estrogenic component that causes a decline in testosterone. There is research that shows that DDE a metabolite of DDT acts as anti-androgen. This means that one will feel and act less like a man when exposed to it, ranging from a lack of libido to being a straight up wimp. DDT has also been linked to causing increased risks of diabetes and also provoking a lack of function within the thyroid hormones. They have also linked DDT to testicular cancer, which is more proof for how destructive this xenoestrogen is to the endocrine system. DDT is also linked to breast cancer but that is pretty obvious since it is a XENOESTROGEN.
As you can see Xenoestrogens range from sunscreen lotion to women's cosmetics, this lets you know that our endocrine system is threatened everyday just by our environment alone.
My friends the odds are stacked against us, and it does not end here.
Phytoestrogens
Phytoestrogens also known as "dietary estrogens", are a varied group of naturally occurring non-steroidal plant compounds that share of their similar structure with estradiol, and have the ability to cause estrogenic much more often than anti-estrogenic effects. Phytoestrogens primarily belong to a large group of substituted polyphenolic compounds; which comprise of the coumestans, prenylated flavonoids (the hobs you find in beer) and isoflavones (soybean are genistein and daidzein which are all bad for the endocrine system) are three of the most active in estrogenic effects in this class. The most researched and documented are the isoflavones, which are normally found in soy and red clover. Lignans have also been identified as phytoestrogens, although they are not flavonoids. Mycoestrogens have comparable structures and effects, but are not related to plants; they are mold metabolites of Fusarium. Phytoestrogens exert their effects mostly through binding to estrogen receptors (ER). There are two variants of the estrogen receptor, alpha (ER-***945
and beta (ER-***946 and numerous phytoestrogens display fairly higher affinity for ER-***946; compared to ER-***945;. Besides the interaction with estrogen receptors, phytoestrogens can also modulate the concentration of endogenous estrogen hormones by binding or ceasing efficiency of some enzymes, and this could affect the bioavailability of sex hormones by binding or stimulating the synthesis of sex hormone binding globuline. Foods with the highest relative phytoestrogen content were nuts and oilseeds, followed by soy products, cereals and breads, legumes, meat products, and other processed foods that may contain soy, vegetables, fruits, alcoholic, and nonalcoholic beverages. Flax seed and other oilseeds contained the highest total phytoestrogen content, followed by soybeans and tofu. The highest concentrations of isoflavones are found in soybeans and soybean products followed by legumes, whereas lignans are the primary source of phytoestrogens found in nuts and oilseeds (e.g. flax) and also found in cereals, legumes, fruits and vegetables.Phytoestrogen concentration varies in diverse foods, and can contrast significantly within the same group of foods depending on processing mechanisms and the type of soybean extract used. Legumes, whole grain cereals, and several seeds are high in phytoestrogens. A more broad list of foods known to have phytoestrogens includes: soybeans, tofu, soy beverages, flax, sesame seeds, barley, dried beans, lentils, apples, carrots, pomegranates, wheatberries, oats, wheat germ, rice bran, soy linseed bread, ginseng, hops bourbon, beer, fennel yams, rice, alfalfa, mung beans and anise.
There has been an increase in reports about incidences of male reproductive abnormalities and falling sperm counts have driven interest into the nature of these threats to worldwide fertility. Xenoestrogens have been flagged as major culprits. These non-steroidal estrogens/oestrogens of plant derivation are potent endocrine disruptors that modulate normal physiological functions. Phytoestrogens have also become a major factor in the usual Western fast food diet over the last few decades. Soy formula milk is another widespread source of phytoestrogens, now used increasingly as an alternative to breast or cow's milk for infants with allergies. This use is of a HUGE concern since the most vulnerable periods for oestrogenic abuse are thought to be the pre- and neonatal periods when almost irreversible harm can be brought onto the developing child. Studies concerning the safety of phytoestrogens are now needed either to relieve fears or increase awareness of the effects of our current diet on potential fertility. (2005, Vol. 8, No. 3 , Pages 197-207 (doi:10.1080/14647270500030266)).
Phytoestrogens don't even provide benefit in women
A HEALTHY women post menopausal consumes less than 1mg of phytoestrogens, which is pretty much nothing. There was a study conducted with 964 postmenopausal Caucasian women who participated in the Framingham Offspring Study and completed the Willett food-frequency questionnaire (FFQ). By searching the agricultural and medical literature, they were able to identify food sources of phytoestrogens. The concentrations of the diverse isoflavones, coumestrol and lignans in each food in the FFQ were scored in seven categories, then multiplied by the serving size of the food, and the frequency of its expenditure. The estimated daily median intake of the isoflavone daidzein was 39 microg (24-57 microg); of genistein, 70 microg (28-120 microg); of formononetin, 31 microg (13-44 microg); and of biochanin A, 6 microg (2-11 microg). Median total intake of isoflavones was 154 microg (99-235 microg). The main sources of isoflavones were peas and soy beans. The estimated daily intake of coumestans was 0.6 microg (0.2-1.7 microg), with broccoli as the key source. The estimated daily median intake of matairesinol was 19 microg (12-28 microg) and of secoisolariciresinol 560 microg (399-778 microg). The median total intake of lignans was 578 microg (416-796 microg). The main source of the lignans was fruits. (J Nutr. 2001 Jun;131(6):1826-32.)
As you see from the information above, one serving alone of these phytoestrogens can be detrimental to women's health over a period of time. Even more so to a man!
Phytoestrogens have also been linked to immunosuppressive effects along a decrease in thyroid output function. These studies that linked phytoestrogens to immunodeficiency showed how consumption of SOY isoflavone and genistein lowered t-cells which we know is something that occurs usually in HIV/AIDS patients. HIV/AIDS is a diease which causes one's immune system to shut down completely allowing one to catch any disease.
Estrogen is all around us; it is well known that the estradiol level in 55-year old men, for example, is usually a bit higher than that of a 55-year old woman. Unfortunately after the age of the 30, men's testosterone levels continue to plummet 10 percent every 10 years. Many factors lead to estrogen dominance ranging from life stress to the xenoestrogens we consume. A man, however, does not develop breasts because he has a higher testosterone level than women do and a lower estrogen ( the world is changing this).
As men age, their estradiol levels gradually rise, whereas their progesterone and testosterone levels gradually fall. The hormone balance changes. These gradual changes lead to reduction in testosterone benefits and eventually to estrogen dominance.
That is, a mans estradiol effects emerge since his testosterone level is not sufficient to block or balance out the Estrogen. The Estrogen Dominance then stimulates breast cell and prostate hypertrophy. Estrogen Dominance is responsible for the majority of breast cancers and is the only known cause of endometrial cancer in women. Since the male prostate is pretty much the equivalent of the uterus, it should not be unexpected that estrogen dominance is also a major cause of prostate cancer as stated before.
In today's world estrogen dominance is accruing at a much younger age and at a much faster rate. Even for much younger when when estrogen is not completely dominant the much higher levels of estrogen is still causing life long problems.
Estrogen dominance is a growing health concern for Men all over the world. Although it is more common in older men. It is quickly becoming a epidemic in younger men causing such problems as infertility, erectile dysfunction, enlarged prostate, and certain types of cancer. Many of the symptoms can be seen in our youth today. Many of the symptoms you may even notice in your own life.
The symptoms of estrogen dominance in men include:
Low sex drive
Impotency/erectile dysfunction
Infertility
Male pattern baldness
Gynecomastia, or "man boobs"
Weight gain
Enlarged prostate
Prostate cancer
Testicular cancer
mood swings
and many many more.
Symptoms of the on set of gyno
puffy nips
Itchy and or sore nips
lactating or fluid from the nipples
Pain to the touch
Gynecomestia
In adolescent boys, the condition is often a source of distress, but for the large majority of boys whose pubescent gynecomastia is not caused by obesity, usually the breast enlargement shrinks or disappears within several years. The condition is usually caused by an imbalance of estrogenic to androgenic (usually estradiol to testosterone ratio) effects on the breast tissue, resulting in a surge of unconstrained estrogen action on breast tissue. Approximately only 4 to 10% cases of gynecomastia are due to drugs. The aromatization takes place in the cyto-chrome enzyme P-450. Both Digoxin and Furosemide are drugs reported to cause the gyno as well, however; anabolic androgenic steroids are the most common drugs in causing gynecomastia. Breast prominence can result from hypertrophy of the breast tissue, chest adipose tissue (fat) and skin, and is normally a combination of the two. Breast distinction due exclusively to too much adipose is often termed pseudogynecomastia aka psedogyno or sometimes lipomastia.
Types of Gynecomastia
Puffy Nips: is one of the more common forms of gynecomastia. This glandular tissue buildup is concentrated under and in general confined to the areola, however; it can be slightly extended outside the areola forming a dome shaped image to the areola.
Glandular: This form of gyno is common with bodybuilders as a result of the use of anabolic androgenic steroids. The undeniable overload testosterone levels from AAS (specifically any form of test) are converted to estrogen via aromatization. Bodybuilders and along other athletes are afflicted with gynecomastia in its purest form when suffering from AAS gyno. However; drug-induced gynecomastia can almost be resolves with the use of proper supplementation, if caught before permanent fibrosis develops and even after it can still be cured.
Gynecomastia in lean men is generally only a breast tissue gland with no added adipose tissue; heavier men will have sloppier looking gyno because of the adipose tissue covering the glandular tissue. Guaranteed treatment of pure gynecomastia can be done simply by removal of the breast tissue, which also rids of the gyno tissue. Most of the time the glandular tissue is benign but at times it can become malignant, so gyno is NO laughing matter and must be taken serious especially during or after a cycle. So good bro's make sure you keep an eye out on your chest during cycle and take good care of yourself during and post cycle. Again I must stress that any and almost all gyno can be treated with out surgery but in some cases it is better to take care of it sooner rather then later.
Adolescent/Pubertal Gynecomastia: The Congenital or Hereditary Gynecomastia is on average evident by the ages of 9 to 18 in young males. About thirty percent to sixty percent of young adolescent boys experience pubertal gynecomastia. UNFORTUNATELY, thirty percent possibly will live with enlarged male breasts for the rest of their lives, but in other cases the gynecomastia will go away with age. However, severe forms of adolescent gynecomastia may require an involvement, in conference with the patient, the parents, and child development professionals. Now of course there is hope for men who have lived with gyno all of there lives. Your parents may have neglected it but there is no reason you have to.
Adult or andropause gyno: This is the most common form of gynecomastia due to declining androgen levels with a rise in estrogen in elderly or post andropause men. Gynecomastia based off of post andropause in most adults is composed mainly of glandular tissue but it may contain varying amounts of adipose and tough tissue. Now you know why old men have those wrinkly chests that look like they never had the shape of pecs on them before.
Asymmetric/Unilateral: Unilateral gynecomastia occurs when only one breast is bigger due to a case of gynecomastia. The other breast is usually normal in size and shape. Bilateral Asymmetry occurs when gynecomastia is present in both breasts, of course; each being to a different degree. Most bodybuilders and boys during puberty acquire unilateral gyno, and by a pretty big margin I might add.
Severe gynecomastia: is described as an excess or loose skin, and severely enlarged breasts. This form of gyno is determined in part by age, reason being older people suffering from gynecomastia tend to have less skin elasticity and therefore will have a greater profusion of excess skin associated to gynecomastia. Experienced plastic surgeons will perform as much of the surgical treatment of severe gynecomastia as feasible through an aereolar incision so as to avoid widespread scarring. However, some scarring may be inevitable when treating severe cases of gynecomastia. The larger the gyno the more the scaring and this is why even if you are going to have surgery once should try to reduce gyno in size as much as possible beforehand
Pseudogynecomastia: is not composed of glandular tissue, but rather of adipose tissue (fat). It looks a lot like typical gynecomastia but requires different treatment. Exercise and diet can be very effective in preventing and fighting off pseudogynecomastia. Only if this regimen is unsuccessful should surgery be considered an option. This is generally the only type of gynecomastia which can be improved with liposuction, but removal may be used in some cases as well. This form of gyno is also known as "false Gynecomastia" and is often associated with obesity whereby insulin interacts with a surplus of sugars or certain carbohydrates, specifically those of which that have been processed.
Not just estrogen causes gyno!!
PROGESTERONE. IGF, GH, AND PROLACTIN INDUCED GYNECOMASTIA
Gynecomastia can be as a result of a number of agents including estrogens, progestins, GH, IGF-1, and prolactin may all be involved. Regarding prolactin, androgens decrease prolactin levels while estrogens increase prolactin. Non-aromatizing androgens such as DHT have by no means been shown to raise prolactin levels in humans, but testosterone has, due to its aromatization to estradiol. Prolactin secreting tumors also known as prolactinomas, are often linked with gyno. Of course in these cases the prolactin is believed to induce gyno by suppressing testosterone production. Prolactinomas that are adequately large to cause gynecomastia, do cause gyno as a consequence of the impairment of Gonadotropin secretion, which leads to secondary hypogonadism. Remember Prolactin only has a direct effect on breast tissue only when estrogen is present so they say ( how much is needed?). This is why they say lowering estrogen levels will lead to lower prolactin levels and then eventually less occupied progesterone receptors. Keep in mind just using something to lower estrogen will not cure gyno when progesteonr/prolactin is one of the culprits. Also take into consideration that as IGF and GH levels rise, they will also rise within the mammary glands which could cause a growth of glandular tissue if the rise in IGF and GH is too rapid. This in basic terms means you got the GYNO.
After awhile, excess levels of prolactin also lead to laction which is when the mammary gland secretes milk. I don't know about you my friend but milk coming from my nips just is not something I want to experience. And I have no plans to feed young children even my own. Secretion is not the only way of knowing your gyno is of progesterone/prolactin nature but it is one clear indicator.
Aromatizing AAS
There are AAS that are more likely to induce gynecomastia whether it be due to aromatization or aromatization with progesterone site binding. Here is a small/general list of the more common and moderate to high aromatizing compounds.
Any form of Testosterone
Dianabol
Deca Durabolin/nanodrolone (progesterone)
MethylTestosterone
Methyltrienolone
Any form of Trenbolone (progesterone)and androgenic
Anadrol 50 Receptor cross over
Nondrolone Laurate (progesterone)
Norethandrolone
M 1,4ad
13-ethyl-3-methoxy-gona-2,5(10)-dien-17-one (progesterone)
2a, 17a-dimethyl-etiocholan-3-one-17b-ol
13 ethyl 3 methoxy
4-ad
Many people have reported receiving gyno from Superdrol, people question those accusations since superdrol is a 5aReduced compound, however; Professor Filimanov the formulator of Need2Slin.
" Prolactin is normaly caused by progestins, but can also be caused by dht, how?
For example, it is currently understood that when testosterone enters the cell cytoplasm it is subsequently converted to the more "active" androgen, dihydrotestosterone, DHT, by reduction at the 5alpha position, this is normal. Dihydrotestosterone is then either bound to a cytoplasmic "receptor" protein Rc, or is further metabolized to either 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol ,DIOL. The binding of DHT to its cytoplasmic receptor protein results in translocation of the steroid-receptor complex into the nucleus where presumably the complex dissociates and DHT exerts its androgenic effects. The transport of DHT to the nucleus can also result from the conversion of testosterone to DHT by nuclear membrane-bound 5alpha-reductase. Prolactin augmentation of DHT effects is envisioned as resulting from interaction of prolactin with its receptor, which due to the large size of the prolactin molecule is probably located in or on the plasma membrane.
Because superdrol is androgenic, but lacks the ability to show affinity via 5ar, it circulates, and this causes the large amounts of androgens to look for a transporter, so that it can bind to the androgen receptor, so it uses prolactin which has a high affinity to cytoplasmic receptor protein, allowing the androgens, testosterone, to be carried and allowing them to convert to dht, only problem is prolactin hormone or luteotropic hormone is synthesised and secreted by sex binding lactotrope cells in the adenohypophysis (anterior pituitary gland, And this gland now produces more prolactin to help deal with the large amount of testosterone circulating that hasnt bound to the estrogen of androgen receptor, Part of the reason why superdol is so anabolic, So instead of binding to the androgen receptors in the scalp and the prostrate it converts to dht through this unique process, using prolactin to enter the cytoplasmic receptror protein, and allowing it to convert to dht and then bind to the androgen receptors in the muscle, causing its distinct hardening effects, it still can't bind to the scalp or prostrate via 5ar as the form of dht it has converted too doesnt allow for that affinity.
So more prolactin is produced to allow for the superdol to find a receptor ,this excess prolactin triggers a process that fills the breast with milk via a process called lactogenesis, in men however it causes a distinct enlargment of the mammary gland and can even cause a man to lactate.
If superdrol had better binding to the androgen receptor via 5AR then this problem would be prevented, the other thing is that prolactin production can remain elevated for months after a cycle has finished, and once the androgen has been removed, ( the cycle is over) the cytoplasmic receptor proteins have nothing to do other than to allow the prolactin to proceed with its hormonal action within the body, causing the male mammary gland to enlarge ready to produce milk... Hence the REBOUND GYNO, this is why proper post cycle therapy (pct) is needed for superdrol, and the use of something to prevent prolactin."
As you see Professor Filimanov reinstates the correlation between prolactin/progesterone and estrogen which could lead to gyno even with a compound such as Superdrol.
Receptor cross over can also occur. Hormones are keys and your receptors are like locks. What happens is a hormone is ether placed in the body (by an out side source) or it is produced with in the body. This hormone we will call a "key". The hormone then sets out to find a "lock" that it can fit into,turn, and sequentially open up the components inside. To go one step more and make it a little more simple I will explain it like this.
Imagine your receptors as little treasure chest. Inside is chest it a set of instructions. This set of instructions can be a number of things. It can be directions to another chest or a task that must now be carried out. With out something to open the chest the instructions can never be carried out or the next chest found and opened. Following me ?
Some hormones are more like "dummy keys" will call them. They will find a "lock" and set them self into the "Lock hole" but then that is it. They never turn the key and open up whats inside. so we see hormones often work like this
1. Key fits a lock. AKA a hormone found a lock and set its self into it. Pretty simple
2. Key was not a dummy key and when it set its self into the lock it turned and opened up the chest letting out the instructions inside that will now be carried out.
3 "master keys" We will call them. Or "Muti function keys"
A subject not much talked about on any of the steroid forums or even in many articles I have come across is the fact that. In respect to anabolic steroids (out side source of hormones) most of them have all been explained as just "lock" and "key" . However the truth is pro hormones,disginer steroids and steroids all have "Multi function" and some even "Master key" functions.
as you can see explained earlier.
By now I am sure you are confused but that is fine. The body is a extremely complex thing and everyone's body acts the same yet differently when it comes to hormones. This is why a lot of times you must work with some one to help find out what works for you. To help find out more about you and how your body works, as well as the basics of science and how all things "should" work.
This last part has thrown many for a loop. Leaving many wondering why the have gyno when they did everything right, and used all the right compounds. The sad truth is there is no Guarantee that you will not end up with a case of gyno.
However there is one Guarantee and that being that no matter what the odds are on your side that your gyno can be reversed with proper supplementation my friends. You just need to know how. Often it is best to work with some one who has experience and has worked with many others to prevent or reverse gyno of all kinds.
Believe me friends, I know it is NOT easy by any means to feel comfortable about your body when you have gyno whether it be from puberty or AAS usage. It can really make one depressed knowing that their chest is not masculine appealing to the people around them or themselves. I know people who LOW SELF ESTEEM for years because of their pubertal gyno. We as people struggle on a daily basis to fit in whether it be through appearance, social status, or self accomplishment. The people I witnessed getting rid of their gyno, achieved all those forms of greatness and more at least to themselves which is all that matters; since it's your body and your life.
Now Of course it is time for the good part. The part every one has been waiting for. If all gyno can be cured then how?
Well My friends I am sorry to be the one to tell you. Yes there are drugs and products out there that work to reduce estrogen. Yes there are drugs that reduce progesterone and or porlactin. Yes there are serms that block the progesterone receptors. Yes all of these drugs and or supplements can be used to reduce,prevent, and even cure existing gyno.
However anyone out there giving you a cookie cutter gyno removing program is simple trying to do one thing. SELL YOU A PRODUCT/GROUP OF PRODUCTS AND OR DRUGS. Or they are only speaking from experience for what worked for them NOT YOU!!!
How many of you have used a friends advice because it worked for them,only to be disappointed when it does not work for you?
How many of us have tried everything only to find nothing worked? Or have you tried everything?
The fact of the matter is I do not hand out cookie cutter programs because although they may work for some they do not work for everyone. Each person must find out what works for them. Each person must learn how they will react to different products,drugs, and combination thereof.
One person my use nolva and it worked great for them. Another may use it and there gyno gets worse or they have a rebound long after. You must learn to read your body, learn what it is telling you. You must learn how to change things exactly when they need to be changed for you and why.
You must start off by having everything you need before hand. This is the one thing that is the same for everyone. When people make the statement "aaah just get some letro" Or hey man all you need is some arimadex and dostinex you will be fine" These people hardly know what they are talking about most of the time. They know what worked for them, they know what might have worked for others. However the most importent fact they know nothing about is WHAT WORKS FOR YOU AND HOW YOU WILL REACT.
Everyone is always looking for the cheap way out. Or the easy way out. SO often we jump all over the quick easy and cheap advice that is so readily handed out on the aas forums today.
When you are ready to do it right, when you want results, when you are at the end of your rope. Then you will bite the bullet and spend the money to get "everything" you need. A gyno removing program can have side effects and the proper supplements should be taken to counteract them.
When it comes to some causes of gyno you have to understand that it took years of exposure to out side estrogen to cause the problem. It may not be resolved overnight but it can be in the end and I am always here to help you do this.
Feel free to pm me any time my friends I am always here on the forums. :biggrin::biggrin::biggrin:
preventing Gyno of course is another topic in its self. When it comes to on cycle gyno prevention one should always use as little as he can or non at all if he can get away with it.
If you do not need it then do not use it. However always have it on hand IMO.
Many of the drugs known today for gyno prevention all have there pitfalls and some are better then others for different reasons. If prevention is what you are looking for then forma-stanzol happens to be the best choice for many different reasons. You can read more about this compound here in this thread. What is the overall best? Best steroid, best post cycle therapy (pct), best gyno treatment
5 to 10 pumps morning and night is all one would need depending on the dosing of the cycle you are on. Back up plans should always be in place and on hand. One should always have letro and dostinex on hand but never a need to use them unless nothing else works.
During post cycle therapy (pct) often people use just nolva or clomid and neglect that fact that these compounds do nothing to lower estrogen nor do they do anything at all for raised levels of prolactin or progesterone. Forma-stanzol on the other hand does.
Needtogetaas
Official Sponsor
You can read this. THen you can pm me if you like or anyone else can do the same too.
Over the last 4-5 years there has been one subject people have come to me for help with over ans over again. One subject and one problem that every man fears and no man wishes on even there worst enemy. Gyno is a horrible horrible thing to deal with. It can ruin your life, rob you of confidence and change the way you look, act, and feel about your self. Often it leaves people feeling hopeless if they can not get rid of gyno right away and then surgery seems to be the only option they have to turn to.
Gyno surgery is not a cheap option though. It can cost not only thousands of dollars but life long problems and side effects. A messed up surgery job can never be fixed and once its done you are stuck with it.
Thankfully we have advanced and many of us are starting to learn that in time almost any if not all gyno can be cured with out surgery. Some times it may only take a month or two but for others it can take up to a year. However all gyno can be cured with the right combination of drugs,products, and cycles.
The main problem is no one knows how, or is willing to trust another to show them. Well for years now I have been helping thousands of people with gyno and I am happy about what I do. I do not charge for it because I feel charging a man when he is down like that is immoral and wrong. So I offer my service free of charge to hundreds of people a day when I have the time ( I always find the time). My friends some of the info in this Article may seem jumbled or even hard to understand to many. Try and read everything and understand what you can. In the end just remember I am always here to help you and you can ask me anything you like, Send me a pm, a email, or even call me any time I am always here to help a fellow friend or brother in Iron.
Just because you think I am to busy, or because you do not know me very well yet is no reason not to contact me. I am here to serve the members of this forum and all people who need help. This is no laughing matter and some people out there need serous help. That is why I am here!!!! :biggrin: I assure you that your gyno ( any kind) can be prevented and or cured. Do not believe the hype that the only way is surgery
First before we can understand how to combat and deal with gyno we must first have a better understanding of the hormones involved with creating gyno. What they are, what they do, and even where they come from.
What is Estrogen?
Estrogen hormones are vital to the estrous cycle, and function as the primary female sex hormone. It also contains neuro-stimulative properties which is why too much estrogen can cause anxiety. Estrogen is synthesized in all vertebrate mammals as well as certain insects. The existence of these steroid hormones in both mammals and insects conveys that estrogenic sex hormones have an antique evolutionary account.
E1 (good estrogen plays a role in bone formation and bone preservation. Estrogen does also play a role in preservation of cholesterol through increasing High Density Lipoprotein levels and lowering Low Density Lipoprotein levels. Estrogen also allows for healthy looking skin since it increases the production rate of melanin which explains why women are so pretty! Just take a look at Marilyn Monroe the perfect example of a beautiful bottle shaped women with plenty of estradiol. Estrogen also keeps women in a better mood, specifically estradiol.
Unfortunately, Estrogen (E2) also plays a role in initiating prostate/breast cancer. Estrogen also aggravates blood platelet aggression which could lead to a severe blood clot, which leads to a stroke or heart attack/heart disease. Estrogen decreases fecal matter motility which leads to constipation. Estrogen also leads to loss of muscle mass and gains of fat deposits within the adipose tissues. Estrogen also leads to an increase in cortisol levels along with a rise in SHBG's. This quickly will lead to a DROP IN TESTOSTERONE! In theory, this could explain why steroid user's testosterone levels do not come back 100% percent with when usinga SERM alone for post cycle therapy (pct)!! there is documentation showing that Selective Estrogen Modulators raise SHBG levels as well as studies that show they " raise not lower" estrogen levels.
There are other sources of estrogen as well; the other common types are xenoestrogens, mycoestrogens, and phytoestrogens.
These are outside sources of estrogen and we encounter them every day of our lives. often they are the cause for pubertal gyno a grossly growing problem around the world.
Xenoestrogens are chemically produced compounds that have estrogenic effects and differ chemically from naturally occurring estrogenic substances such as female estrogen hormones. As a heterogeneous group of chemicals that are hormonally living compounds. Xenoestrogens show similarity to other estrogens such as phytoestrogens and mycoestrogens. Xenoestrogens also have pharmacological estrogens (estrogenic action is an intended effect, as in the contraceptive pill), but of course other chemicals can too have estrogenic effects. Xenoestrogens have been presented to the environment by industrial, agricultural, chemical companies and consumers only in the last 70 years give or take. However; archiestrogens have been a omnipresent part of the environment even prior to the existence of the human race. There is evidence that shows xenoestrogens create oncogenes by overstimulating proto-oncogenes. When an oncogene is highly stimulated it becomes a tumor cell which we all know is bad news. There is significant evidence in a variety of recent studies linking xenoestrogens to the onset of breast cancer by an increase in breast cancer growth within in the tissue of the mammary. Xenoestrogen exposure has shown to be a reason why boys have delayed pubertal onrises, these xenoestrogens have also been linked to giving pubertal boys gynecomastia or also known as GYNO. Gyno does not look appealing can really lower a young man or adult's self esteem. Gyno makes the difference of someone not being able to take of the shirt at the beach because of the fear that someone may make them feel less of a man by pointing out the gyno on his chest. (Pediatrics. 2003 Jul;112(1 Pt 2):247-52.) Xenoestrogen exposure and consumption has also been linked to testicular atrophy and reduction of gondal size. This issue leads to a hault in spermatogenesis, reproductive problems, barely or no sperm motility, an increase in estrogen to testosterone ratio which leads to the cessation of testosterone production, all these issues become VERY problematic to the HPTA.
One well known Xenoestrogen is BPA; which is known to dramatically decrease DNA methylation by increasing hypomethylation. This causes a sudden rise in estrogens which causes problems to the male endocrine system. Bisphenol A functions as a xenoestrogen by binding STRONGLY to estrogen-related receptor ***947; (ERR-***947. This unidentified ligand behaves as a constitutive activator of transcription. BPA seems to bind strongly to ERR-***947; (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER). BPA binds to the ERR-***947; to preserve its basal constitutive activity. (J Biochem. 2007 Oct;142(4):517-24. Epub 2007 Aug 30.) BPA has also been linked to an increase in prostate size and aggrevating prostate cancer. Another study displayed how BPA is an estrogen agonist and causes PERMANENT growth in the prostate, in other words its irreversible which is NOT GOOD! Exogenous estrogen was also shown to be the culprit in permanent growth of the prostate. Just a heads up, BPA is what a lot of companies use to make their plastic, many coming from plastic bottles. You might want to give your kids more Brita or filtered water instead of plastic bottles to avoid exposure to BPA. Another option would be to avoid canned foods with their notoriety of containing BPA. The scary fact is that it does not have to be much BPA exposure in order to cause all these affects, which something people should really analyze. BPA has also been linked to causing a drop in dopamine which leads to a LOSS IN LIBIDO and a drop in memory, in other words, an aging brain. BPA has also been shown to have negative effects on the thyroids which can be detrimental to fat loss and the homeostasis of the body. I have seen people have such drastic weight fluctuations due to their thyroid malfunction condition. (Journal Of Health Science. Vol. 55 (2009), No. 2. 147-160).
Nonylphenol is of the organic compounds which are subsets of the alkylphenols. Nonylphenol is a useful precursor to certain detergents/laundry detergents. They are even used in contraceptives and condoms, really scary stuff indeed. Nonylphenol is considered to be an endocrine disruptor due to frail ability to mimic estrogen and in turn; disrupt the HPTA of the male endocrine system. The effects of nonylphenol is not as potent as other Xenoestrogens because nonylphenols are not very close structural mimics of estradiol, but the levels of nonylphenol can be sufficiently high to cause damage to the male endocrine system. Nonylphenol has been commonly detected in waste water streams across the world, which is a problem since we wash our clothes with that same water. For example, nonylphenol has been detected both in the Great Lakes and in the region of New York City. Nonylphenol is persistent in the environment, therefore lingers with the potential to negatively affect the humans and of course males endocrine systems. Nonylphenol also accumulates overtime, which is dangerous to those who eat meat, another reason why people should very conscious of where they buy their meat from.
Parabens are found in lotions and also known to be xenoestrogens with pro-breast cancer activity. However it is one of the weaker forms of xenoestrogens.
There is some evidence suggesting that the food preservative BHA is also a xenoestrogen, California has already made it a policy to label BHA as a carcinogen.
DDT which is a WELL KNOWN insecticide has also a xenoestrogen has been touted as an endocrine distributor because of its negative effects on semen quality. It's a highly estrogenic component that causes a decline in testosterone. There is research that shows that DDE a metabolite of DDT acts as anti-androgen. This means that one will feel and act less like a man when exposed to it, ranging from a lack of libido to being a straight up wimp. DDT has also been linked to causing increased risks of diabetes and also provoking a lack of function within the thyroid hormones. They have also linked DDT to testicular cancer, which is more proof for how destructive this xenoestrogen is to the endocrine system. DDT is also linked to breast cancer but that is pretty obvious since it is a XENOESTROGEN.
As you can see Xenoestrogens range from sunscreen lotion to women's cosmetics, this lets you know that our endocrine system is threatened everyday just by our environment alone.
My friends the odds are stacked against us, and it does not end here.
Phytoestrogens
Phytoestrogens also known as "dietary estrogens", are a varied group of naturally occurring non-steroidal plant compounds that share of their similar structure with estradiol, and have the ability to cause estrogenic much more often than anti-estrogenic effects. Phytoestrogens primarily belong to a large group of substituted polyphenolic compounds; which comprise of the coumestans, prenylated flavonoids (the hobs you find in beer) and isoflavones (soybean are genistein and daidzein which are all bad for the endocrine system) are three of the most active in estrogenic effects in this class. The most researched and documented are the isoflavones, which are normally found in soy and red clover. Lignans have also been identified as phytoestrogens, although they are not flavonoids. Mycoestrogens have comparable structures and effects, but are not related to plants; they are mold metabolites of Fusarium. Phytoestrogens exert their effects mostly through binding to estrogen receptors (ER). There are two variants of the estrogen receptor, alpha (ER-***945 and beta (ER-***946 and numerous phytoestrogens display fairly higher affinity for ER-***946; compared to ER-***945;. Besides the interaction with estrogen receptors, phytoestrogens can also modulate the concentration of endogenous estrogen hormones by binding or ceasing efficiency of some enzymes, and this could affect the bioavailability of sex hormones by binding or stimulating the synthesis of sex hormone binding globuline. Foods with the highest relative phytoestrogen content were nuts and oilseeds, followed by soy products, cereals and breads, legumes, meat products, and other processed foods that may contain soy, vegetables, fruits, alcoholic, and nonalcoholic beverages. Flax seed and other oilseeds contained the highest total phytoestrogen content, followed by soybeans and tofu. The highest concentrations of isoflavones are found in soybeans and soybean products followed by legumes, whereas lignans are the primary source of phytoestrogens found in nuts and oilseeds (e.g. flax) and also found in cereals, legumes, fruits and vegetables.
Phytoestrogen concentration varies in diverse foods, and can contrast significantly within the same group of foods depending on processing mechanisms and the type of soybean extract used. Legumes, whole grain cereals, and several seeds are high in phytoestrogens. A more broad list of foods known to have phytoestrogens includes: soybeans, tofu, soy beverages, flax, sesame seeds, barley, dried beans, lentils, apples, carrots, pomegranates, wheatberries, oats, wheat germ, rice bran, soy linseed bread, ginseng, hops bourbon, beer, fennel yams, rice, alfalfa, mung beans and anise.
There has been an increase in reports about incidences of male reproductive abnormalities and falling sperm counts have driven interest into the nature of these threats to worldwide fertility. Xenoestrogens have been flagged as major culprits. These non-steroidal estrogens/oestrogens of plant derivation are potent endocrine disruptors that modulate normal physiological functions. Phytoestrogens have also become a major factor in the usual Western fast food diet over the last few decades. Soy formula milk is another widespread source of phytoestrogens, now used increasingly as an alternative to breast or cow's milk for infants with allergies. This use is of a HUGE concern since the most vulnerable periods for oestrogenic abuse are thought to be the pre- and neonatal periods when almost irreversible harm can be brought onto the developing child. Studies concerning the safety of phytoestrogens are now needed either to relieve fears or increase awareness of the effects of our current diet on potential fertility. (2005, Vol. 8, No. 3 , Pages 197-207 (doi:10.1080/14647270500030266)).
Phytoestrogens don't even provide benefit in women
A HEALTHY women post menopausal consumes less than 1mg of phytoestrogens, which is pretty much nothing. There was a study conducted with 964 postmenopausal Caucasian women who participated in the Framingham Offspring Study and completed the Willett food-frequency questionnaire (FFQ). By searching the agricultural and medical literature, they were able to identify food sources of phytoestrogens. The concentrations of the diverse isoflavones, coumestrol and lignans in each food in the FFQ were scored in seven categories, then multiplied by the serving size of the food, and the frequency of its expenditure. The estimated daily median intake of the isoflavone daidzein was 39 microg (24-57 microg); of genistein, 70 microg (28-120 microg); of formononetin, 31 microg (13-44 microg); and of biochanin A, 6 microg (2-11 microg). Median total intake of isoflavones was 154 microg (99-235 microg). The main sources of isoflavones were peas and soy beans. The estimated daily intake of coumestans was 0.6 microg (0.2-1.7 microg), with broccoli as the key source. The estimated daily median intake of matairesinol was 19 microg (12-28 microg) and of secoisolariciresinol 560 microg (399-778 microg). The median total intake of lignans was 578 microg (416-796 microg). The main source of the lignans was fruits. (J Nutr. 2001 Jun;131(6):1826-32.)
As you see from the information above, one serving alone of these phytoestrogens can be detrimental to women's health over a period of time. Even more so to a man!
Phytoestrogens have also been linked to immunosuppressive effects along a decrease in thyroid output function. These studies that linked phytoestrogens to immunodeficiency showed how consumption of SOY isoflavone and genistein lowered t-cells which we know is something that occurs usually in HIV/AIDS patients. HIV/AIDS is a diease which causes one's immune system to shut down completely allowing one to catch any disease.
Estrogen is all around us; it is well known that the estradiol level in 55-year old men, for example, is usually a bit higher than that of a 55-year old woman. Unfortunately after the age of the 30, men's testosterone levels continue to plummet 10 percent every 10 years. Many factors lead to estrogen dominance ranging from life stress to the xenoestrogens we consume. A man, however, does not develop breasts because he has a higher testosterone level than women do and a lower estrogen ( the world is changing this).
As men age, their estradiol levels gradually rise, whereas their progesterone and testosterone levels gradually fall. The hormone balance changes. These gradual changes lead to reduction in testosterone benefits and eventually to estrogen dominance.
That is, a mans estradiol effects emerge since his testosterone level is not sufficient to block or balance out the Estrogen. The Estrogen Dominance then stimulates breast cell and prostate hypertrophy. Estrogen Dominance is responsible for the majority of breast cancers and is the only known cause of endometrial cancer in women. Since the male prostate is pretty much the equivalent of the uterus, it should not be unexpected that estrogen dominance is also a major cause of prostate cancer as stated before.
In today's world estrogen dominance is accruing at a much younger age and at a much faster rate. Even for much younger when when estrogen is not completely dominant the much higher levels of estrogen is still causing life long problems.
Estrogen dominance is a growing health concern for Men all over the world. Although it is more common in older men. It is quickly becoming a epidemic in younger men causing such problems as infertility, erectile dysfunction, enlarged prostate, and certain types of cancer. Many of the symptoms can be seen in our youth today. Many of the symptoms you may even notice in your own life.
The symptoms of estrogen dominance in men include:
Low sex drive
Impotency/erectile dysfunction
Infertility
Male pattern baldness
Gynecomastia, or "man boobs"
Weight gain
Enlarged prostate
Prostate cancer
Testicular cancer
mood swings
and many many more.
Symptoms of the on set of gyno
puffy nips
Itchy and or sore nips
lactating or fluid from the nipples
Pain to the touch
Gynecomestia
In adolescent boys, the condition is often a source of distress, but for the large majority of boys whose pubescent gynecomastia is not caused by obesity, usually the breast enlargement shrinks or disappears within several years. The condition is usually caused by an imbalance of estrogenic to androgenic (usually estradiol to testosterone ratio) effects on the breast tissue, resulting in a surge of unconstrained estrogen action on breast tissue. Approximately only 4 to 10% cases of gynecomastia are due to drugs. The aromatization takes place in the cyto-chrome enzyme P-450. Both Digoxin and Furosemide are drugs reported to cause the gyno as well, however; anabolic androgenic steroids are the most common drugs in causing gynecomastia. Breast prominence can result from hypertrophy of the breast tissue, chest adipose tissue (fat) and skin, and is normally a combination of the two. Breast distinction due exclusively to too much adipose is often termed pseudogynecomastia aka psedogyno or sometimes lipomastia.
Types of Gynecomastia
Puffy Nips: is one of the more common forms of gynecomastia. This glandular tissue buildup is concentrated under and in general confined to the areola, however; it can be slightly extended outside the areola forming a dome shaped image to the areola.
Glandular: This form of gyno is common with bodybuilders as a result of the use of anabolic androgenic steroids. The undeniable overload testosterone levels from AAS (specifically any form of test) are converted to estrogen via aromatization. Bodybuilders and along other athletes are afflicted with gynecomastia in its purest form when suffering from AAS gyno. However; drug-induced gynecomastia can almost be resolves with the use of proper supplementation, if caught before permanent fibrosis develops and even after it can still be cured.
Gynecomastia in lean men is generally only a breast tissue gland with no added adipose tissue; heavier men will have sloppier looking gyno because of the adipose tissue covering the glandular tissue. Guaranteed treatment of pure gynecomastia can be done simply by removal of the breast tissue, which also rids of the gyno tissue. Most of the time the glandular tissue is benign but at times it can become malignant, so gyno is NO laughing matter and must be taken serious especially during or after a cycle. So good bro's make sure you keep an eye out on your chest during cycle and take good care of yourself during and post cycle. Again I must stress that any and almost all gyno can be treated with out surgery but in some cases it is better to take care of it sooner rather then later.
Adolescent/Pubertal Gynecomastia: The Congenital or Hereditary Gynecomastia is on average evident by the ages of 9 to 18 in young males. About thirty percent to sixty percent of young adolescent boys experience pubertal gynecomastia. UNFORTUNATELY, thirty percent possibly will live with enlarged male breasts for the rest of their lives, but in other cases the gynecomastia will go away with age. However, severe forms of adolescent gynecomastia may require an involvement, in conference with the patient, the parents, and child development professionals. Now of course there is hope for men who have lived with gyno all of there lives. Your parents may have neglected it but there is no reason you have to.
Adult or andropause gyno: This is the most common form of gynecomastia due to declining androgen levels with a rise in estrogen in elderly or post andropause men. Gynecomastia based off of post andropause in most adults is composed mainly of glandular tissue but it may contain varying amounts of adipose and tough tissue. Now you know why old men have those wrinkly chests that look like they never had the shape of pecs on them before.
Asymmetric/Unilateral: Unilateral gynecomastia occurs when only one breast is bigger due to a case of gynecomastia. The other breast is usually normal in size and shape. Bilateral Asymmetry occurs when gynecomastia is present in both breasts, of course; each being to a different degree. Most bodybuilders and boys during puberty acquire unilateral gyno, and by a pretty big margin I might add.
Severe gynecomastia: is described as an excess or loose skin, and severely enlarged breasts. This form of gyno is determined in part by age, reason being older people suffering from gynecomastia tend to have less skin elasticity and therefore will have a greater profusion of excess skin associated to gynecomastia. Experienced plastic surgeons will perform as much of the surgical treatment of severe gynecomastia as feasible through an aereolar incision so as to avoid widespread scarring. However, some scarring may be inevitable when treating severe cases of gynecomastia. The larger the gyno the more the scaring and this is why even if you are going to have surgery once should try to reduce gyno in size as much as possible beforehand
Pseudogynecomastia: is not composed of glandular tissue, but rather of adipose tissue (fat). It looks a lot like typical gynecomastia but requires different treatment. Exercise and diet can be very effective in preventing and fighting off pseudogynecomastia. Only if this regimen is unsuccessful should surgery be considered an option. This is generally the only type of gynecomastia which can be improved with liposuction, but removal may be used in some cases as well. This form of gyno is also known as "false Gynecomastia" and is often associated with obesity whereby insulin interacts with a surplus of sugars or certain carbohydrates, specifically those of which that have been processed.
Not just estrogen causes gyno!!
PROGESTERONE. IGF, GH, AND PROLACTIN INDUCED GYNECOMASTIA
Gynecomastia can be as a result of a number of agents including estrogens, progestins, GH, IGF-1, and prolactin may all be involved. Regarding prolactin, androgens decrease prolactin levels while estrogens increase prolactin. Non-aromatizing androgens such as DHT have by no means been shown to raise prolactin levels in humans, but testosterone has, due to its aromatization to estradiol. Prolactin secreting tumors also known as prolactinomas, are often linked with gyno. Of course in these cases the prolactin is believed to induce gyno by suppressing testosterone production. Prolactinomas that are adequately large to cause gynecomastia, do cause gyno as a consequence of the impairment of Gonadotropin secretion, which leads to secondary hypogonadism. Remember Prolactin only has a direct effect on breast tissue only when estrogen is present so they say ( how much is needed?). This is why they say lowering estrogen levels will lead to lower prolactin levels and then eventually less occupied progesterone receptors. Keep in mind just using something to lower estrogen will not cure gyno when progesteonr/prolactin is one of the culprits. Also take into consideration that as IGF and GH levels rise, they will also rise within the mammary glands which could cause a growth of glandular tissue if the rise in IGF and GH is too rapid. This in basic terms means you got the GYNO.
After awhile, excess levels of prolactin also lead to laction which is when the mammary gland secretes milk. I don't know about you my friend but milk coming from my nips just is not something I want to experience. And I have no plans to feed young children even my own. Secretion is not the only way of knowing your gyno is of progesterone/prolactin nature but it is one clear indicator.
Aromatizing AAS
There are AAS that are more likely to induce gynecomastia whether it be due to aromatization or aromatization with progesterone site binding. Here is a small/general list of the more common and moderate to high aromatizing compounds.
Any form of Testosterone
Dianabol
Deca Durabolin/nanodrolone (progesterone)
MethylTestosterone
Methyltrienolone
Any form of Trenbolone (progesterone)and androgenic
Anadrol 50 Receptor cross over
Nondrolone Laurate (progesterone)
Norethandrolone
M 1,4ad
13-ethyl-3-methoxy-gona-2,5(10)-dien-17-one (progesterone)
2a, 17a-dimethyl-etiocholan-3-one-17b-ol
13 ethyl 3 methoxy
4-ad
Many people have reported receiving gyno from Superdrol, people question those accusations since superdrol is a 5aReduced compound, however; Professor Filimanov the formulator of Need2Slin.
" Prolactin is normaly caused by progestins, but can also be caused by dht, how?
For example, it is currently understood that when testosterone enters the cell cytoplasm it is subsequently converted to the more "active" androgen, dihydrotestosterone, DHT, by reduction at the 5alpha position, this is normal. Dihydrotestosterone is then either bound to a cytoplasmic "receptor" protein Rc, or is further metabolized to either 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol ,DIOL. The binding of DHT to its cytoplasmic receptor protein results in translocation of the steroid-receptor complex into the nucleus where presumably the complex dissociates and DHT exerts its androgenic effects. The transport of DHT to the nucleus can also result from the conversion of testosterone to DHT by nuclear membrane-bound 5alpha-reductase. Prolactin augmentation of DHT effects is envisioned as resulting from interaction of prolactin with its receptor, which due to the large size of the prolactin molecule is probably located in or on the plasma membrane.
Because superdrol is androgenic, but lacks the ability to show affinity via 5ar, it circulates, and this causes the large amounts of androgens to look for a transporter, so that it can bind to the androgen receptor, so it uses prolactin which has a high affinity to cytoplasmic receptor protein, allowing the androgens, testosterone, to be carried and allowing them to convert to dht, only problem is prolactin hormone or luteotropic hormone is synthesised and secreted by sex binding lactotrope cells in the adenohypophysis (anterior pituitary gland, And this gland now produces more prolactin to help deal with the large amount of testosterone circulating that hasnt bound to the estrogen of androgen receptor, Part of the reason why superdol is so anabolic, So instead of binding to the androgen receptors in the scalp and the prostrate it converts to dht through this unique process, using prolactin to enter the cytoplasmic receptror protein, and allowing it to convert to dht and then bind to the androgen receptors in the muscle, causing its distinct hardening effects, it still can't bind to the scalp or prostrate via 5ar as the form of dht it has converted too doesnt allow for that affinity.
So more prolactin is produced to allow for the superdol to find a receptor ,this excess prolactin triggers a process that fills the breast with milk via a process called lactogenesis, in men however it causes a distinct enlargment of the mammary gland and can even cause a man to lactate.
If superdrol had better binding to the androgen receptor via 5AR then this problem would be prevented, the other thing is that prolactin production can remain elevated for months after a cycle has finished, and once the androgen has been removed, ( the cycle is over) the cytoplasmic receptor proteins have nothing to do other than to allow the prolactin to proceed with its hormonal action within the body, causing the male mammary gland to enlarge ready to produce milk... Hence the REBOUND GYNO, this is why proper post cycle therapy (pct) is needed for superdrol, and the use of something to prevent prolactin."
As you see Professor Filimanov reinstates the correlation between prolactin/progesterone and estrogen which could lead to gyno even with a compound such as Superdrol.
Receptor cross over can also occur. Hormones are keys and your receptors are like locks. What happens is a hormone is ether placed in the body (by an out side source) or it is produced with in the body. This hormone we will call a "key". The hormone then sets out to find a "lock" that it can fit into,turn, and sequentially open up the components inside. To go one step more and make it a little more simple I will explain it like this.
Imagine your receptors as little treasure chest. Inside is chest it a set of instructions. This set of instructions can be a number of things. It can be directions to another chest or a task that must now be carried out. With out something to open the chest the instructions can never be carried out or the next chest found and opened. Following me ?
Some hormones are more like "dummy keys" will call them. They will find a "lock" and set them self into the "Lock hole" but then that is it. They never turn the key and open up whats inside. so we see hormones often work like this
1. Key fits a lock. AKA a hormone found a lock and set its self into it. Pretty simple
2. Key was not a dummy key and when it set its self into the lock it turned and opened up the chest letting out the instructions inside that will now be carried out.
3 "master keys" We will call them. Or "Muti function keys"
A subject not much talked about on any of the steroid forums or even in many articles I have come across is the fact that. In respect to anabolic steroids (out side source of hormones) most of them have all been explained as just "lock" and "key" . However the truth is pro hormones,disginer steroids and steroids all have "Multi function" and some even "Master key" functions.
as you can see explained earlier.
By now I am sure you are confused but that is fine. The body is a extremely complex thing and everyone's body acts the same yet differently when it comes to hormones. This is why a lot of times you must work with some one to help find out what works for you. To help find out more about you and how your body works, as well as the basics of science and how all things "should" work.
This last part has thrown many for a loop. Leaving many wondering why the have gyno when they did everything right, and used all the right compounds. The sad truth is there is no Guarantee that you will not end up with a case of gyno.
However there is one Guarantee and that being that no matter what the odds are on your side that your gyno can be reversed with proper supplementation my friends. You just need to know how. Often it is best to work with some one who has experience and has worked with many others to prevent or reverse gyno of all kinds.
Believe me friends, I know it is NOT easy by any means to feel comfortable about your body when you have gyno whether it be from puberty or AAS usage. It can really make one depressed knowing that their chest is not masculine appealing to the people around them or themselves. I know people who LOW SELF ESTEEM for years because of their pubertal gyno. We as people struggle on a daily basis to fit in whether it be through appearance, social status, or self accomplishment. The people I witnessed getting rid of their gyno, achieved all those forms of greatness and more at least to themselves which is all that matters; since it's your body and your life.
Now Of course it is time for the good part. The part every one has been waiting for. If all gyno can be cured then how?
Well My friends I am sorry to be the one to tell you. Yes there are drugs and products out there that work to reduce estrogen. Yes there are drugs that reduce progesterone and or porlactin. Yes there are serms that block the progesterone receptors. Yes all of these drugs and or supplements can be used to reduce,prevent, and even cure existing gyno.
However anyone out there giving you a cookie cutter gyno removing program is simple trying to do one thing. SELL YOU A PRODUCT/GROUP OF PRODUCTS AND OR DRUGS. Or they are only speaking from experience for what worked for them NOT YOU!!!
How many of you have used a friends advice because it worked for them,only to be disappointed when it does not work for you?
How many of us have tried everything only to find nothing worked? Or have you tried everything?
The fact of the matter is I do not hand out cookie cutter programs because although they may work for some they do not work for everyone. Each person must find out what works for them. Each person must learn how they will react to different products,drugs, and combination thereof.
One person my use nolva and it worked great for them. Another may use it and there gyno gets worse or they have a rebound long after. You must learn to read your body, learn what it is telling you. You must learn how to change things exactly when they need to be changed for you and why.
You must start off by having everything you need before hand. This is the one thing that is the same for everyone. When people make the statement "aaah just get some letro" Or hey man all you need is some arimadex and dostinex you will be fine" These people hardly know what they are talking about most of the time. They know what worked for them, they know what might have worked for others. However the most importent fact they know nothing about is WHAT WORKS FOR YOU AND HOW YOU WILL REACT.
Everyone is always looking for the cheap way out. Or the easy way out. SO often we jump all over the quick easy and cheap advice that is so readily handed out on the aas forums today.
When you are ready to do it right, when you want results, when you are at the end of your rope. Then you will bite the bullet and spend the money to get "everything" you need. A gyno removing program can have side effects and the proper supplements should be taken to counteract them.
When it comes to some causes of gyno you have to understand that it took years of exposure to out side estrogen to cause the problem. It may not be resolved overnight but it can be in the end and I am always here to help you do this.
Feel free to pm me any time my friends I am always here on the forums. :biggrin::biggrin::biggrin:
preventing Gyno of course is another topic in its self. When it comes to on cycle gyno prevention one should always use as little as he can or non at all if he can get away with it.
If you do not need it then do not use it. However always have it on hand IMO.
Many of the drugs known today for gyno prevention all have there pitfalls and some are better then others for different reasons. If prevention is what you are looking for then forma-stanzol happens to be the best choice for many different reasons. You can read more about this compound here in this thread. What is the overall best? Best steroid, best post cycle therapy (pct), best gyno treatment
5 to 10 pumps morning and night is all one would need depending on the dosing of the cycle you are on. Back up plans should always be in place and on hand. One should always have letro and dostinex on hand but never a need to use them unless nothing else works.
During post cycle therapy (pct) often people use just nolva or clomid and neglect that fact that these compounds do nothing to lower estrogen nor do they do anything at all for raised levels of prolactin or progesterone. Forma-stanzol on the other hand does.
Over the last 4-5 years there has been one subject people have come to me for help with over ans over again. One subject and one problem that every man fears and no man wishes on even there worst enemy. Gyno is a horrible horrible thing to deal with. It can ruin your life, rob you of confidence and change the way you look, act, and feel about your self. Often it leaves people feeling hopeless if they can not get rid of gyno right away and then surgery seems to be the only option they have to turn to.
Gyno surgery is not a cheap option though. It can cost not only thousands of dollars but life long problems and side effects. A messed up surgery job can never be fixed and once its done you are stuck with it.
Thankfully we have advanced and many of us are starting to learn that in time almost any if not all gyno can be cured with out surgery. Some times it may only take a month or two but for others it can take up to a year. However all gyno can be cured with the right combination of drugs,products, and cycles.
The main problem is no one knows how, or is willing to trust another to show them. Well for years now I have been helping thousands of people with gyno and I am happy about what I do. I do not charge for it because I feel charging a man when he is down like that is immoral and wrong. So I offer my service free of charge to hundreds of people a day when I have the time ( I always find the time). My friends some of the info in this Article may seem jumbled or even hard to understand to many. Try and read everything and understand what you can. In the end just remember I am always here to help you and you can ask me anything you like, Send me a pm, a email, or even call me any time I am always here to help a fellow friend or brother in Iron.
Just because you think I am to busy, or because you do not know me very well yet is no reason not to contact me. I am here to serve the members of this forum and all people who need help. This is no laughing matter and some people out there need serous help. That is why I am here!!!! :biggrin: I assure you that your gyno ( any kind) can be prevented and or cured. Do not believe the hype that the only way is surgery
First before we can understand how to combat and deal with gyno we must first have a better understanding of the hormones involved with creating gyno. What they are, what they do, and even where they come from.
What is Estrogen?
Estrogen hormones are vital to the estrous cycle, and function as the primary female sex hormone. It also contains neuro-stimulative properties which is why too much estrogen can cause anxiety. Estrogen is synthesized in all vertebrate mammals as well as certain insects. The existence of these steroid hormones in both mammals and insects conveys that estrogenic sex hormones have an antique evolutionary account.
E1 (good estrogen plays a role in bone formation and bone preservation. Estrogen does also play a role in preservation of cholesterol through increasing High Density Lipoprotein levels and lowering Low Density Lipoprotein levels. Estrogen also allows for healthy looking skin since it increases the production rate of melanin which explains why women are so pretty! Just take a look at Marilyn Monroe the perfect example of a beautiful bottle shaped women with plenty of estradiol. Estrogen also keeps women in a better mood, specifically estradiol.
Unfortunately, Estrogen (E2) also plays a role in initiating prostate/breast cancer. Estrogen also aggravates blood platelet aggression which could lead to a severe blood clot, which leads to a stroke or heart attack/heart disease. Estrogen decreases fecal matter motility which leads to constipation. Estrogen also leads to loss of muscle mass and gains of fat deposits within the adipose tissues. Estrogen also leads to an increase in cortisol levels along with a rise in SHBG's. This quickly will lead to a DROP IN TESTOSTERONE! In theory, this could explain why steroid user's testosterone levels do not come back 100% percent with when usinga SERM alone for post cycle therapy (pct)!! there is documentation showing that Selective Estrogen Modulators raise SHBG levels as well as studies that show they " raise not lower" estrogen levels.
There are other sources of estrogen as well; the other common types are xenoestrogens, mycoestrogens, and phytoestrogens.
These are outside sources of estrogen and we encounter them every day of our lives. often they are the cause for pubertal gyno a grossly growing problem around the world.
Xenoestrogens are chemically produced compounds that have estrogenic effects and differ chemically from naturally occurring estrogenic substances such as female estrogen hormones. As a heterogeneous group of chemicals that are hormonally living compounds. Xenoestrogens show similarity to other estrogens such as phytoestrogens and mycoestrogens. Xenoestrogens also have pharmacological estrogens (estrogenic action is an intended effect, as in the contraceptive pill), but of course other chemicals can too have estrogenic effects. Xenoestrogens have been presented to the environment by industrial, agricultural, chemical companies and consumers only in the last 70 years give or take. However; archiestrogens have been a omnipresent part of the environment even prior to the existence of the human race. There is evidence that shows xenoestrogens create oncogenes by overstimulating proto-oncogenes. When an oncogene is highly stimulated it becomes a tumor cell which we all know is bad news. There is significant evidence in a variety of recent studies linking xenoestrogens to the onset of breast cancer by an increase in breast cancer growth within in the tissue of the mammary. Xenoestrogen exposure has shown to be a reason why boys have delayed pubertal onrises, these xenoestrogens have also been linked to giving pubertal boys gynecomastia or also known as GYNO. Gyno does not look appealing can really lower a young man or adult's self esteem. Gyno makes the difference of someone not being able to take of the shirt at the beach because of the fear that someone may make them feel less of a man by pointing out the gyno on his chest. (Pediatrics. 2003 Jul;112(1 Pt 2):247-52.) Xenoestrogen exposure and consumption has also been linked to testicular atrophy and reduction of gondal size. This issue leads to a hault in spermatogenesis, reproductive problems, barely or no sperm motility, an increase in estrogen to testosterone ratio which leads to the cessation of testosterone production, all these issues become VERY problematic to the HPTA.
One well known Xenoestrogen is BPA; which is known to dramatically decrease DNA methylation by increasing hypomethylation. This causes a sudden rise in estrogens which causes problems to the male endocrine system. Bisphenol A functions as a xenoestrogen by binding STRONGLY to estrogen-related receptor ***947; (ERR-***947
. This unidentified ligand behaves as a constitutive activator of transcription. BPA seems to bind strongly to ERR-***947; (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER). BPA binds to the ERR-***947; to preserve its basal constitutive activity. (J Biochem. 2007 Oct;142(4):517-24. Epub 2007 Aug 30.) BPA has also been linked to an increase in prostate size and aggrevating prostate cancer. Another study displayed how BPA is an estrogen agonist and causes PERMANENT growth in the prostate, in other words its irreversible which is NOT GOOD! Exogenous estrogen was also shown to be the culprit in permanent growth of the prostate. Just a heads up, BPA is what a lot of companies use to make their plastic, many coming from plastic bottles. You might want to give your kids more Brita or filtered water instead of plastic bottles to avoid exposure to BPA. Another option would be to avoid canned foods with their notoriety of containing BPA. The scary fact is that it does not have to be much BPA exposure in order to cause all these affects, which something people should really analyze. BPA has also been linked to causing a drop in dopamine which leads to a LOSS IN LIBIDO and a drop in memory, in other words, an aging brain. BPA has also been shown to have negative effects on the thyroids which can be detrimental to fat loss and the homeostasis of the body. I have seen people have such drastic weight fluctuations due to their thyroid malfunction condition. (Journal Of Health Science. Vol. 55 (2009), No. 2. 147-160).Nonylphenol is of the organic compounds which are subsets of the alkylphenols. Nonylphenol is a useful precursor to certain detergents/laundry detergents. They are even used in contraceptives and condoms, really scary stuff indeed. Nonylphenol is considered to be an endocrine disruptor due to frail ability to mimic estrogen and in turn; disrupt the HPTA of the male endocrine system. The effects of nonylphenol is not as potent as other Xenoestrogens because nonylphenols are not very close structural mimics of estradiol, but the levels of nonylphenol can be sufficiently high to cause damage to the male endocrine system. Nonylphenol has been commonly detected in waste water streams across the world, which is a problem since we wash our clothes with that same water. For example, nonylphenol has been detected both in the Great Lakes and in the region of New York City. Nonylphenol is persistent in the environment, therefore lingers with the potential to negatively affect the humans and of course males endocrine systems. Nonylphenol also accumulates overtime, which is dangerous to those who eat meat, another reason why people should very conscious of where they buy their meat from.
Parabens are found in lotions and also known to be xenoestrogens with pro-breast cancer activity. However it is one of the weaker forms of xenoestrogens.
There is some evidence suggesting that the food preservative BHA is also a xenoestrogen, California has already made it a policy to label BHA as a carcinogen.
DDT which is a WELL KNOWN insecticide has also a xenoestrogen has been touted as an endocrine distributor because of its negative effects on semen quality. It's a highly estrogenic component that causes a decline in testosterone. There is research that shows that DDE a metabolite of DDT acts as anti-androgen. This means that one will feel and act less like a man when exposed to it, ranging from a lack of libido to being a straight up wimp. DDT has also been linked to causing increased risks of diabetes and also provoking a lack of function within the thyroid hormones. They have also linked DDT to testicular cancer, which is more proof for how destructive this xenoestrogen is to the endocrine system. DDT is also linked to breast cancer but that is pretty obvious since it is a XENOESTROGEN.
As you can see Xenoestrogens range from sunscreen lotion to women's cosmetics, this lets you know that our endocrine system is threatened everyday just by our environment alone.
My friends the odds are stacked against us, and it does not end here.
Phytoestrogens
Phytoestrogens also known as "dietary estrogens", are a varied group of naturally occurring non-steroidal plant compounds that share of their similar structure with estradiol, and have the ability to cause estrogenic much more often than anti-estrogenic effects. Phytoestrogens primarily belong to a large group of substituted polyphenolic compounds; which comprise of the coumestans, prenylated flavonoids (the hobs you find in beer) and isoflavones (soybean are genistein and daidzein which are all bad for the endocrine system) are three of the most active in estrogenic effects in this class. The most researched and documented are the isoflavones, which are normally found in soy and red clover. Lignans have also been identified as phytoestrogens, although they are not flavonoids. Mycoestrogens have comparable structures and effects, but are not related to plants; they are mold metabolites of Fusarium. Phytoestrogens exert their effects mostly through binding to estrogen receptors (ER). There are two variants of the estrogen receptor, alpha (ER-***945
and beta (ER-***946 and numerous phytoestrogens display fairly higher affinity for ER-***946; compared to ER-***945;. Besides the interaction with estrogen receptors, phytoestrogens can also modulate the concentration of endogenous estrogen hormones by binding or ceasing efficiency of some enzymes, and this could affect the bioavailability of sex hormones by binding or stimulating the synthesis of sex hormone binding globuline. Foods with the highest relative phytoestrogen content were nuts and oilseeds, followed by soy products, cereals and breads, legumes, meat products, and other processed foods that may contain soy, vegetables, fruits, alcoholic, and nonalcoholic beverages. Flax seed and other oilseeds contained the highest total phytoestrogen content, followed by soybeans and tofu. The highest concentrations of isoflavones are found in soybeans and soybean products followed by legumes, whereas lignans are the primary source of phytoestrogens found in nuts and oilseeds (e.g. flax) and also found in cereals, legumes, fruits and vegetables.Phytoestrogen concentration varies in diverse foods, and can contrast significantly within the same group of foods depending on processing mechanisms and the type of soybean extract used. Legumes, whole grain cereals, and several seeds are high in phytoestrogens. A more broad list of foods known to have phytoestrogens includes: soybeans, tofu, soy beverages, flax, sesame seeds, barley, dried beans, lentils, apples, carrots, pomegranates, wheatberries, oats, wheat germ, rice bran, soy linseed bread, ginseng, hops bourbon, beer, fennel yams, rice, alfalfa, mung beans and anise.
There has been an increase in reports about incidences of male reproductive abnormalities and falling sperm counts have driven interest into the nature of these threats to worldwide fertility. Xenoestrogens have been flagged as major culprits. These non-steroidal estrogens/oestrogens of plant derivation are potent endocrine disruptors that modulate normal physiological functions. Phytoestrogens have also become a major factor in the usual Western fast food diet over the last few decades. Soy formula milk is another widespread source of phytoestrogens, now used increasingly as an alternative to breast or cow's milk for infants with allergies. This use is of a HUGE concern since the most vulnerable periods for oestrogenic abuse are thought to be the pre- and neonatal periods when almost irreversible harm can be brought onto the developing child. Studies concerning the safety of phytoestrogens are now needed either to relieve fears or increase awareness of the effects of our current diet on potential fertility. (2005, Vol. 8, No. 3 , Pages 197-207 (doi:10.1080/14647270500030266)).
Phytoestrogens don't even provide benefit in women
A HEALTHY women post menopausal consumes less than 1mg of phytoestrogens, which is pretty much nothing. There was a study conducted with 964 postmenopausal Caucasian women who participated in the Framingham Offspring Study and completed the Willett food-frequency questionnaire (FFQ). By searching the agricultural and medical literature, they were able to identify food sources of phytoestrogens. The concentrations of the diverse isoflavones, coumestrol and lignans in each food in the FFQ were scored in seven categories, then multiplied by the serving size of the food, and the frequency of its expenditure. The estimated daily median intake of the isoflavone daidzein was 39 microg (24-57 microg); of genistein, 70 microg (28-120 microg); of formononetin, 31 microg (13-44 microg); and of biochanin A, 6 microg (2-11 microg). Median total intake of isoflavones was 154 microg (99-235 microg). The main sources of isoflavones were peas and soy beans. The estimated daily intake of coumestans was 0.6 microg (0.2-1.7 microg), with broccoli as the key source. The estimated daily median intake of matairesinol was 19 microg (12-28 microg) and of secoisolariciresinol 560 microg (399-778 microg). The median total intake of lignans was 578 microg (416-796 microg). The main source of the lignans was fruits. (J Nutr. 2001 Jun;131(6):1826-32.)
As you see from the information above, one serving alone of these phytoestrogens can be detrimental to women's health over a period of time. Even more so to a man!
Phytoestrogens have also been linked to immunosuppressive effects along a decrease in thyroid output function. These studies that linked phytoestrogens to immunodeficiency showed how consumption of SOY isoflavone and genistein lowered t-cells which we know is something that occurs usually in HIV/AIDS patients. HIV/AIDS is a diease which causes one's immune system to shut down completely allowing one to catch any disease.
Estrogen is all around us; it is well known that the estradiol level in 55-year old men, for example, is usually a bit higher than that of a 55-year old woman. Unfortunately after the age of the 30, men's testosterone levels continue to plummet 10 percent every 10 years. Many factors lead to estrogen dominance ranging from life stress to the xenoestrogens we consume. A man, however, does not develop breasts because he has a higher testosterone level than women do and a lower estrogen ( the world is changing this).
As men age, their estradiol levels gradually rise, whereas their progesterone and testosterone levels gradually fall. The hormone balance changes. These gradual changes lead to reduction in testosterone benefits and eventually to estrogen dominance.
That is, a mans estradiol effects emerge since his testosterone level is not sufficient to block or balance out the Estrogen. The Estrogen Dominance then stimulates breast cell and prostate hypertrophy. Estrogen Dominance is responsible for the majority of breast cancers and is the only known cause of endometrial cancer in women. Since the male prostate is pretty much the equivalent of the uterus, it should not be unexpected that estrogen dominance is also a major cause of prostate cancer as stated before.
In today's world estrogen dominance is accruing at a much younger age and at a much faster rate. Even for much younger when when estrogen is not completely dominant the much higher levels of estrogen is still causing life long problems.
Estrogen dominance is a growing health concern for Men all over the world. Although it is more common in older men. It is quickly becoming a epidemic in younger men causing such problems as infertility, erectile dysfunction, enlarged prostate, and certain types of cancer. Many of the symptoms can be seen in our youth today. Many of the symptoms you may even notice in your own life.
The symptoms of estrogen dominance in men include:
Low sex drive
Impotency/erectile dysfunction
Infertility
Male pattern baldness
Gynecomastia, or "man boobs"
Weight gain
Enlarged prostate
Prostate cancer
Testicular cancer
mood swings
and many many more.
Symptoms of the on set of gyno
puffy nips
Itchy and or sore nips
lactating or fluid from the nipples
Pain to the touch
Gynecomestia
In adolescent boys, the condition is often a source of distress, but for the large majority of boys whose pubescent gynecomastia is not caused by obesity, usually the breast enlargement shrinks or disappears within several years. The condition is usually caused by an imbalance of estrogenic to androgenic (usually estradiol to testosterone ratio) effects on the breast tissue, resulting in a surge of unconstrained estrogen action on breast tissue. Approximately only 4 to 10% cases of gynecomastia are due to drugs. The aromatization takes place in the cyto-chrome enzyme P-450. Both Digoxin and Furosemide are drugs reported to cause the gyno as well, however; anabolic androgenic steroids are the most common drugs in causing gynecomastia. Breast prominence can result from hypertrophy of the breast tissue, chest adipose tissue (fat) and skin, and is normally a combination of the two. Breast distinction due exclusively to too much adipose is often termed pseudogynecomastia aka psedogyno or sometimes lipomastia.
Types of Gynecomastia
Puffy Nips: is one of the more common forms of gynecomastia. This glandular tissue buildup is concentrated under and in general confined to the areola, however; it can be slightly extended outside the areola forming a dome shaped image to the areola.
Glandular: This form of gyno is common with bodybuilders as a result of the use of anabolic androgenic steroids. The undeniable overload testosterone levels from AAS (specifically any form of test) are converted to estrogen via aromatization. Bodybuilders and along other athletes are afflicted with gynecomastia in its purest form when suffering from AAS gyno. However; drug-induced gynecomastia can almost be resolves with the use of proper supplementation, if caught before permanent fibrosis develops and even after it can still be cured.
Gynecomastia in lean men is generally only a breast tissue gland with no added adipose tissue; heavier men will have sloppier looking gyno because of the adipose tissue covering the glandular tissue. Guaranteed treatment of pure gynecomastia can be done simply by removal of the breast tissue, which also rids of the gyno tissue. Most of the time the glandular tissue is benign but at times it can become malignant, so gyno is NO laughing matter and must be taken serious especially during or after a cycle. So good bro's make sure you keep an eye out on your chest during cycle and take good care of yourself during and post cycle. Again I must stress that any and almost all gyno can be treated with out surgery but in some cases it is better to take care of it sooner rather then later.
Adolescent/Pubertal Gynecomastia: The Congenital or Hereditary Gynecomastia is on average evident by the ages of 9 to 18 in young males. About thirty percent to sixty percent of young adolescent boys experience pubertal gynecomastia. UNFORTUNATELY, thirty percent possibly will live with enlarged male breasts for the rest of their lives, but in other cases the gynecomastia will go away with age. However, severe forms of adolescent gynecomastia may require an involvement, in conference with the patient, the parents, and child development professionals. Now of course there is hope for men who have lived with gyno all of there lives. Your parents may have neglected it but there is no reason you have to.
Adult or andropause gyno: This is the most common form of gynecomastia due to declining androgen levels with a rise in estrogen in elderly or post andropause men. Gynecomastia based off of post andropause in most adults is composed mainly of glandular tissue but it may contain varying amounts of adipose and tough tissue. Now you know why old men have those wrinkly chests that look like they never had the shape of pecs on them before.
Asymmetric/Unilateral: Unilateral gynecomastia occurs when only one breast is bigger due to a case of gynecomastia. The other breast is usually normal in size and shape. Bilateral Asymmetry occurs when gynecomastia is present in both breasts, of course; each being to a different degree. Most bodybuilders and boys during puberty acquire unilateral gyno, and by a pretty big margin I might add.
Severe gynecomastia: is described as an excess or loose skin, and severely enlarged breasts. This form of gyno is determined in part by age, reason being older people suffering from gynecomastia tend to have less skin elasticity and therefore will have a greater profusion of excess skin associated to gynecomastia. Experienced plastic surgeons will perform as much of the surgical treatment of severe gynecomastia as feasible through an aereolar incision so as to avoid widespread scarring. However, some scarring may be inevitable when treating severe cases of gynecomastia. The larger the gyno the more the scaring and this is why even if you are going to have surgery once should try to reduce gyno in size as much as possible beforehand
Pseudogynecomastia: is not composed of glandular tissue, but rather of adipose tissue (fat). It looks a lot like typical gynecomastia but requires different treatment. Exercise and diet can be very effective in preventing and fighting off pseudogynecomastia. Only if this regimen is unsuccessful should surgery be considered an option. This is generally the only type of gynecomastia which can be improved with liposuction, but removal may be used in some cases as well. This form of gyno is also known as "false Gynecomastia" and is often associated with obesity whereby insulin interacts with a surplus of sugars or certain carbohydrates, specifically those of which that have been processed.
Not just estrogen causes gyno!!
PROGESTERONE. IGF, GH, AND PROLACTIN INDUCED GYNECOMASTIA
Gynecomastia can be as a result of a number of agents including estrogens, progestins, GH, IGF-1, and prolactin may all be involved. Regarding prolactin, androgens decrease prolactin levels while estrogens increase prolactin. Non-aromatizing androgens such as DHT have by no means been shown to raise prolactin levels in humans, but testosterone has, due to its aromatization to estradiol. Prolactin secreting tumors also known as prolactinomas, are often linked with gyno. Of course in these cases the prolactin is believed to induce gyno by suppressing testosterone production. Prolactinomas that are adequately large to cause gynecomastia, do cause gyno as a consequence of the impairment of Gonadotropin secretion, which leads to secondary hypogonadism. Remember Prolactin only has a direct effect on breast tissue only when estrogen is present so they say ( how much is needed?). This is why they say lowering estrogen levels will lead to lower prolactin levels and then eventually less occupied progesterone receptors. Keep in mind just using something to lower estrogen will not cure gyno when progesteonr/prolactin is one of the culprits. Also take into consideration that as IGF and GH levels rise, they will also rise within the mammary glands which could cause a growth of glandular tissue if the rise in IGF and GH is too rapid. This in basic terms means you got the GYNO.
After awhile, excess levels of prolactin also lead to laction which is when the mammary gland secretes milk. I don't know about you my friend but milk coming from my nips just is not something I want to experience. And I have no plans to feed young children even my own. Secretion is not the only way of knowing your gyno is of progesterone/prolactin nature but it is one clear indicator.
Aromatizing AAS
There are AAS that are more likely to induce gynecomastia whether it be due to aromatization or aromatization with progesterone site binding. Here is a small/general list of the more common and moderate to high aromatizing compounds.
Any form of Testosterone
Dianabol
Deca Durabolin/nanodrolone (progesterone)
MethylTestosterone
Methyltrienolone
Any form of Trenbolone (progesterone)and androgenic
Anadrol 50 Receptor cross over
Nondrolone Laurate (progesterone)
Norethandrolone
M 1,4ad
13-ethyl-3-methoxy-gona-2,5(10)-dien-17-one (progesterone)
2a, 17a-dimethyl-etiocholan-3-one-17b-ol
13 ethyl 3 methoxy
4-ad
Many people have reported receiving gyno from Superdrol, people question those accusations since superdrol is a 5aReduced compound, however; Professor Filimanov the formulator of Need2Slin.
" Prolactin is normaly caused by progestins, but can also be caused by dht, how?
For example, it is currently understood that when testosterone enters the cell cytoplasm it is subsequently converted to the more "active" androgen, dihydrotestosterone, DHT, by reduction at the 5alpha position, this is normal. Dihydrotestosterone is then either bound to a cytoplasmic "receptor" protein Rc, or is further metabolized to either 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol ,DIOL. The binding of DHT to its cytoplasmic receptor protein results in translocation of the steroid-receptor complex into the nucleus where presumably the complex dissociates and DHT exerts its androgenic effects. The transport of DHT to the nucleus can also result from the conversion of testosterone to DHT by nuclear membrane-bound 5alpha-reductase. Prolactin augmentation of DHT effects is envisioned as resulting from interaction of prolactin with its receptor, which due to the large size of the prolactin molecule is probably located in or on the plasma membrane.
Because superdrol is androgenic, but lacks the ability to show affinity via 5ar, it circulates, and this causes the large amounts of androgens to look for a transporter, so that it can bind to the androgen receptor, so it uses prolactin which has a high affinity to cytoplasmic receptor protein, allowing the androgens, testosterone, to be carried and allowing them to convert to dht, only problem is prolactin hormone or luteotropic hormone is synthesised and secreted by sex binding lactotrope cells in the adenohypophysis (anterior pituitary gland, And this gland now produces more prolactin to help deal with the large amount of testosterone circulating that hasnt bound to the estrogen of androgen receptor, Part of the reason why superdol is so anabolic, So instead of binding to the androgen receptors in the scalp and the prostrate it converts to dht through this unique process, using prolactin to enter the cytoplasmic receptror protein, and allowing it to convert to dht and then bind to the androgen receptors in the muscle, causing its distinct hardening effects, it still can't bind to the scalp or prostrate via 5ar as the form of dht it has converted too doesnt allow for that affinity.
So more prolactin is produced to allow for the superdol to find a receptor ,this excess prolactin triggers a process that fills the breast with milk via a process called lactogenesis, in men however it causes a distinct enlargment of the mammary gland and can even cause a man to lactate.
If superdrol had better binding to the androgen receptor via 5AR then this problem would be prevented, the other thing is that prolactin production can remain elevated for months after a cycle has finished, and once the androgen has been removed, ( the cycle is over) the cytoplasmic receptor proteins have nothing to do other than to allow the prolactin to proceed with its hormonal action within the body, causing the male mammary gland to enlarge ready to produce milk... Hence the REBOUND GYNO, this is why proper post cycle therapy (pct) is needed for superdrol, and the use of something to prevent prolactin."
As you see Professor Filimanov reinstates the correlation between prolactin/progesterone and estrogen which could lead to gyno even with a compound such as Superdrol.
Receptor cross over can also occur. Hormones are keys and your receptors are like locks. What happens is a hormone is ether placed in the body (by an out side source) or it is produced with in the body. This hormone we will call a "key". The hormone then sets out to find a "lock" that it can fit into,turn, and sequentially open up the components inside. To go one step more and make it a little more simple I will explain it like this.
Imagine your receptors as little treasure chest. Inside is chest it a set of instructions. This set of instructions can be a number of things. It can be directions to another chest or a task that must now be carried out. With out something to open the chest the instructions can never be carried out or the next chest found and opened. Following me ?
Some hormones are more like "dummy keys" will call them. They will find a "lock" and set them self into the "Lock hole" but then that is it. They never turn the key and open up whats inside. so we see hormones often work like this
1. Key fits a lock. AKA a hormone found a lock and set its self into it. Pretty simple
2. Key was not a dummy key and when it set its self into the lock it turned and opened up the chest letting out the instructions inside that will now be carried out.
3 "master keys" We will call them. Or "Muti function keys"
A subject not much talked about on any of the steroid forums or even in many articles I have come across is the fact that. In respect to anabolic steroids (out side source of hormones) most of them have all been explained as just "lock" and "key" . However the truth is pro hormones,disginer steroids and steroids all have "Multi function" and some even "Master key" functions.
as you can see explained earlier.
By now I am sure you are confused but that is fine. The body is a extremely complex thing and everyone's body acts the same yet differently when it comes to hormones. This is why a lot of times you must work with some one to help find out what works for you. To help find out more about you and how your body works, as well as the basics of science and how all things "should" work.
This last part has thrown many for a loop. Leaving many wondering why the have gyno when they did everything right, and used all the right compounds. The sad truth is there is no Guarantee that you will not end up with a case of gyno.
However there is one Guarantee and that being that no matter what the odds are on your side that your gyno can be reversed with proper supplementation my friends. You just need to know how. Often it is best to work with some one who has experience and has worked with many others to prevent or reverse gyno of all kinds.
Believe me friends, I know it is NOT easy by any means to feel comfortable about your body when you have gyno whether it be from puberty or AAS usage. It can really make one depressed knowing that their chest is not masculine appealing to the people around them or themselves. I know people who LOW SELF ESTEEM for years because of their pubertal gyno. We as people struggle on a daily basis to fit in whether it be through appearance, social status, or self accomplishment. The people I witnessed getting rid of their gyno, achieved all those forms of greatness and more at least to themselves which is all that matters; since it's your body and your life.
Now Of course it is time for the good part. The part every one has been waiting for. If all gyno can be cured then how?
Well My friends I am sorry to be the one to tell you. Yes there are drugs and products out there that work to reduce estrogen. Yes there are drugs that reduce progesterone and or porlactin. Yes there are serms that block the progesterone receptors. Yes all of these drugs and or supplements can be used to reduce,prevent, and even cure existing gyno.
However anyone out there giving you a cookie cutter gyno removing program is simple trying to do one thing. SELL YOU A PRODUCT/GROUP OF PRODUCTS AND OR DRUGS. Or they are only speaking from experience for what worked for them NOT YOU!!!
How many of you have used a friends advice because it worked for them,only to be disappointed when it does not work for you?
How many of us have tried everything only to find nothing worked? Or have you tried everything?
The fact of the matter is I do not hand out cookie cutter programs because although they may work for some they do not work for everyone. Each person must find out what works for them. Each person must learn how they will react to different products,drugs, and combination thereof.
One person my use nolva and it worked great for them. Another may use it and there gyno gets worse or they have a rebound long after. You must learn to read your body, learn what it is telling you. You must learn how to change things exactly when they need to be changed for you and why.
You must start off by having everything you need before hand. This is the one thing that is the same for everyone. When people make the statement "aaah just get some letro" Or hey man all you need is some arimadex and dostinex you will be fine" These people hardly know what they are talking about most of the time. They know what worked for them, they know what might have worked for others. However the most importent fact they know nothing about is WHAT WORKS FOR YOU AND HOW YOU WILL REACT.
Everyone is always looking for the cheap way out. Or the easy way out. SO often we jump all over the quick easy and cheap advice that is so readily handed out on the aas forums today.
When you are ready to do it right, when you want results, when you are at the end of your rope. Then you will bite the bullet and spend the money to get "everything" you need. A gyno removing program can have side effects and the proper supplements should be taken to counteract them.
When it comes to some causes of gyno you have to understand that it took years of exposure to out side estrogen to cause the problem. It may not be resolved overnight but it can be in the end and I am always here to help you do this.
Feel free to pm me any time my friends I am always here on the forums. :biggrin::biggrin::biggrin:
preventing Gyno of course is another topic in its self. When it comes to on cycle gyno prevention one should always use as little as he can or non at all if he can get away with it.
If you do not need it then do not use it. However always have it on hand IMO.
Many of the drugs known today for gyno prevention all have there pitfalls and some are better then others for different reasons. If prevention is what you are looking for then forma-stanzol happens to be the best choice for many different reasons. You can read more about this compound here in this thread. What is the overall best? Best steroid, best post cycle therapy (pct), best gyno treatment
5 to 10 pumps morning and night is all one would need depending on the dosing of the cycle you are on. Back up plans should always be in place and on hand. One should always have letro and dostinex on hand but never a need to use them unless nothing else works.
During post cycle therapy (pct) often people use just nolva or clomid and neglect that fact that these compounds do nothing to lower estrogen nor do they do anything at all for raised levels of prolactin or progesterone. Forma-stanzol on the other hand does.
BigKevKris
New member
I wasn't implying that you NEED clomid or nolva.....in my experience my most successful PCTs have had SERMs in them. I've run plenty OTC PCTs with great success as well.
mich29
New member
I agree
however imo by the time you start running cycles you should know what you need and what you don't need. some guys can run otc pct and be fine while others have to throw in serms
Similar threads
